1.1 ??? ??? ??? ??? ????????? ????

????? ?1956 ???? Takeda Pharmaceutical ????? ????? ???????? ??? ??? ????? ???? ??? ???? ???? ?????

• 1980???-????? ??? ??? ???? ??? ??? ??? ?? ??? ?? ????

• 2010 ??:????? ?? ????? ???????? ??? (PET-CT ????? ??? ??? ??? 23 ??? ??? ?????)

• ?2024 ?.?.?????? ???? NIH ? "???????? ????" ??? ??? ?????? ??? ??? ?????.

1.2 ???? ??? ??? ????

????? ???? ??? ?????-

?2024 ???? ???? 4.7 ???? ??? ???? (CAGR 12.3%)

???? ??? ?? ???? ?????? ??? ??? ?????? ????? ???? ???? ??? ? 400% ?????

?????? ??????? ????????-

Vascular dementia (?MMSE ??? ?2.1 ??? ?????)

????? ????? ??? (GOS ??????? ??? ?1.5 ???? ????)

???? ???? ????? ????? ??? ??? ?????

?

2.1 ????? ???? ?????

???? ??? ???? ???? ?????????? ??? ?????? ??? ???????? ??????? ??? 1? ???????? ????? ???? ?????? ????? ????? ??? II? ?????? ????? ????? ??? ????????? ?????? ????? (????? ? 18%) ??? IIB

?

2.2 ????? ???? ???? ??

? Sun Yat-sen ?????? ?????? ???? ????? ?2024 ????? ??? ?????????-

????? ??????? ????? ??? ? 6 ???? ??? 1000 ?? ??? ??? ??? ???? ????? ????? ????? ??? 7.2 ?.? ????.3

??? ?? ?????? ?72 ???? (p=0.34) ???? ???????? ??? ???? ???????

???? ???? ????? ????

?

3.1 ?? ??????? ??????

??? NICE ??????? ??? ?????? ??? ??? ???? ????? ?? ?????? ????? (??-?????? ?? ￡45,000/QALY)

???? ????? **2025 ??-????? ????? ??? ??? ????? ??? ??? ??? ??? ?? ???? ??? (p=0.21)

3.2 ???? ?????? ??? ????

????? ????? ???? ?????? ?2024 ???????-

12 ????????? ??????? ???? ("adjuvant therapy" ??? "????? ??? ?????" ??????)

????? ??-???? ???? ?? ????? ????? ? 32% ??? ??? ????? ????? ??? ?????? ??? 70% ??? ???? ????

???? ???? ?????? ???? ?????

?

4.1 ??? ?????? ????? ????

???-???? ????? ?? ????? ????? ????? (????? ?????? ??? ???? ??????? CN202410123456.7)

??? ?? ????? ??? ????? ???????? (???? ??? ??? ???? ???? ?????? ?????? ????? ????????? ???? ??? ??? ??????)

?

4.2 ?????? ????? ??

??? ??? ??? ?????????-

? CDP-cholinesterase ?? ??????? ??? (???? ??? 31% ?????) ?????? ???? ? 47% ????.

???? ???? ??????-??? ?????? ???

?

5.1 ???? ????

????? ????? ????? ??? ????? ????? ????? ???? ??? ?62 ??? ????? ????? ?? ???? ??????? ??? ?32% ?? 89% ??????

5.2 ????? ????? ??? ??? ????

"???? ??? ?????? ????? ?300 ??? ???? ?? ??? ???? ?? ????" - ????? ??? ????? ???? ? ??? ???? ???