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    2024-08-28

    ????? B3, ?????? ???? ????? ?????, ????? ??? ????? ??? ?????? ?????? ??????? ??? ??? ???? ????? ??. ???? ???? ????? B3 ????? ???? ???? ??? ??? ?????, ??? ???? ????? ??????, ????? ????? ???-??? ??? ??? ???.

    ????? ???? ??? ???? ??? (NAFLD) ???? ??? ?? ???? ???? ??? ???? ????? ???? ?? ? ???? ??? ? 150 ???? ??? ????? ?? ? ?????? ??? 10-20% ????? ?? ????? ???? steatohepatitis (NASH) ???? ? ?????? ????? ?? ???? ?? ??? ????? ? ???? ?? ??????? ??????? NASH ????? ?????? ???? ?? ??? ????? ?? ???? ???? ?? ??? ???? ????? ???? ??? ???? ???

    ???? ? Sun Yat-sen ?????? ???? ?? ????? ?? ??????? "?????? ???? ??? ?? ???? ????? ?? ??? ????? ????. ??? ??? ???" ????? ???? ??? ??? JAMA Network Open ????? ???? ?? ??? ???? ??????.

    ??? ???????? ?????? B3 ???? ??? ???? ??? ????? ???? ??? ??? ??? ????? ????? ?? ??? ???? ???? ???? ??? ??? (≥26.7mg/??) ??????? ?? ???? ??? ??? (≥26.7mg/??) ??????? ?? ????? ??? ???? ? 30% ???? ?? ???? ??? (≤18.4mg / ??)?

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    ??? ??? ??????? ?????? ????? B3 ????? ???? ???? ????? ?? ????? ?? ??? ??? ??? ??? ????? ????? ?????? ????? B3 ???? ????? ??? ?? ?????? ??? ??? ??? (NHANES) 4,315 NAFLD ????? ???? ??? 53 ??? ?????? ??? ??? ?? ???? ????? ???????

    ?????? B3 ????? ?? ?????? ?????? ???? ??? ??????: ???? ???? ??? (≤18.4mg / ??), ????? ??? ??? (18.5-26.6mg / ??) ?? ???? ??? ??? (≥26.7mg / ??).
    ? 8.8 ???? ???? ????? ?? ??? ?????? 566 ?? ??????, ????? ??? 197 ? ??? ?? ??? ?? (cardiovascular) ????? ????? ????? ???.

    ????? ?????????? ???? ??? ???? ?????? ????? ???? ??? ???? ?????? ?? ????? ???? ?????? ?? ? 30 ??? ??? ???

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    ??????, ???? ??? ???? ?????? ???? ??? ?? (cardiovascular) ?? ???? ? 35 ??? ?????, ??? ?? ?? ???????? ??? ?????.

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    ???? ???? ?????? B3 ????? ?? ???? ??? ?? ???? ?????? ?? ???? ???? ??? ?????? ?????, ??? ???? ??? ????? ????? ?? ????? ????? ??? ?????.

    ??? ??????? ??? ???? ????? ??? ????? ??? ??? ???? ???? ?????? ?? ???? ????? ??? ??? ? ???? ??????? ???? ???? ??? ???? ????? ?? ???? ?? ???? ??????? ????? ????-????? ???? ??? ???? ???? ??????? ?? ????? ???? ?? ????? ?? ??????? ?????? ?????? ???? ?????? ?????? ????? ?????, ????????? ?????????? 2 ?? NADPH oxidase ??????? ?? ??? ??? ???? ????? ?????? ???? ???.

    ??????? 2023 ? Sun Yat-sen ?????? ???? ?? ????? ?? ??????? ???????? ???? ?? "?????? ???? ??? ?? ?????-????? ??? ??? ??? ???? ??? ????: NHANES 2003-2018" ????? ???? ??? ??? ??? ???? ???????

    ??? ???????? ?????? B3 ???? ??? ????? ???? ??? ??? ??? ????? ????? ???? ??? ???? ????? ??? ???? (≥29.2mg/??) ????? ???? ??? ??? ??? ???????? ????? ????? ??? (≤16.3mg/??) ?? ????? 31% ??? ???

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    ???? ???? ????? ? 3 ???? ??? ????? ?? ??? ???? ????? ????? ????? ???? ????? ??? ????-??? ??? ???? ??? ????? ????? ??? ??? ?? ????? ????? ?????? NAFLD ????? ????? ??? ??? ??? ???? ????? ??????? ?????? B3 ??? ?????? ???? ???? ??????.