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    VK3 ?????? ???? ???? ??? ??????

    2024-11-03

    ????? ?? ?????? ??? ????? ?????? ??? ???? ?????? ???? (??) ?? ??? ???? ??? ??? ????? ????? ?? ??? ???? ?? ?? ????? ????? ??????? ??? ?????? ????? ??? ??? ???? ???? ????? ??? ??? ?????? ???? ???? ???? ????? ??? ????? ??? ?? ????? ????? ??? ??? ???? ??????

    ??? ??, ????? ?????? "?????? ??? ????, ??? ???? ????" ?? ??, ?? "???" ?????? ?? ???? ???? ??????. ?????? ???? ???? ?? ???? ??? ??. ??? ?????? ????? ??? ?? ????? ?? ??? ???? ???? ???? ????? ?????? ??? ?? ???? ???? ??? ?????? ????? ???? ???? ??? ????? ?? ??????? ???? ????? ?????

    ????? 25? 2024? ?????? ??? ????? ??? ????? ????? ???? ????? ??? ????? ??? ??? ?????? ???? ???? ??? ???? ?????? ??-??????? ??? ?????? ? ??? ??? PI 3-kinase VPS34 ????? ????? ????? ?????

    ???? ???????? ??-?????? ??? ????? (????? K3) ?????? ????? ???? ????? ????? ????? ??? ??? ???? ?????? ? ??? ??? ??? ????? ????? ?????? ???? ?????? ??? ????? ?? ?????? ???? ????? ??? ????? ??????? ?? ????? ?????? ??? ???? ???

    ?????? ???? ???????? VPS34 ?phosphatidylinositol 3-kinase (PI3K) ??? ??? ??? ????? ? VPS34? ?????? ???? ? PI3P ???? ????? ?? ?????? ???? ???? ??? ????? ?????? ????? ?????? ????? ???? ???? ???? ???? ????? ???? ??? ????? ?????? ?? ???? ???? ????? ?????? ? ????? ??? ????? ???? X-linked myotubulin myopathy (XLMTM) ???? ??? ????? ?????? ?? ????? ??? ????? ??????

    ???? ???? ????? ??? ??? ????? ??? ?? ???? ????? ???? ?? ? kinase ?????? ????????? ????? ???? ??? ????? ????? ???? ??? ????? ?????

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    ??? ? RapidCaP ????? ????? ??? ?????? ???? ????? ???? ????? (?????)? ?????? ? ??? ???? ??? ???? ????? ????????? ?? ??? ???? ? MSB ??? ?????? ????? ???? ???? ?? ??? ??? ?????? ??? ??????? ????????

    ??????? ????? ????? ???? ?????? ????? ??-?????? ?????? ?????? ??? ???? ?????? ????? ???? ???? ???? ??? ???? ???????? ?????? ?? ????? ????? MSB ? PI3K kinase VPS34 ??????? ????? ? PI3P ???? ????? ?? ??????? ????? ?????? ?????? ???? ???? ?? ??????? ??????, ? X-linked myotubular myopathy (XLMTM) ???, MSB ? VPS34 ? kinase ??????? ??? ????, PI3P ????? ????? ??????? ????? ?????.