1. ??????? ??????? ???????? ????????

???? HMB ??????? ?????????? ?????? ?????? ??????? ?? ???? ????? ??????? ????? ????????:

?

?????? ????? mTOR ?: ????? ????? ????? ????? ????????? S6 ????? 38%? ?????? ????? ????? ????? ???????? ??????? ?????? ?? ?????????? ???????? ?

? ??????? ?????? ???????????? ?: ?????? ??????? ?? ?????????? ????? E3 MuRF1 ????? 41?? ???? ????? ??????? ???????? ????? ??????? ?

? ??????? ???????? ?????? ?: ????? ???? LC3-II/LC3-I ??? 1:1.5 ???? ????? ????? ??????? ?????? ?? ???????? ?????? ?????? ?

??????? ?????? ????????? ????? ???? ??????

???? HMB ??? ????? ??????? ??????? ?? ???? ???????? ??? ??????? ???????:

?

? ????? ???? ?????? ?: ????? ????? ?????????????????? ????? 27?? ?????? ?????? ??????? ?????????? ????? ??????? ?

????? ?????? ?????????: ????? ????? ??? ??????? ????? ?????? ?????? ????????????? ?????? ??? ????? ????????? ????? 63?

? ????? ?? ??????? ???????? ?: ?? ????? ???? Nrf2? ??? ??? ??? ????? ???? ????? ??????? ?????? (SOD) ????? 41%?

??????: ???????? ????????? ???? ???????

1. ????? ?????? ????? ???????

??? ????? ????? ??? ????? ??????? HMB ????? 3 ???? ?????? ??? ?????? ???? ????? ????????? (CK) ????? 44% ?????? ??? ???? ??????? ????? 51%

??? 72 ???? ?? ???????? ??????? ????????? ????? ???? ???? ?????? ?? Z ?? ????? ??????? ????? 62%? ?????? ????? ????????????? ???????? ????? 83%.

2. ????? ???? ??????

??? ????? ?????????? ?????? ??????? ???????? ?? ???? ????? 19% ????? ????????? ?????????? ?? ??????? ????? 27%68

??? ???? ???????? ???????? ???? ?????? 6 ?????? ??? ????? VO2max ????? 4.2% ?????? ?????? ??? ???? ???????? ???????? ????? 13%

4. ????? ?????? ???????

5. ??????? ?? ?????? ?????? ?????? ??????

?? ???? ???? ??????? ??????? ????? ????? ?????? HMB ???? 28 ?????? ?? ???????? ???? ?????? ???????? ?????? 1.3 ?? ????? ???? ???? ???? ?????? ??????? ??? ?????? ????? 31?

?? ???? ?????? ???????? ??? ???? ???? ???????? ??? ????? 47% ???? ??? ?????? ????? ???? ????? ????

2. ?????? ?? ???? ??????? ????????

??? 12 ??????? ?? ??????? ???? ???? ????? ??? ???? ???? ????? ???? ??????? ?? 70 ????? ?????? 0.15 ????? ?? ???????? ?????? ??? ?????? ????? 38?

???? ??????? ??????? ?????????? ???????? ????? 21% ?? ???? ?????? ??????? ?????? ????? 14% ?? ????? ????? ??????? ?? ????? ??????

5.???????? ?????????? ???????

???? ????? ??????

??? ??? ????? ????? ????????? ??? ????? ????? ??? ??????? ?????? 3.7 ???? ???? ???? ???? ????? ???? ??? ?? 7?

???? ?????? ??????? ?????? ????? ??????? ????? ?????? ??????? ????? ?? ????? ??????? ??? 15 ?????

??????? ?? ??? ??????? ?????????

?? ????? ????? ??????? ???????? ??? 8.7 ????/??? ??? ??? ????? ??????? ????? 62?

????? ????? CRISPR ???? ????? ??????? ????? 41?? ????? ??????? ???????? ???????

6. ??????? ???????

? ?????? ?????? ?: ?????? ??????? ??????? ?? ???? ???? > 5000 ???/??? ?? ???????? ??? ???? ?????? ?

? ??????? ???? ????? ?: ?? ??? ?????? ?? ???? ????? ????? ??? 12 ????? ?? ??????? ???? ???? ???? ???????? ?????? ??? ?? 3??

? ????? ?????? ?: ???? ?????? 3 ????/??? ??? ????? ?????? ?????? ?????? ???????? ????????

?????. ?????? ??????????

??????? ??????: ??????? ??????? HMB ??? ????? ????? ????? ?????? ??????? ??????? ???????

???? ????? ??????? ????????: ????? ????? ???????? ????????? HMB ??? ???? ???????????? ??????? ??? ????????? ???????