???? ???? (???) ?????? ??? ?? ???? ?????? ?????? ???? ??? ???? ????? ??? ????? ?????? ???? ????? ?? ???? ???? (???? ? ?????? ? ??? ? ???) ?? ???? ??? ???? ???? ??? ????, ??? ??? ???? ?????? ???? ?? ????? ?????? ???? ???? ????.

??? ?? ???? ?????? ???? ?????: inulin, glucan, ????? ?????, chitosan, oat β-glucan, ?? ??, ???? alginate, ???? ???????, ???. ???, ???, ???, ????, ???, ?? ?? ?? ??? ??? ?? ????? ???? ??? ??? ???? ???? ????? ???.

?????, ??-???? ?????? ????, ?????? ???? ?? ??? ????? ?? ???? ???? ?????, ???? ???? ??? ???? ??? ??? thickener, ?????? ???, ?????? ?????? ?? fillers, ??? ?? ??? ??? ???? ??? ?? ???? ???? ??? ??? ?? ????? ???, ??-??? ?????? ???? ???? ??? ???, ???? ????? ???? ??? ?? ???.

??? ??? ???? ?????? ???? ??????? ????? ?? ?????

??????, ???? ??? ?????? ?? ???? ????? ?? ????

??? ??? ???? ?????? ???? ????? ??? ?? ??????? ??? ?? ? ??? ???? ??? ??? ? ???? ??? ?????? ?? ???? ?????? ???? ?? ??????? ???? ?????? ????? ?? ???? ?????? ??? ?????? ???? ?????? ?????? ??? ??????? ?? ??? ?? ????? ??? ?? ?????? ?????? ????? ???? ??? ????? ????? ????? ????? ?????? ??? ????? ?????? ?? ????? ????? ???????

???? ???? ???? ??? ??? ???? ?? ????? ???? ???????? ?????? ?????, ???? ?? ????? ?????? ?? ???? ?????? ????? ??? ???? ??? ????? ?????? ?? ????? ????? ????.

????, ? adsorption ?? ????? ????? ?? ????

??? ??? ???? ?????? ???? ?? ?? ?? ??? ?? ? ??? ?????? ?? ?? ??? ?? ????? ??????? ???? ?? ??? ? ??????? ??? ????? ???? ? ??? ?????? ?? ???? ??? ?? ?????? ????? ?? ??? ??? ?? ???? ??? ???? ??????? ??? ????? ???? ??? ??? ???? ???? ?????? ?? ???? ??? ??? ?????? ?????? ???? ?

????, ????? ??????? ????? ???? ?? ??????

???? ?????? ???? ?? ???? ??? ? ??? ??? ?? ??? ????? ???? ???? ???? ??? ?? ??? ??????? ???? ???? ? ????? PH ? ????? ? ????? ??? ??? ???????? bifidobacterium ????? ?????? ? ????? mucous ??? ?????? ?????? ? ????? ?????? ??? ?? ?? ?????? ????? ?????? ????? ??? ????? ???? ??? ???? ???? ???? ?????? ???? ?????? ???? ??????? ????? ??? ????? ????? ?????? ?? ???? ??? ???? ???? ?? ?????? ?? ????? ????? ???????

4, ??? ???? ???? ???? ?? ???? ??? ???? ???? ?????

???? ?????? ???? ??? ?? ???? ??? ????? (???? ???? ??) ??? ????? ??? ????? ??????? ?? ????? ?? ???? ????? ??????? ?????? ?? ?????? ???? ????? ??? ?????? ????????? ?? ??? ??? ????? ????? ?? ????? ?? ???? ????? ? ?? ??? ???? ???? ????? ????? ????? ?????? ? ???? ?????? ???? ???? ??? ????? ?????? ??? ??? ??.

5.Solubility ?? viscosity ?? ????????

???? ???? ???? ????? ?? ???? viscosity ?? ??? ???? ???? ????? ???? viscosity ?? ???? ???? ?? ????? ??? ???? ???? ????? ?????, ???? ???? ???? ??????, ???? ??? ???? ????? ??? ??? ??? ??????, ???? ??? ?????? ???? ???????, ?? ??? ????? ?? ???? ????? ????. ???? ??? ??? ?????? ???? ???? ???? ?????? ??? ??? ???? ?????? ?? ?????? ????? ? ???? ????? ?????? ???? ??????

