?????? ????? ????? ?? ??? ????? "??? ?????" ?? "?? ??? ????? ???" ???? ????? ??? ??? ????? ??. ?? ??? ???? ?? ?????? ??? ?? ????? ?? ?????? ?????? ?????? ????? ??? ????? ???? ??? ????? ????? ????? ?? ???? ???? ??? ???? ??? “??? ????” ??? ???? ?? ?????? ??? ???? ??? ????? ??? ????? ?? ?????? ?????? ????

?

1. ?? ????? ???? ???? ???? ????? ?? ????? ????

????? ??? ????? ????? (??????? ???)?-

?

Membrane phospholipid ???? ??? ???????????? ??? ????????? ?? ???? ??? ??????? ???? ???? ??? ??? ??? Membrane phospholipid deradaration ?????? ?????/?????? ??? ???? ??? ???? ??? ???? ??? ?????????? ???? ???? ? phospholipid ??? ?????? ???? ? ?????? ???? ?? ??? ??? ?? ?????? ?????? ? ??? ???? ????? ????? ???? ???

???? ??? ???? ????? ????

?????????? ????? ???? ??? ????? ?? ? glutamate ???? ??????

????????? ?????- ??????? ??? ????? ?? ?? ????? ?????

? mitochondrial ????? ????-???? ??????? ???? ?? ???? ??????? ?????

???? ?????? ????? ??????: ????????, ????, ??? ?????? ????, ???? ??????? ?????.

???? ????? ????-???-?????? ??????? ???? ???????

??? ????? ???? ??? ?? ???? "????? ??? ???? ?? ?? ???" ?? ?? ??? ?????? ?????? .

???? ??? ??? ????? ?? ?????? ??????? ????? (?"???" ???? ???)?

???? ischemic stroke (?????)?

????? ??? (2012)? ??? ???? ??? ????? ??? ???? ????? ????? ?????? ??? ???? (?????? ??? ??? ????? ??? ????) ??? ????? ??????? ??? ????? ?? ?? ???? ??? ??? ?????? ??????

ECCO 2 ??? (2023): ??? RCT ???? ??? (3947 AIS ?????? ?????). ???? ???????? ??? ??? ??? ??? ?? (thrombolysis) ?? / ??? ????????? ????? ???? ????? ??? ?? (????? ? 24 ???? ???) phosphatidylcholine ? 14 ??? ??? ??? ??? ?? ????? ? 90 ?? ????? ???? (mRS 0-1) (43.5% vs 40.0%), ?? ????? ?? ???. ????? ????? ???? ?? ?????? ???? ??????? ??? ?????? .

???? ???-??????: ???? ????? ?? ???? ???? ??? ?????? ????? ??????? ?????, ????? ????? ?????? ????? (

???? ????? ??? (TBI)?

?COBRIT ???? ???? ????? ???? ??? ?? ???? ???? ???????? ????? ??? ???? (?????? ??? ??? ?????) ??? ?????

?????? ??? ???? ?? ??-?????- ???? ???? ???????? ????? ????? ?? ???? ????? ?? ???? ??? ????? ???????? ?????

???? ??? ??? ????? (????? ??);

Vascular cognitive impairment (VCI)/vascular dementia (VaD): ???? ???????? ????? (????, ?????, ????) ???? ????.

??????? ??? (AD)/??????? ??? (PD)?- ???? ???? ???? ???? ???????? ???? ????? ????? ???? ????? (?????) ?? ???? ??????? ??????

??? ???? ?? ?????? ??? ??? ?? ??? ???? ????? ????? ???? ????? ???? ???????

2. ?????? ??? ??? ???? ?"???" ?? "??"

??????? ?? ???? ?????? (? "????? ?? ????" ?? ???????)

?

???? ????? ??? ? '????' ??? ??. ????? ??? ??? (??? ????? ????)? ?????? ??? ??? ??? ????? ??? ?? ???? ??? ??????

?????????? ???? ?????? ??? ?? ?????? ??? ?? (???? ???? ???? ??? ??? 24 ???? ??? ????? ?????) ???? ????? ????? ?? ???? ????? ???? ????? ???? ??? ????? ??? ?? ??? ?????? ?????? ?? ? "?????? ??? ?????" ???? ????? ??? ???? ??.

