1.1 ? "0 ???" ?? ???? ??? ???? ???????

???? ???? ??? GB 28050-2011 ???? ?100 ??? ≤0.5 ??? ???? ??? ??? ??? "???? ??" ??? ??? ?????

????? ????- “???? ??” ??? ??? ????? ?????? ??? ???? ??? ?? ????? ???

????? ???? ?? ??????? "??? ????? ???" ???? ???????? ???? ???? ?? ???? ???? ?????

1.2 ?????? ????? ????

????? ???? (C12H19Cl3O8) ???? ??? ??? ???? ?????? ????? ???? ???? ?????-

??? ????? ????? ?????? (???? ?????? ???????)

??? ???? ????? ???

????? ??? ??? (GI) 0 ???

???? ???? ???? ???? ?? ????? ?????? ?? ??? ???? ?????? ????

2.1 ??? ??????? ??? ????

?????? ????? ??? ????? ???? ?????? ???? ?????? ???? ????? ??? (1976)?

?? ???? ??? ????? ???- ????????? ????? ????? ????? (SO2Cl2) ?????? ?????

????????? ????? ?????/??? ???? ????? ???? 99.9% ????? ??????

???? ?????? ??????- ???? ?2024 ???? ??? 237 ????? ??????? ???? ????

2.2 ???? ????????? ??? ?????

???? ?????? ?????? "?????-???? ??? ??"

????? ? sucrose isomerase ?? ????? ????

????? ?????? ? 40% ????.

???? ?? ??? ?????? ??? ?65 ??? ?????

(????? ??? ??? ????? ???? ????? ?? ????? ??? ???? ??? ??)

???? ???? ???? ???? ????? ????? ????? ?? ????? ????????

3.1 ??-???? ????? ?? ????? ??? ????

?2024 ????? ???? ?????? 120 "????-??" ???? ?????-

17% ???-?? ???? ?????? erythritol ?? ??? ???? ????

8% ?????? ?????? ?? ?????? ????? ????? ????

3.2 ????? ???? ????

??? ??? ?? ???? ??? ???? ???? (N=5000) ?????-

62% ???? "0 ??? = ??? ???? ??" ??? ?????

38% ????? sucralose ??? ??? ?? ?? ?????? ???????

? ADI ???? ?? ???? ????? 9% ?? ????

???? ???? ????? ?????? ?? ????? ?????? ??? ?? ???

4.1 ?????? ???? ??? ??? ????

???? ????? ?????? ???? ??? ???? ?? ? 2024 ???? ???????

ADI ???? ?? ??? ???? ?? ???? ?????? ???? β ???? ???? ?????

??? ?? ?????? ???? ?? ??? ???? ?????? ??? (p> 0.05)

4.2 ?????? ?????? ?????? ????

????? ???? ???? ??? ????? ?????? ????? ??????? ?????? ????? ? ??? ???????-

???? ?????? ??? ? 10 ???? ??? (1 ???) ??? ????? ???? ??????

????? ?? ???? ?? ??? ????? ??? ???? ???? ?????

????? ??? ??? ????? ????? ?????? ???? ?? ???? ???? ??????

???? ???? ????? ???????? ?????-???? ???? ????

5.1 ???????? ????? ????

?????? ?????? Pichia pastoris ????? "??? ???? Brazzein" ????

??? ?????? ?? 1.8 ??? ???? (?2023 15 ??)?

5.2 ??????? ??? ???????

????? ???? ?? ??????? ????????? ?????? ???? ??? ????? ????? ????

???? ???? ?? ???? "???? ??????? ????? ???" ????? ???