????? ??? ?? ?? ???? ???? ???? ?? ????? ???? ???? ????? ????? ??? ??? ???? ? ?? ? ????? ? ??? ??? (????? 1) . ???? ???? ? intermolecular disulfide ??? ??? ???????? ???? ???????? ????? ???? ??? ??? ?????? ???? ???? ???? ??? ?? ?????? ???? ??? ????? ??? ????? ???? ???? ??, ?? ????? ?? β - ???? ??????? ???, ? glutamine (Gln) ?? ??????? (??) ????? ??. ????? ???? ???? ?????? ???? ???? 35 ?.?? ?? ??? ???? ??? ??? ????? ?? ???? ??? ??? ?? ?70% ??? 80% ????? ???? ???? ????? ???? ??? ????? ?? ???? ?? ???? ???? ??? ?????? ???? ???? ???? ??? ??????? ?????? ??? ??? ???? ?? ?????? ?????? ???? ??????? ???? ???? ???? ??? ?????? ?????? ??????? ????? ???????? ???? ?? ? intramolecular disulfide ???? ????? ???? ???? ?? ??? ????? ???? ?????? ????? ??? ????? ???? ???? ???? ????? ?????????? ???????? ?? ?????? ???? ????? ???? ?????- ???? ??? ?? ?? ???? ??? ???? ???? ????? ???? ????? ???? ??? ????? ??? ????? ???? ????? ??? ??? ??? ?????

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