?????? ??? ??? ??? ????? ??? ??? ?????? ????? ?? ?????? ?? ???? ??, ?????? ????? ????? ??????? (??? ???? ?? ?????? ?????), ??? ??? ?????? ???? ??? ?????? ????? ??? ??? ?? ????. ????? ???? ????? ???? ???, ??? ?? ???? ????? ???? ?????? ??????. ???? ?????? ???? ?????

?

1. ????/???? ??????? ????

????? ???? ?? ?????? (rUTI) ????? ?

??????- ???? ??? ????? ?????? ???? ??? ???? ????? ???? ??? ?? ??? ????? ??? ????? ??? ?? ??? ??? ?????? ?? ?? ?????? ??? ??????? ???????? ?????? ???????? ??? ??? ??? ?????? ?? ???? ?????? ???????

?????-

??? ???????? ??????? ????? ???? ????? ???? ???????? ??? 1.5-2? ???? ???? ?? ? Escherichia ??? ????? ??????? RUTI ?????? ????? ??? ??? ????????? ??? ???? ?? ?????? ??? ????? ???

????? ????? ???? (EAU) ?????? ? RUTI ????? (????? ???: B) ??? ???? ??????.

??? ????: ???? ????? (??? ????? ???? ????? ????), ??-?????? ??????? ????? ??? ????.

????: ?????? ?? ?????? ?? ???? ??????? ??????? ?? ????????? ???? ?????; Escherichia coli ???? UTI ?? ??? ???? ????? ???

2. ????? ??? ?? ?? ???? ?? ??? ??? ????

???? ?????? ?????? (CDG) ????

?

??????- ????? ???? ??? ?????? ???? MPI-CDG (CDG-Ib ????)? phosphomannose isomerase (PMI) ???????? ??? ????-6-???? ?? ?????-6-???? ??????? ??????? ??? ?? ?? ???? ???? ???? ?????

????? ? mannose ??? ??? ?????? ? PMI ?????? ???? ???? ????-6-???? ????? ??? ? glycoprotein ????? ??????? ??????

??? ??? ????-

???? ??????-??? ???? ????? ?????? ??? ???? ???? ???? ???? ??? ????? ??? ???

???? ??? ?? ??? ??? ????, ??? ???? ??? ?? ????? ???? ?????, ??? ?? ???? ?? ????? ??????.

????- ??? ALG-CDG ?? ??? ???? ??? ????? ???? ???? ??? ????

???-??? ??? ????? ???? ?? ?????? ????? ???? (?? ??? ????? ????)

?

??????-

???? ?? ?????????- Tumor related macrophages (TAMs) ????? ??? ????? ??? ??? ???? (MRC1) ?? ???? ????? ?????? ???? ???? ?? ???? ???? ?????

?????? ??? ?????? ???? ??????- ???? ????? ?? ???? ????? ???? ??????? ???????? ?????????? ??? ?? ???? ???? ??????? ??????? ?????? ?????? ???? ?????? ????? ?????

?????? ???? ?????- ?????? ???? ??? ????? ?? ????? (??? ??????? ??) ???? ??? ????? ???? ??? ???? (?????? ????? ?????? ??? ??? ?????)?

?????? ???? ??????? ??? ??? ?? ?????? ????? ?? ???? ???? ???????

??-????/???????? ?????? ??? ???? ??

?

??????- ??? ???? ?????? ?? ??????? ?? ??? ??? ?????? ???? ????? ??????? mannose ???? ?? ??????? ???? ??????? ???? ?????

?????-

????? ?? ?????? ???? ??? ???? Candida ? epithelial ???? ?? ????? ??? ?????

???-?? ?????? ?? ???? ???? ??? ??? ?????? (?????? ?????) ??????? ??? ?????.

????- ???? ??-?????? ??????? ?????? ????? ?? ?????? ????? ????? ??? ????

3. ?? ?? ???? ?????? (????? ????)

???? ????? ??? (IBD) ?? ????? ????? ??

?

????

???? ????? ????????? ?????? (??? ???????? ??????) ?? ??? ??? ?????? ????? ???????

? glycosylation ???? ?????? ????? mucosal barrier ?????? ???? ?????

???? ???: ?????? ???? (colitis) ????? ?????? ????? ????, ??? ?? ???? ???? ?????.

??? ?????? ?????? ????? ??

?

???-???: ?????? ?????????? ?????? ???????, ??? ?? ??? ????? ?????? ??? ?????. Mannose ??? ? glycosylation ?????? ??????? ????.

????? ?? ??? ????? ????? ???? ???? ??? ??? ??? ??? ???? ?? ?? ???????

???? ??? ????? ?????

?

?????? ???? ??? ??? ???? ??? ??????? ???? ?????? (AGEs) ?????? ??????? ??? ???????? ??????? ???? ?????? ?????? ?? ?????? ????? ?? ??? ??? ??? ????? ??? ?? ???? ?????, ??? ???????? ???? ????? ?????.

????: ?????? ????? ???????? ???? ??? ????? ???? ????? ??, ?? ???? ???? ?? ??.

4) ?????? ?? ????

??? ??? ?? ?? ?? ????

????? ????? Escherichia ??? ???? ?????? ?? ???? ?????; ???? ?? ?????? ??? ?? ????? (???? ????? ???? ????)

???? ???? ????? ??? ????? ?? ???? ??; ??? ???? ?? ???? ?? ????? ??????

??? ??? ??? ?? ???? ?????? ??????; ???? ??? ??? ???? ?????? ????; ?????? ????? ??????? ???? ????? ??????

???-?????? ??? ????? ??? ????? ?? ???? ??????; ???? ?????? ?? ????? ????? ????? ??????

???? ???? ???? ??? ?? ???? ?? ??? ????; ???? ??? ???? ????? ????? ????; ?????? ?????? ??? ??? ??? ????

5, ????? ????? ????

????? ?????? ???? ????? ???/?????? ???? ???? ????? ???? ????? ??????? ???? ?????

????? ???? ??????- ????? ???? ????? ?????????????? ????? ????? ??????? ?? ??-???? ?????? ?? ????

???? ???? ?????? ???? ???? ??? ????? ?? ????? ???? ???? ???? ???? ?????

???? ?? ???? ????? ??? ?????? ?????- ?????? ??????? ??? ???? (??? ???? ????? ? UTI ?????)?

???? ??? ?????? ???? ??? ???? (UTI) ??? ??? ????? (???) ?? ?????? ????? ?????