???? ??? ??? ??? ???? ?????? ???? ??????

?? ???? ?????? ???? ??? ??? ???? ?????? ???? ?? ???? ??? ? ?????? ??? ? ?????? ?????? ? ????? ? ??? ? ?????? ?????? ??? ? ???? ???? ?? ??? ????? ???? ??? ??? ?? ????? ????? ??? ???? ???? ??? ??? ??? ???? ?????? ???? ??? ?? ??? ???? ??? ?? ??? ??? ????, ???? ???? ?????, ???????? ??? ?? ???? ???? ??? ???? ?? ???? ??? ????. ??? ???? ????? ??? ??? ???? ?????? ???? ??? ???? ? ????? ? ???? ??? ?? ??? ????? ? ???? ??? ? ???? ?????? ? ???? ? ???? ?? ??? ???? ???? ?? ?????? ?????

?????? ??? ??? ??? ??? ??? ???? ?????? ???? ?????

1, ???? ?????? ?? ??? ???? ????? ???? ??? ?????????? ? ?? ? ????? ? ?? ?? ????????? ??????? ???? ???? ??? ????? ??? ?? ????? ????? ???? ??? ??? ??? ???? ?????? ???? ?????? ???? ???? ????? ????? ????????? ???? ??? ? mucous membrane ????? ?? ???? ??? ????? ????? ?? ????? ???? ?????? ??? ???? ??? ??? ??? ??? ?? ??? ???? ????, ??? ????? ???? ?? ?????, ?? ??? ??? ??? ???? ??? ????? ??????.

?????? ?? ??? ??? ???? ?????? ???? ?????? ??? ?????? ??? ???? ???? ???????? ?????? ???? ?? ????? ????? ??? ??? ??? ???? ? (9.84 ± 3.51) mmol/L ?? (6.82±2.65) mmol/L, ?? 2??? ????? ??? ??? ????? ??? ? (13.08± 5.12) mmol/L ?? 10.57± 4.61 all. ???: ?? ???? ?????? ???? softgel, fructan syrup, ??? ????? ????? ????.

2. ??? ???? ????? ??? ??? ??? ??? ??? ???? ?????? ???? ?????? ??? ???? ?????? ???? ???? ?? ??? ??? ??? ?????????? ???? ?????? ?? ?????? ????? ?????? ?????? ??? ??? ???? ?????? ???? ??????? ?? ??? ???? ??? bifidobacterium ?? Lactobacillus ?? ??? ???????? ?????? ?? ?? ??? ???? ??? ????? ???? ??? ???? ???? ???? ???? ??? ??? ?? ??? ??? ?? ????? ???? ????? ?? ??? ???????? ????? ????? ?????? ???? ????? ???? ????, ????? ???? ?? ??? ?????.

???? ?????? ??? ??? ??? ???? ?????? ???? ?????

1, ??? ???? ?????? ???? ???? ??? ??? ?????

??? ???? ?????? ???? ???? ??? ??? ????? ???? ???? ?? ????? ??? ???? ??? ?? ????? ?? ?????? ???? ??? ?????. ???? ???? ?? ????? ?? ?????? ???? ??? ???? ???? ??? ?? ?????, ?? ?????? ???? ??? ??. ??? ???? ?????? ???? ????? ???? ???? ????? ????? ???? ??? ???? ????? ?? ????? ??? ????? ????? ???? ??????? ??? ???? ???? ??? ??? ??? ???-???? ?????? ???? ???? 5% ~ 10% ?? ? ?? ????? ??? ???? ?????? ??????? ??? ??? ???? ?????? ???? ???? ?? ??? ???? ????? ????? ??? ?????? ??? ???? ???? ??? ????, ???? ???.

2, ?? ???? ?????? ???? ??? ??? ??? ?????

??? ????? ???? ?? ???? ???? ?????? ??? ??? ???? ???? ?????? ??? ??? ??? ??? ???? ???? ??? ??? ???? ???? ??? ????-???? ??? ???? ??? ???? ???. ????-???? ??? ???? ??? ??? ??: ????-??? ??? ??? 80%, ?? ??? ???? 3%, ???? fructose ??? ??? (71%) 3%, sucrose 2%, ?? 10%, ?? ???? ?????? ???? 6%, ?????? ??? 2.5%, stabilizer 0.2%.

