1. ???? ??????

???????? ???????? ???????? ??????????

???? ????????? ???????? ??????? ??? ????? ??????? ?? ???????????? ?? ??????? ???? ????? ?? ??? ????????? ??? ???? ??? ????? ????? ?????? ???????? ??????? ?????? ?????????? ????????? ??????? ????????? ??? ?????? ??? ??? ???????? ??????? ?? ???? ????? ???? ????? ????????? ????? ?????? (TET2) ?? ??????? ???????.

??????? ?? ???? ???? ????? TET2

??????? C? ???????? ?????? ??????? ?? TET2? ????? ?????? ??????? ?????? ???????????? ??? ????? ??????? ???????? ????? ????? ????? ????? ??????? ?????? ????? ???? ?????? ???????.

????? ?????????? "????? ??????" ?????????

?????? ????????????? ???? ?????? ?????? ????????? ?? ??? ????? ???????? ????????? ?????? ??? ???????? ???????. ????? ???????? ?? ?? ???????? ??????? ?? ?????? ??? ?????? ?????? ??????? ????? ????? ?? ????? ????????.

2. ?????? ?????????

?????? ?? ??? ??????? ????????: ?? ????? ???? ?????? ??? ????? ??? ??????? ?? ????????? ??????? ??? ????? ???? ?????? ??? ??? ?????? ????? 60%? ???? ????? ???????? ?? ??????? ????? 80%? ??????? ??????? ??????? ?????????? ????? 50%.

??????? ???????: ???? ??????? ?? ???? ?????? ??????????? (IFN)? ????? ???? ??????? ???????? ??? ?????? ??? ????????? ???????? ???????? ????? ????? ??????? STAT1? ??? ???? ??? ????? ????????? ???????? ??????? ?????.

3. ??????? ??????? ???????

?????? ??? ????? ?????? ???????: ???? ??? ???????????? ?????? ?????? ??? ????? ??? ???????? ??????? ?????? ????????? ???????? ??????? ??? ??????????? ????????? ??????? ????? ?????? ????? ?????? ?? ???? ?????? ?? ?????? ????? ??? ?????.

??? ???? ?????: ???? ??????? ??????? ??? ???????? ?????? ??????? ????? ?????? ???????? ?? ???????? ??????? ???????? ?????? ???? ?????? ?????? ?????? ????????.

???? ???????? ????????: ?? ????? ???? ????? ?? ???????? ??????? (??? ??????? ??) ?? ???? ???? ??? ????? ?? ??? ?????? ??? ?????? ??????? ?? ???? ?????? ??? ????? ???????? ???????.

4. ??????? ????? ??????????

????? ????????? ???????? ?????????? ???????? ??????? ???????? ?? ?? ???????? ??????? ?????? ??? ???? ??????? ??????????.

????? ????? ?????? ??????? ?? ??? ????? ?????? ??? ???? ??????? ????????? ???????? ???????.

????? ?????? ????? ????????? ????? ?????? ???? ??? ????????????-TET2