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???????? ??? ???? ?????? ????? ???? ???????? ????? ??? ?????? ????? ??? ????? ???? ??????? ?? ????? ????? ????? ?? ???????. ????? ???? ?????? ?? ??? 30% ?60% ?? ????? ????? ????? ??????? ??? ????? ??? ???? ???????? ??????? ?? ?????? ???????? ???. ?????? ?????? ??????????? ???????? ?? ?????? ??? ????? ??????????? ????? ??????? ??? ???? ?????? ????? ?????????? ???????. ??? ??? ?????? ?????? ?? ???? ???? ?????? ??????? ????? ???? ????? ?? ????? ????-1? 3? ?????? ??? ???? ????? ?? ????? ????? ????-1? 6.

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????? ????? ???? ?????? ???? ????? ???? ????? ?? ??????? ??????? [6]:

1) ?????? ??????? ???????: ????? ???? ?????? ?????? ????? ???????? ????? ???? ?? ???? ????? ???????? ?????? ?????? ???????? ????????? ?????? (ROS) ????? ?? ????? ??????? ???????? ??? ?????.

?) ????? ????: ???? ???? ??????? ??????? ????? ???? ?????? ????? ???? ??? ??? ?????? ??? ??????? ?? ??? ?????? ????? ???? ????? ????? ???????? ???? ?????? ?????? ?????? ??? ?????? (TEWL). ??? ?????? ???? ????? ??? ??? ?????? ??? ?????? ??? ?????? ??? ?????? ???????.

?) ????? ????? ?????? ??? ??????: ??? ??? ?????? ?? ????? ?????? ?? ???? ?????? ???? ?? ???? ???? ??????? ??????????? ??????? (HaCaT) ????????? ??????? ??????? ??????? (HDFa)? ??????? ?????? ?????? ?????? ????? ??????? ?? ????? ??????? [7]. ???????? ??? ???? ????? ????? ???? ?????? ??????? ?????????? ???????? ?????? ??? ????? ???????? ????????? ?????? ?????? ????????. ????? ????? ????? ?? ???? ??????? ??????? ???????? ?? ???? ?????? ?????? ???? ????? ?????? ????? ??????? ?????? (????????) [8].

?) ??????? ????? ????????: ????? ???? ?????? ??? ????? ?????? ?????? ?????? ??? ???????? ???????. ??? ???? ????? ????????? ??????? ???????? ???? ??????? (ECM) ?????? ?? ?????? ??? ???? ?? ??? ????? ???????.

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