??????????? ???? ??? ???? ??? ?? ??? ? ????? ?????????? ??? ??? ?????????? ??? ????? ???? ???? ????? ???? ? ?? ?????? ???? ??? ??? ??? ?????? ?????? ?? ????? ???????? ???? ?????? ?????? ??? ??? ??? ?? ?????? ?? ???? ????? ?? ????? ????? ????? ???? ???? citicoline ???? ??, ?? ???????? ??????, ?????? (???? ????? ???? ????), ?????? ?? ??????

????? ? ribose, cytosine, pyrophosphate ?? choline ????? ??? ??????? ??. ?? ??? ??? ???? ??????? ??? ????? ??? ?? ??? ?????? ????? ??? ?????. ???? ??? ??? ????? phospholipid ???? ?? ???? ?????? ??????? ??????? ???-??? ????? ???-??? ???

Citicoline ???? ??? ???? ???? ????? ???? ???? ????? ??? ??, ???? ???? ????? ????? ??? ??????. ???? ?? ?????? ???? ??? ???? ??? ?? ???? ???? ????? ???? ?????? ??? ?????? ????? ??????? ??? radical scavengers ?? ??? ??? ???????? ??????? ?????? ???? citicoline ??? ??? ??????? ????

????????? ??? ???????? ?????? ???, ?? ???? ????? ???? ???? ????? ?? ???? ??? ?? ???? ??? ??? ????. ? citicoline ????? ?? ????? ?????? ???? ??? ???? ??? ???? ??? ?? ???? ??? ???? ????? ???? ????? ??? ????

????????? ????? ?? ?????? ????? ????? ?????? ??? ????? ????? ??? ???????? ??? ????? ????? ??? ??? ????? ?????? ?? ??? ?????? ???? ???? ??? ?? ???? ??? ?????? ?? ????? ??? ????? ???? ??? ???? ?? ?????? ????? ???? ??????? ????? ???? ????? ????? ???? ??? ????? ???? ??? ???? ????? ????? ????? ??? ???? ?? ??? ??????- ischemic and hemorrhagic stroke ????? ??? ischemic stroke ?? ????? ???? ??? ??? ?75% ??? 90% ?????? ????? ???? ??? ?????? ???? ?? ????? ??? ?35% -40.9% ??? ???? ???? ???? ???? ?? ?? ???? ???? ???????? ?????? ?? ?? ???? ??? ????? ???

????? ???? ????;

1. ?.?.?. ? 2002 ? ????? ???? ???? ???? ischemic ???? ????? ????? ?? ????? ????? ?????? ??-???? ???? ??? ??? ??? ????? citicoline ? 3 ?? ??? ????? ?????? ???? ???? ??????? ????? ?

2. ?.?.?. ? 2009 ???? ??? ??? ? 4191 ???? ischemic stroke ????? ?????? ???? ??? ??? ???? ??? ? ???? ???????? citicoline ? NIHSS ??? ?? ? BI ??? ?????? ???? ?? ???? ???? ???????? ????? ? ?? ???? ?? ?????? ??????? ???? ??? ? ?? ?????? ???? ?????? ??? ??? ?? ????? ??? ???? ??? ??? ??? (≧2000mg/??) ??? ????? ???? ??? ???? ?? ???? ?? ???? ????? ????? ?? ???? ??? [2]?

3. ??? ????? ?????? ?? ??? ???? ????? ???? ??????? ????? ??? ??? ????? ?? ???? ?? ????? ?????? ?? ???? ?????? ????? ??? [3] ???? ????? ????? ????? ???

4. ??? ???? ?????? ??? ????? ??? ????? ????-???? ????? ??? ?? ???? ???? ?????? ???? ???????? citicoline? ???? ?? ???? ????? ??? ????? ???? ???? ????? [4]?