????? ??????? ??????? ?? ?????? ??????? ???? ????? ?? ??? ??????? ?????? ????? ?????? ??????? ?????? (??? ??????? ?? ???????? ??????? ???????)? ????? ?? ???? ????? ????? ?? ????? ????? ??????? ?? ??????? ???????? ???????. ????? ??? ?????? ????????? ???? ???? ???? ??? ???? ?? ?????? ??????. ?? ???????? ?? ???????? ???????:

?

1. ?????? ??????? ??????? ???/???????

??????? ?? ???????? ??????? ??????? ???????? (rUTI) ?

??????: ???? ????? ??????? ?? ???? ???? ??? ????? ????? ???? ?? ?????? ??? ???? ???? ?????? ?????? ???? FimH pilin adhesins ?? ?????? ??????? ??? ????????? ????????? ?????? ??????? ???????? ??? ???? ????????? ?? ????????? ??????? ???? ?? ???? ?????.

?????:

??? ????? ?????? ?? ???????? ????????? ??? ???????? ?? ?????? ?????? ???????????? ?? ????? 1.5-2 ???? ?? ??????? ?????? ?? ??? ?????? ???????? ??????? ?????? ?????? ?? ??????? ?? ?????? ??????? ??????? ?????? ?? ????????? ????????? ??? ??????? ??? ??? ??? ???? ????????.

????? ??????? ??????? ????????? ?????? ??????? ??????? (EAU) ????? ??????? ?? ???? ??????? ??????? ???????? (????? ??????: ?).

???????: ????? ????? (???? ?????? ????? ?? ?????? ??????)? ?? ???? ??? ?????? ???????? ??????? ????? ??????.

??????: ????? ??? ??? ??????? ??? ???? ?? ??? ??? ???????? ??????? ?? ???? ?????????? ??????? ?????? ??? ?????? ??????? ??????? ??? ????????? ????????? ?????.

2. ?????? ?? ????? ????? ???? ??? ??????? ?????

???? ?????? ???????? ?????? (CDG)

?

??????: ??? ??????? ??????? ?? CDG? ??? MPI-CDG (??? CDG-Ib)? ????? ??? ????????? ???????????? (PMI)? ???? ???? ????? ???????-6-?????? ??? ????????-6-??????? ??? ???? ??? ??? ??????? ????????.

??????: ???? ?? ???? ????? ??????? ?? ???? ???? ??? ????? ???? PMI ?????? ???????-6-?????? ???? ?????? ???????? ????? ?????????????.

????? ??????:

????? ????? ?????? ??????? ??? ??????? ??????? ????? MPI-CDG? ??? ??? ??????? ??????? ??????? ??????? ?????? ?? CDG.

???? ????? ?? ????? ?????? ??????? ??????? ?????? ?????? ??????? ???? ???? ???? ??? ????? ?????? ??? ??????.

?????????: ??????? ?????? ???????? ???????? ?????? ????? ???? ?? CDG? ??? ALG-CDG.

????? ??????? ??????? ??????? ?????? ??????? ???? (??? ????? ???)

?

??????:

?????? ????????? ?????: ???? ??????? ???????? ???????? ?????? (TAMs) ???? ???? ?? ???????? ??????? (MRC1)? ????? ????? ??????? ??????? ???????? ??? ??????? ?????? ???????.

????? ????? ???????: ???? ??????? ???? ?????? ???????? ??????? ??? ??? ??????? ?????????? ??? ???? ?????? ??? ??????? ??????? ??????? ??? ??? ??????? ?????????? ??? ?? ???? ????? ???????.

????? ?????? ?????? ?????????: ?? ???????? ???? ????? ??? ?????????? ???? ?? ???? ????? ??? ??????? ??????? ????????? (??? ??????????????) ??? ????? ??? ????? ???? ???? (???? ?? ???? ?????? ?? ????? ??????? ??????? ????????).

??????: ???? ???? ??? ????? ?????? ?? ?????? ??? ?????? ?????? ??? ?????? ??????? ??????? ?????? ???????.

