????? B12 ??????????? ???? ????

????

???? ?????

????

Hydroxycobalamin (ohcbl ??? B12a) ????? ?????? B12 ??? ??? ?????? B12 ???? ??? ??? ?????? ??? ????? ??? ??. ?? ?????? ?????? ??????? ????? B12? ???????????? ??? ?????? Hydroxycobalamin ??? ???? ??. ??? ??? ??? ??? ????? B12 ????? ???????????? ??? ?????? ??? ??, ???? ???, ??????????? ???? ?? ??? ????? B12 ? coenzyme ??? ?????. ?????? ???????????? ??? ?????? ???? ?? ?????? ????? ???? ??????? ??? ??? ?? (?????? ?????? ions ?? ??????)? ??????????? ???? ??? ????????? ??? ?? ????

????2

????

???? ?? ???? ???? ??? ??? ???? ????? B12 ??? ???? ???????????, ??????, ???????? ?? ????? ????? ???. ?? ????? ????? ? B12 ????? ??? ??? ????? ion ????? ????? ???? ???? ????? ??? ????? ? B12 ????? ion ????????? ??? ?? ????? ???? Hydroxycobalamin ??????????? ????. ???? ? 12 ?????? ???? ??????????? ???? ??? ??? ?? ??? ???? ?? ????? ?????? ??? ? ?? ??? ??? ?? ???? ????? ????? ?????? ??? ???? ????? ??? ????????? ?? ??????? ?? ????? ????? ???? ??? ??? ???? ??? ???? ?? ??? ???? ???? ???? ?????? ?? ?????? ???? ?????? ????, ????? ????? ????? amblyopia ?? ????? ???? ???? ???. ?????? ??????????? ????? ??? ?????? ?? ????? ???? ???? ???????? ??? ??? ?????? ??????? ??? ????? ????? ?????? ???? ????? ???

???? ????

????	?????	????
???? ?? ????? ????
???	??? ?? ?? ??? ??? hygroscopicity	?????
????	?361±1nm?550±2nm ?????? ????? ??? ?????	?????
????? ?? ???	≤12%	9.0%
???	09.0% -1.3%	1%
????? ?? ????	≤0.1%	0.06%
?? ???
?????(??)	≤0.1mg/kg	?????
??(??)	≤1mg/kg	?????
????????? ?????
???? ???? ???	≤1000cfu/?	?????
??? ?? ???	≤100cfu/?	?????
?????	????	????
?.??	????	????
?????	????	????
???????	????	????
????? ???
???: 25kg / ????
????? ??? ???? ?? ???? ?? ??? ???? ????? ?? ?????????? ????????? ????????? ??? ????? ???? ?? ??? ????? ????? ?????
??????? ????	3 ????