1. ?????? ????? ?? ??? ??? ????? ???? ????

1. ?? ????? ?? ??? ?????? ??? ???
?????? ?????? ???? ????? ????? ??? ??? ?? ???? ??? ???? ??? ???? ??? ?????? ?????? ????? ??? ???????? 85% ????? ????? ??? ???? ?? ???? ???? ? ????? 15% ??? ???? ?? ???? ???? ???? ???? ???? ??? ???? ? ?? ???? ??? ??? 9mg/?? ????? ???? 28 ????? ??? ???? ?????? ??? ???? ???? ?? ???? ????? "?? ???" ??? ???????

2. ??? ???? ????? ??
?????? ????? ???? ???? ??? ???? ??? ????? (?????) ?2024 ????? ??? ???????? sucralose ???? ?? ???? ??? ???? ??? ??? ???? T1R2/T1R3 ??? ?????? ?? ?????? ??? ?????? ?????? 57.
????? ????? ?????? ? sucrose ????? sucralose ????? ???? ??? ? SGLT1 ???? ???? ???? ?? ??? ????? ?? ????? ???? ????? ?????? ????? ??? ?36 ????? ????? ???? 2 ???? ??? ????? 50 ??? ????? ??? ????? ?????? 30 ??? ??? ??? ?A1c (HbA1c) 5 ????? ?0.3% ??? ??? ??????
????, ?????? ?????? ????? ????

1. ???? ??? ????? ?????
?????? ????? ????? 600 ??? ?????, ?? ??? ??? ??? ?? ???? ???? ????. ?????-

30mg sucralose ?? 300ml ???-?? ??? ??? 10% sucrose ???? ?? ?????? ????? ???? ???? 16;
??????? 100 ??? ??? ????? ???? ??? 15mg ??? ????? ???? ?45g 48 ???? ??????

2. ?????? ???? ????? ???
????????? ?????? ?????- ???? ?????? ???? ????????? ????? ???? ??????? ????????? ??? ?50-80 ??? ????? ??? ?200-320 kcal ??? 27;
????? ?????? ????? ??? ??? ??? ?? ?? ?? ???? ??? ????? ??????? ??? ????? ????? ???? ?????? ?????? ?40% ??? ?????
????, ??? ?????? ?????? ???

1. ???? ??? ????? ?????
???? ???? ???? ?????? ??? ??? ????? ????? ???? ????? ?? ??-???? ????? ???? ??? ????? ??? ?? ??? ?????? ??? ?27 ??? ?????
???? ??? ?? (cardiovascular) ????? ?????? ????? ???? ??? ?????? ?????????? ??? ????? ?0.4???/?? ???? ?? ???? ????? ??????? (LDL) ??? ?12%?78 ?????

2. ??? ????? ?? ????
???? ???? ??? ?????: ? 120 ℃ ??? ??????? ??, sucralose ???? ???? ???????? ????? ???? ??? ??? ???????? ?? ???? ????? ????? 38;
?????? ???????- ?????? ???????? ?????? ??? metformin ?? ????? ?? ??? ???? ?????? ???????? ?? ?2 ??? ???? ??? ??? warfarin ?27 ?? ??-??? ???? ?????? ???? ?????
????, ??-???? ?? ????? ????

1. ????? ????? ???
???? ?????? ???? ??? ????? ?????? ???? 62% ????? ?? ?????? ??? (PHQ-9) ???? 3.2 ??? ??? 68. ?.?.?. ? 2024 ?????? ????? ??? ???????? ????? ???? ??? ???? ?????? ???? ??? ?????? ???? ? 43% ?? 79% 3 ?? ????

2. ????? ?? ?????
????? ??? ????? ???? ????? ???? ????? ?? ??? 3200 ???/?? 78 ????? ????? ???? ????? ??? ???? ?????
???? ?????? ????- ???? ?? ??? ???? ???? ????? ?18 ??? ?????? ?? ?2025 120 ???? ??? 14 ????? ??? ??????

5. ??????? ????? ?? ????? ?????

1. ?????? ????? ?????
?????? ??? ????? ???? ?? ???? ??????? ???? ??? 9mg/kg ???? ????? ???? (? 60kg ????? 540mg ???) ?28;
???? ???? ????? ???????? ????? ???? ????? ???? ?? ???? ???? ????? ???? ??? (?????????? ?????? ??? ??? ? 30% ?? 8%)?18.

2. ?????? ??? ????
???????? ?????? ??????- ???? ?????? ?2025 ?????? "???? ???? ??????" ??? ???? ????????? ??? ?? 0.01 ?????8 ??????
????? ?? ?????? ????? ???? ??? ??? ???? ??? ???? ?????? ???? ?? ???? ????? ???? ?? ?????? ?100,000 ??? ???? ??? ????
??????
????? ???? ?????? ???? ?????? ??? ???? ?? ???????? ???? ???? ? ??? ?? ???? ?????? inertia ? ??? ??? ??? ????? ????? ?? ????? ????? ??? ????? ???? ????? ?????? ???? (??? ???? ???????? ?????) ?? ????? ????? ????? (???? ? 2025 ???? ?????? ??? ??? ??????? ????) ? sucralose ???? ??? ????? ???? ????? ????? ?? ???? ???? ???? ????? ??? ??? ???? ??? ?????? ????? ?? ???? ??? ?????? ????? ?? ?? ??? ??????? ?? ????? ????? ????? ????? ???? ?? ?????? ??? ????.