???? ?????? ????? ????????/????????? ??

?

??????: ????? ?????? ???????? ??? ??????? ??????? ?????????? ??? ???????? ??????? ?? ??????? ??????? ???? ???????. ???? ??????? ?? ???? ????????.

???:

??? ????? ??????? ????????? ?????????? ?? ??????? ???? ?? ???? ?????? ???????? ???????? ????????.

????????? ??????? ?? ??????? ??????? ???????? ???? ?? ???? ?? ???? ??????? ???????? ???????? (??????? ??? ?????????).

?????????: ?????? ?????? ?????? ??????? ??????? ?????? ???????? ?????? ?????? ???????.

3. ??????? ????????? ??????? (??????? ??????)

??? ?????? ??????? (IBD) ?????? ?????? ?????? ??

?

??????:

?? ???? ??????? ??? ????? ???????? ??????? (????? ????????? ???????) ?????? ?????? ????????? ??????? ???????.

????? ????? ???????? ?????? ??????? ?????? ?? ???? ????? ??????????.

????? ??????: ???? ??????? ????????? (?????? ???????) ??????? ?????? ?????? ??? ??????? ??????? ??? ?????.

????? ????? ??????? ??????? ??

?

???????: ????? ??? ?????????? ????? ?????? ??????? ??????????? ??????? ??????? ?????? ????. ?? ????? ?????? ??????? ???? ??????????.

??????: ?? ??????? ??? ?? ????? ??????? ?? ?? ??? ???? ???? ?? ???????? ??? ????? ????? ?????? ?????.

??????? ?? ??????? ??? ?????? ??

?

??????: ???? ?????? ??? ???? ??? ????? ????? ?? ???????????? ??? ????????? (AGEs) ??????????? ??? ???? ???????. ?? ????? ??? ??????? ??? ????????? ??? ???? ??? ????? ????? ?? ????? ?? ?? ???? ???? ?????? ?? ????? ???????????? ??? ?????????.

??????: ???? ??????? ??? ????????? ?? ???? ?????? ?????? ?????? ??????? ????? ?? ???? ??????? ??????? ?????.

4. ???????? ???????

???????? ???????? ?? ??? ??????

?? ??????? ?? ???????? ??????? ??????? ??? ????? ?? ?????? ??????? ??? ????????? ?????????? ?????? ??????? ??? ????? ?????? ??? ????? (????? ??????? ??? ????? ?????)

???? CDG ???? ??? ?????? ????? ?????? ????? ??????? ?????? ??????? ??? ??????

?????? ???? ????? ?? ??? ??????? ??? ??????? ?? ???? ??????? ??????? ???????? ??? ????? ????? ?????? ??????? ?? ????? ??? ?????? ?????????

??? ????? ?????? ????????? ?????? ?????? ???????? ??????? ??????? ?????? ??? ????? ?????? ?????? ?? ??????? ????????

??? ??????? ??? ??????? ?? ???????? ??????? ??????? ??? ???? ????? ?????? ????? ??????? ??? ?? ???? ?????? ?? ????? ??????? ????????

5. ????? ??????? ??????????

????? ???? ????? ????: ????? ?????? ?????? ????? ???????? ?????? ??????? ?????/????? ???????.

????? ?????? ??????: ??????? ????????? ???????? ??????? ?? ???????? ??????? ??????? ???? ??????? ???????? ???????? ??????? ????????.

????? ???? ??????? ???????: ????? ????? ?? ?????? ?? ??????? ??????? ?? CDG ????????? ????? ??????????? ???? ???? ?????? ????????.

?????? ????? ??????? ?????? ???????: ??? ????? ????????? ??????? ??????? (??? ????????? ?????? ??????? ?? ???????? ??????? ???????).

?????????? ????? ??????: ?????? ?????? ????? ??? ??? ?????? ?????? (?????? ??????? ???????) ?? ???? ??????? (CDG)