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???? ???? ??? ?? ????? ?????? ??? ??? ?????? ?????? ?? ????? ??????? ?? ??????? ??? ???????? ????? ????? ????? ????? ??? ???? ?????????? ?? ?? ??? ?????? ?????? ?????? ??? ????? ????? ?? ???? ?????? ????? ??? ????? ??? ???? ????? ????? ??????
???? ??? ?? ??? ??? ???? ??? ???? ?????? ????? ??? ?? ??? ?? ???? ?????? ??? ?? ??? ??? ???????? ????? ???? ???, ?????? ?? ???? ?? ??, ????? ????? ??? ????? ???, ??? ????? ???? ????? ???? ???? ???-?? ?????? ?? ?? ???? ??????, ?? ??? ??? ??? ????? ?????? ?????????? ???? ???? ??.
?????? ?????? (SPD) ?????? ??? ????? ???-??????, ??-???? ?? ???? ??? ?? (cardiovascular and neurodegenerative) ????? ????? ??? ?????.
?.?.?. ???? 8 ?? 2024 ?????? ???? ?????? ???????? ???? ????? ???? ?? ???? ????? ?????? ??????? ??? ?? ???? ?? ??? ??? “????? ????” ????? ???? ?? “Spermidine ??? ?????? ??? ??? ??? ??? ????? ??” ??? ??? ??? ???? ???????
???? ???????? ?????? ???? ????? ??? ??? ??? ?? ??? ??? ???? ????? ???? ?? ????? ????? ??? ???? ????? ??? ?? ????? ??? ???? ???? ??????? ??? eIF5A-hypusination ???? ?? ??? ??? ??? ??? ??? ?? ?????? ??.
???? ????? ??? ???? ?? ?????? ??? ??? ??? ?????? ??? ???? ????? ?????? ?? ????? ???? ????? ????? ??? ??? ??????? ????? ?? ???? ????? ???????
????? ??? ??? ??? ???? ????? ????? ??? ????? ???? ?????? ??? ??? ???? ??????? ??? ???? ??? ??? ?? ????? ????? ???? ????? ???? ??? ??? ???? ???? ???? ????????? ??? ?? ???????? ???????????? ???? ?? ???? ????? ?? ????? ??? ????? ??? ???? ????? ????? ?????? ????? ?? ????? ??? ?? ??? ???-?? ????? ????? ????? ?? ??? ??? ?? ??? ??? ???? ??????, ????? ????? ?? ????? ???.
?????? ??????? ????? ??? ???? ?????? ????? ??? ?? ??? ?????? ??? ????? ?? ????? ????? ??????? ???? ??? ??? ????? ??? ??? ???? ????? ???? ??? ??? ?????? ?????? ??????? ??? ?????? ?????? ??? ???-??? ???? ??????? ???? ???? ? ?? ??? ?????? ?????? ???? ???? ?? ??? ????? ?? ?? ????? ???? ??????? ???? ?? ????? ???
?????? ????? ???? ??? ???? ???? ????? ???? ??? ???? ???? ???, ????? ????? ??? ???? ?????? ????? ?? ???? ???-???? ???? ????? ????.
???? ??? ????? ??? ?? ?????? ???? ?????? ??? ????? ?? ????? ?? ??????? ?????? ???-?? ??? ??? ?????? ??? ?????? ??? ???? ?? ??? ???? ??????? ??? ?????? ?? ???? ?? ?????? ?????? ????? ??? ??????? ?? ????? ??? ??? ????? ???? ?????
??? ???????? ??????? ??? ????? ????? ???? ????? ?? ???? ?? ????? ??? ??? ???? ??? ????? ??????? ??? ??? ?????? ??????? ?????? ????? ?????? ?????? ????? ????? ?? ??? ???? ?? ??? ??? ??? ??? ????? ???? ??????
?????? ????? ??? ?????? ???? ??? ??? ???? ?? ??? ???? ?? ??? ????? ????? ?? ??? ?? ???-??????? ?? ??????? ?????? ??? ??????.
??????? ?????? ??? ??? ??? ?? ? eukaryotic translation initiation factor eIF5A? ?????? ????? ?????? ?????? ??????-??????? ??? ????-????? ???-?? ???? ?? ????? ????? ???????? ????? ?????? ???? ???? ???
?????? ??? ?????????? ????? ????? ??? ??? ??? ??? ?? ??? ????? ??? ???? ???? ??????? ?? ?????? eIF5A-hypusination ???? ?? ??? ??? ??? ??? ??? ?? ?????? ??.