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?????? ?????? ???????? ??????? ?????? ????? ????? ??????? ?????? ?? ??????? ?????? (CMS). ??????? ??????? ??????? ?????? ?? ?????? ??? ???????? ??? ?? ??? ??? ????? ?????? ??????? ???????? ??????? ????? ??????? ???? 21 ????? ???????? ??????? ???????? ???????? ????????? ?? ?????? ????????. ?????? ??????? ??? ??? 21 ????? ?? ??????? ??????? ????? ??????? ????? ?????? ??????? ???? ????????. ?? ????? ????? ??????? (OFT)? ?? ????? ??? ???? ????? ?????? CMS ?? ??????? ???????? ?? ????? ??????? ???? ????? ??? ???? ??? ????? ????? ????? ?????. ?? ????? ????? ????? (TST)? ?? ????? ??? ?????? ??????? ?? ?????? CMS ???? ????? ??? ???? ??? ????? ?????? ??????. ?? ????? ????? ??? ????? ?????? ??? ??????? ?? ?????? CMS ???? ????? ??? ????? ????? ???? ????? ??? ???? ??? ?????? ?????? ??????????.

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??? ???? ???? ???????? ??????? ?????? ????????? ????? ??? ?????????? ?? ??? ???????. ????? ??????? ???????? ??????? ?? ????? ?????????? ?? ??? ????? ?????? CMS? ????? ?????? ???? ????? ??????? ?????????? ??????? 5-???????? ????????? (5-HT) ????????????. ????? ????? ????? ?? ??????? ?? mRNA ?????? tph1? ??? ????? ????? ?? ????? 5-???????? ?????????? ?? ????? ???? ????? ?? ????? ??????? ??? ????? ?????? CMS? ??? ???? ????? 5-HT ?? ??????? ??????? ???????. ???? ??? ??? ?? ??????? ?????? ????? ????? ?????? ?????? ???????????-5-HT ?? ?????? ??????? ???????? ??? ???? ??? ?????? ?? ??????? 5-HT ???????.

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??? ????? ?? ?? ?????????? ?? ?????? ???? ?????? ?????? ??????? ???????? ??? ?? ???????? 5-HT ???? ????? ????? ????? ???? ?? ?????? ?????? ???????? ?????? ?? ????? ?????? ?? ???????? ??????????? ??? ?????? ???????? ?????? ??????. ???? ???????? ????? ???????? ?? ??????? ?? ?????? ?? ????????? ??????? ????????? 5-HT ???????? ?? ????? ?????? ?? ????? ?? ??? ??????. ?????? ??????? ?? ??????? ?????? ???? ???? ????? ?? ??????? ?? ????????? ??????? ??????? ??????? ??? AgRP ?OX1R? ????? ???? ?? ??????? ?? ??????? ??????? ??????? ??? LEPR ?MC4R ?5-HT1B. ???? ??? ??? ?? ?????? ???? ??????????-5-HT ?? ???? ??? ???? ????? ??? ????? ?? ???? ??????? ??? ??????? ??????? ?? ????? ?? ??? ??????.

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????? ?? ????? ????????? ?????????? ?? ?????? ?? ???????? ?????? ????? ????? ??????? ?? ??????? ??????? ?????? ?????? ?? ?????????? (100 ???/?? ?300 ???/??) ?????? CMS ?? ???? ??????? ????????? ??????? ???? 21 ?????. ????? ??????? ??? ??? 21 ????? ?? ?????? ????? ????? ?? ?????????? (300 ???/??)? ????? ???? ????? ????????? ??? ??????? ?? ????? ????? ??????? ?????? ????? ????? ???? ?????? ??? ????? ??????? ??? ???????? ?? ????? ?????? ?????? ?????. ????? ?????? ???? ?? ?????? ?????? ????? ?? ?????????? ????? ?? ?????? ????? ????? ????? ????? ?????? ??? AgRP ?OX1R ?? ????? ??? ?????? ????????? ???????? ??????? ?? ??????? ??????? ?? ????? ????? ?????? ??? LEPR ?MC4R ?5-HT1B ?5-HT2C. ??? ?????? ?????? ??? ??? ????? ?? ?? ???????? ???? ?????? ???? ?????? ?? ?????????? (100 ??? / ???) ?? ???? ?????? ?????? ?? ???????? ????????? ??? ??? ??? ???? ????? ???????? ?? ??????? ?????? ??????? ??????? ?? ????? ?? ??? ?????? ??? ??????? ???????.

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????? ?????? ???? ?????? ???? ?? 5-HT? ?? ???? ??????? ????????? 5-HT1B ?5-HT2C ??? ????? POMC ?AgRP ?? ????? ??? ??????? ???? ????? AgRP/NPY ???? ???? ??????? ????? ????? POMC ???? ???? ?????? ????? ??????? ??????? ?? ???? ????? ?? ????? ?????? ??????. ???? ??? ????? ????? ?????? ???????? ?????? ??????? ???????? ?? ???? ???? ?????????-5-HT.

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?????? ???????? ????? ????? ????? ????? ??? ?????? ??? ????? GT1-7 ?????? ???? ???? ?? ??????? ???????? ?? 5-HT ??? ????????? ??????? ???????? ???????. ?????? ????? GT1-7 ?? 10 ?????????? ?? ??????????????? (CORT) ???? 24 ???? ??????? ????? ??????? ??????. ????? ??????? ?? ??????? ?? ??????? ??????? ?????? ??? AgRP ?OX1R ?? ????? ???? ????? ?? ???? ???? CORT? ????? ????? ??????? ?? ??????? ??????? ?????? ??? MC4R ?5-HT1B ?5-HT2C. ??? ???????? ??????? ?? 0.1 ?????????? ?? 5-HT ???? ??????? ???? ??? ??????? ??? ??????? ?? AgRP ?????? ???? ?????? ?????? CORt ???? ????? ???????? ??????? ?? MC4R ?5-HT1B ?5-HT2C. ??? ??? ??? ???? ???? ??????? ???????? ??????? ?? 5-HT ??? ??????? ??????? ??? ??????.

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??????? ?????????? ??? ?????? ?????? ?? 5-HT ?? ????? ??? ?????? ??? ????? ??????? ??????: ?????? ??????? ?????????? ?5-HT ?? ????? ???? ????? ??? ????? ?????? ?????????? (P

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???? ???? ???? ??? ??????? ?? ?????? ?????? ????? ????? ?? ???? ????? ?????? ?? ????? ??? ?????? ?? ???? ????? ?????? ?????? ???????????-5-HT? ????? ????? ????? ????? ???????. ????? ????? ?????? ??????????? ???????? ?????? ?????? ????? (300 ???/??)? ??????? 5-HT ????????? ?????? ???????? 5-HT1B ?5-HT2C ?? ????? ??? ??????? ?????? ??????? ??????? AgRP/NPY? ?????? ??????? ??????? POMC? ??????? ???????? ?????? ???????? ??????? ???????? ????? ??? ????????.

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