?.?.?. ?1930?? ????? ?? ??????? ???? ???? ???? ??? ???? ???? ???? ??? ?? ??? UV irradied ???? ????????? ?????? ???????? ????? ????? ???? ???? ????? ? ????????? ????? ??? ??? ??? ?? ??? ??? ????? ???? ??????

????? ? (???? ??) ??? ???? ????? ??? ??? ???-???? ???? ?? ????? ?????? ??? ?????? ?????? ??? ??? ??? ??? ???? ????? D3 (cholecalciferol, cholecalciferol) ?? ????? D2 (calciferol) ???. ?????? ??? ????? ????? ? ????? ?????? ?????? ??? ?? ?????????? ??????????? ????? ??? ???? ???? ??? ????? ????? ?? ?? ??? ?chylomicrons ??? ?????? ????? ???? ?? ????????? ????????? ?? 1,25-????????? ? 3 ?????? ??? ?????? ?????? ??? ?? ?????? ???? ???? (CaBP) ????? ???? ??? ??????? ?????? ????? ??????? ?? ?????? ????? ??????? ??? 7-dehydrocholesterol, ??? ??? ??? ??????? ??????, subcutaneous ????? ?? ???? ???? ??? ???????? ??? ?? cholecalciferol ?? ???? ????. ?????? ?? ????? ????? ??????? ???? ????? ? ??.

?? ?????? ??? ??? ??? ?? ????? ??, ??? ??? ????, ????? ??? ???, ???? ???? ??? ????, ??????????, ??? ?? ?????? ?????? ?? ??? ??? ????? ??? ????. ?????? ???? ??? ??? ??? ?? ?????? ???? ???? ????? ??? ???? ????? ????? ?????? ???? ??? ?? ???? ???? ???? ???? ???? 400 IU (??? ??? ????) ??? ????? ??, ????? ? osteomalacia ????? ???, ?? ??? ????? ????? ???. ??? ??? ??? ????? ???? ??? ?? ???? ?????, ??????, ??? ??? ????, ????? ????? ???? ?? ????? ???. ?????? ? ???? ??? ???? ??? ??? ??? ?????? ??? ????, ???? ???? ???, ?????, ???? ?? ???? ???? ectopic ossification ?????? ????.