3, ??? ???? ?????? ???? ???? ??? ??? ??? ????? ?? ??? ??? ???? ??? ???? ??? ?? ??? ??? ??? ???? ?? ?? ?????? ???? ??? ???? ??? ?? ????? ??? ????? ???? ???? ??? ??? ???? ??? ??? ????? ?????? ???? ?? ????? ??????? ???? ????? ????? ?? ??? ??? ???? ??? ??? ??? ???? ?????? ???? ????? ???? ???? ?? ???? ???? ????? ?????? ?? ??? ?????? ???? ??????

????? ???? (????? ??? ??? ??? ???? ??? ??? ????)?- ?? ??? (???? ???) 80% ~ 90% (9% ~ 12%)? ???? ?????? ???? ??? (71%) 6% ~ 8%? sucrose 4% ~ 6%? ?? ???? ?????? ???? 6% ~ 8%? ???? ??? 1% ? 2% ???? ??? ??? ???, ??? ???? ???. 4, ??? ??? ???? ?????? ???? ???? ??? ????? ???? ??? ?????? ????? ????? ???? ???? ???? ????? ?????? ?????? ?? ??? ??? ???? ???? ????? ???? ??? (???)? ?????? ???? ???? ???? ??? ?? ??? ???? ??????? ?? ??? ?????? ????? ??? ?????? ????? ?????? ????? ??? ????? ????? ?????? ????? ???? (???????) ??? ???? ???? ???. ??? ???? ?? ?????? ??? ????? ??? ??? ??? ???????? ????, ??? ?? ???? ???? ???? ??? ???? ??? ??????? ??? ???, ?? ?????? ?? ????? ???? ?????. ?? ???? ?????? ???? ?????? ?? ??? ???? ??? ??? ????? ???

???? ??? ????? ???? ?????? ?? ????? ????? ???? ???? ?????? ??????? ???? ??? ???? ???? ?? ??? ????? ??? ??? ??? ??? ???? ?????? ???? ????? ???? ??? ???? ????????? ??? ??? ????? ??? ??? ?? ???? ????? ??? ???? ????? ???? ???: ??? 30%, ???? ?????? ???? ??? (71%) 8%, sucrose 2%, ??? ??? ???? ?????? ???? 6%, pectin 0.4%, ??? (6%) 45%, ??? ??? 0.1%, ??? 0.1%, ?? 47.4%.

????, ??? ??? ???? ?????? ????? ???? ??? ????

?????? ???? ???? ????? ??? ??? ????? ???? ???? ???? ????? ?? ??? ?? ??? ??? ??????? ???? ???? ???? ????? ?????? ?? ????, ????? ??? ??? ???? ?????? ????, ??? ????, ???? ?? ??? ?? ??? ???? ??? ??? ??? ???. ????, ???? ?? ?? ???? ???? ??? ??? ????? ?????? ???? ??? ????? ?? ?????; ??????, ????-???? ????? ??? ?? ????-???? ?? ??? ????? ???? ???? ?? ????? ???? ??? ????? ??; ???? ??? ???? ??? ???? ???? ???? ???? ?? ?????? ????? ????? ???? ???? ???? ???? ??? ??? ??????

???? ?? ???? ????? ?? ??????? ??? ????? ??????? ??????? ???? ?????? ??? ???? ??????? ??? ??? ??? ??????? ????? ????? ????? ????? ????? ?? ??????? ???? ?????? ?? ???? ??? ???? ???? ???? ???? ??? ??? ?? ????? ????? ???????? ???.

1.??? ???? ?????? ???? ????? ???? ????? ???? ?? ????? ?? ????? ??? ????? ??????? ?? ????? ??? ????? ?????? ?????? ???? ?? ???? ????? ????? ???? ?????????? ?????? ??? ?? ?? ?? ????? ???? ????

?, ??? ??? ?? ???? ?????? ???? ????? ???, ??? ??? ??? ????? ???? ??? ???? ???? ????, ??? ????? ?? stratify ??? ?????.

????, ????? ??? ??? ?????

???? ???? ?? ????? ???? ?? ????? ?? ????? ??? ????? ??? ??? ???????? ????? ??? ?????, ???? ????? ???? ??????, ????? ????? ?? ?????? ??? ????? ?????. ??? ??? ???? ?????? ???? ????? ???? ???? ????? ?????? ????? ?? ??? ????? ? ??? ?? ??? ?? ?????? ??? ????? ?????? ??????