? ECCO 2 ???? ??? ???? ??? ?? ?????? ??????? ????? ?? ?????? ??.

????? ????? ?? ?? (???? ???? ?? ????)

?

???? ischemic ???? ??? ???? ???? ??? ??? ???: ???? ???? ??????? recanalization (thrombolysis, thrombectomy) ??, ??? ?? ?????? ???? ???? ??? ???? recanalization (reperfusion ???, ??? ????? ??? ????, ???) ??? ??? ???? ????.

?????????? ???? ????? ?? (??? ???? ?????, ??-?????, ??-?????) ??????? ???? ?? ??? ?? ???? ????, ????? ???? ????? ?? ????? ????? ??? ????? ??? ??????.

? ECCO 2 ???? ???? ??? ?? ???? ????? ??? ? "????? ????????+" ????? ??? ??????, ???? ??? ???? ??? ???? ?????.

??????? ?????? ????? (????? ???? ?????)

?

??? ??? phosphatidylcholine ???? ?????? (

??? ??? ????? ??? ???? ??????? ???? ? ????? ???? ??? ????? ????? ????? ? ?? ???? ??? ?? ??? ???? ????? ?????? ???? ?????

?? "??" ????? ????? ???? ???? ??? ?? ??? ?? ???? ??? ?? ?????? ???? ??? ???? ????? ???

3. ???????/?????? ???? (?????? ?? ???? ????????)

????

???? "????? ?????? ?? ???? ????" ?? ??? ???? ???? ????? ???? ?????? ?

? ECCO 2 ????? ???? ?? ?????? ????? ?????? ??? ?????????? (???? ????? ??? ?? ??? ?? ???? ??? ?? ????) ???? ??? ??? ?? ????? ????? ??? ????? ??? ????? ? .

???????

?????? ???? ??? ? AHA / ASA ?????? ????? ???? ???????, ??? ?? ???? ????? ???? ?? ???? ????? ??? ???.

????? ????? ??? ?????? ?? ????????? (??? ???? ????? ??) ???? ????? ???? ?????

4. ?????? ????? ??? ???????

???? ???-??? ????: Neuroprotection ??? ?? ??? recanalization ??? ???? ????? ??? ???? ??? ??? ????? ??? ??.

????? ???? ????? ?????????? (??? ??) ?? ??? ????? ??? ???? ???? (??? thrombolysis/thrombectomy) ????? ???/???? ?????/TBI ?? ??? ????? ???????

???? ??????? ?????- ???? ?? ???? ??? ????????? ?????? ???? ????? ??? ?????? ????? ????? ???? ?? ????? ????? ???? ???? ???????? ?? ???? ???? ????? ??? ??????

????? ?? ????? ????? ???????- ???? ??? ????? ????? ????? ?????? ?? ?????? ???? ????? ??? ?????? ????? ????? ????

????? ?? Outlook

????????? ? "??? ?????" ?? "?? ??? ????? ???" ???? ????? ????? ??????, ?????? ?????? (???? ? ECCO 2 ????) ?? ????? ????? ???-???? ??? ??. ??? ?:

?

???? ????????- ?????? ?? ???? (???? ???/???-??? ?????? ???) ?? ?????? ???? ??? ???? ??? ????? ??? ?????

??? ?? ????: ??? ???? ????????? ???? ??? ???, ??? ?? ?????? ?? ?????? ???? ????? ??? ???? ??.

??? ?????? ??????- ??? ?? ????? ???? (????) ??? ????? ???? (TBI) ???? ?? ??? ????? ???? ????? ?? ???? ???? ??? ??????

?? ????????? ???????? ????? ???? ??? ????? ????? ischaemic stroke ???? ??? ??????????? ?? ????? ???? ?? ????? ????? ?"standard reperfusion therapy+core neuroprotection" ????? ????? ??? ?????? ??? ??? ?? ?? ???? ????? ?? ?????? ??? ?? ????? ???? ???? ??? ????? ???? ??? ??? ???? ?? ????? ??????? ?????? ??? ??? ???? ?????? ?????