????? K1, ?????? phytomenadione ???? ?????

????? K1? ????? phytomenadione? chloromenadione? chloroquinone? ????? ???? ?????? 2-????-3-phytyl-1? 4-naphthoquinone? polycyclic aromatic ketone? ??-???? ????? ???? ?? ????? ????? ??? ?? ???? ???? ??? ??????? ????? ????? ???? ??? ???? ????.

????

???? ?????

????

????? ????? ?????? (??? ???? ?????? ???? ?????? ???? ????? ????) ??????? ?????? ???? ???? ??? ???? ??? ????? ???? ????? ??? ??? ???? ????? ??? ???? ??? ??? ???? ?????, ?? ???? ?????? ??? ???? ?????. ????, ????? ? ?????? ????? ???? ???? ??? ?? ???? ?????; ?????? ??? ??? ????? ?????? ??? ?? ?????? ??? ??. ?????? ????? ??? ?????? ?????, ??? ?? ????? ???? ???? ?????? ???? ???. ????, ?????? ? ???? ????? ??-??? ????? ?? ??? ??????.

????2

????? ?? ??????

1. ???? ????? ?????? ????? ?????? ??? 420 ~ 475μg / ?? ??? ????? ???? ??? ??? ?? ??? ????.

2. ?????? ? 1 ???? ?????? ? ???? ? thrombin ???? ?? ??? ????? ??? ???? ???? ?????? ?? ???? ??? ?? ????? ?????? ???

3. ??? ????? ???????

4. ????? ??? ???? ?????? ????? ??????.

5. ????? ??????? ?? ????? ????? ????.

???? ????

???? ??	????? K1; ????? ????? ????? K1
???? ??	???? ????	???? ????
???	?? ???	?????
???	≥98%	98.98%
??	???	?????
????? ?? ???		1.35%
???		1.6%
?? ????	????	?????
?? ??-??? ??????	????	?????
????? ????
?? ???		?????
????? (??)		?????
??(??)		?????
????? (??)		?????
???? (???)	???	?????
????????? ????
???? ???? ???		?????
??? ?? ???		?????
?.??	????	?????
??. ????	????	?????
?????	????	?????
??-??? ??????	????	?????
?????	?????? ?? ????