?????, ???? ??? ?????

?????, ????? ?????? ??? ?? ??? ???? ??? ?? ???? ??, ?? ??? ?? ??? ???? ???? ???? ??. ???? ???? ???? ???? ???? ???? ???? ??? ???? ??? ????? ????? ????? ????? ????? ?????? ?????? ???? ???? ?????? ????? ??? ??? ???? ?????? ???? ???? ??? ??? ??? ??? ??? ?? ??? ??? ? ???? ??? ??? ??? ??? ???

??? ???? ?????? ???? (Polydextrose) ????? ???? ????? ???? ???? ???? ??? ??? ?? ??? ???? ?? ???? ???? ???? ?? ????? ????? ??? ?? ??? ?????

??? ???? ??? ??? ??? ???? ?????? ???? ??????

??? ??? ???? ?????? ???? ??? ???? ?? ????? ?????? ???? ????? ?? ?????? ???? ????? ?? ??? ?? ???????? ???? ?????? ???? ?????? ???? ?? ???? ???? ??? ?????? ?????? ????? ??? ??? ???? ???

?????? ?????? ???? ?? ??? ????? ??? ???? ????? ?????? ?? ??? ????? ??? ???? ???? ????. ?????? ? ?????? ???? ???? ???? ? ???? ?????? ???? ? ???? ?? ? ???? ?? ?? ???? ???? ??? ??? ??? ??? ???? ???? ??? ?? ??? ??? ???

???? ???? ?????? ??? ???, ??? ??? ???? ?????? ????

1.?????? ???, ?????? ???? ??, ?? ?? ???

??? ???? ??? ??? ?? ???? ??? ???? ??? ???. ????? ?? ???? ??????? ???? ?? ???? ???? ????? ??? ????? ??? ????? ???? ???????? ????? ???? ?????? ???? ???? ??? ??? ?????? ?? ?????? ?????? ?????? ????? ?? ??? ?????? ???? ????, ????? ????? ??? ? 3% ??? 6% ??? ???? ??? ??. ?????? ???? ???? ????? ???? ??????, ?? ?????? ????? ?? ?? ??? ?? ?? ??? ???.

??? ???? ?? ??? ??? ?? ??? ??? ??? ????? ??? ?? ?? ???? ??? ?????? ?????? ???? ???? ????? ?? ??? ????. ???? ??? ??? ?????? ???? ????? ????? ???? ??? ? 3% ??? 6% ??? ??? ??? ????? ????? ????? ???? ????? ??, ?? ????? ??? ??? ???? ????? ??? ?????, ??? ?? ??? ????? ??? ????? ?????, ?? ????? ??? ??? ??? ?????? ?? ???? ?? ??? ???? ??. ??? ????? ????? ??? ????? ?? ????? ?????? ???? ?????? ??? ????? ???

????? ?? ??????? ??? 2.??????

???? ???? ???? ????? ?????? ??? ???? ?????? ??? ??? ?????? ?????? ????? ????? ??? ????? ?? ??, ???? ????? ???? ?? ?????? ????? ??? ???? ????? ?? ??. ??????? ???? ?? ?? ?? ????, ??? ???? ???? ?????? ?? ??????? ?? ???? ????. ??? ???? ?????? ???? ?? ?????? ??? ?????? ??? ???? ?? ???? ?????? ????????? ???? ?????? ?? ????? ??? ????? ?????

8.????? ???

???? ???? ???? ??? ???? ? ?????? ??? ??? ????? ??? ?? ??? ???? ??? ??? ??? ??? ??? ??? ????? ??? ?? ???? ??? ???? ??? ?? ????? ??? ????? ? ?? ???? ???? ????? ??? ??? ??? ??? ???? ???? ? ????? ???? ?? ?? ??????? ????? ??? ????? ?? ?????? ????? ??? ????, ??? ???? ??? ?????? ??? ????? ??? ????? ??? ?? ??? ????.

??? ? ????? ???

?????? ???? ???? ?? ??? ?????? ????. ????? ??? ?????? ????? ???? ??? 1% ??? ?????? ?????? ???? ?? ?3-5 ??? ???? ???? ?? ????? ???? ???? ??????

??? ? ??? ???? ???

?? ??? ??? ?? ??? ????, ????? ??? viscosity ????, ???? ????? ?????, ?????, ??? ??????? ???.