Youdaoplaceholder0 1.1 ???? ???????? ?????? ????? ?

?????? ??????? ??? ????? ?????? ??????, ???????????????? ??????????? ?????? ???????? ??? ???????????? ???????? ?????????? ??????: ????????????? (???? ??????? ??? ?????????), ??????????????? (???? ????????), ??? ????????????? (???? ???????)? ??????, ????????? ???????? ??? "????? ??????" - ??? ???? ????? ??????? ????????????? ??? ??? ??? ????????? ???? ???? "?????????? ??????"?? ???????? ???? ?????? ???? ??? ???? ???????? ??????? ??? ???????? ??????? ????? ???????? ?????????? ??????? ????? ????????, ??? ???????????????? ??-???? ????????????? ?????????? ??????? ??? ???????? ?????? ???????? ??? ??? ????????? ??? ???????????? ????????????? ??????????????? ????? ?????? ???? ????

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Youdaoplaceholder0 1.2 ?????????? ????????? ???? ??????????? ?????????? ???????? ???????????

????-?? ????? ?????? ????, ??????? ????????? ???????? ??? ?? ??????? ??????????? ????????????? ????? ???????? ??????????????????? ??? ??? ?????????? ??????? ???????? ???? ????? ?? ??????????? ??? ??????????? ??????? ????????? ?????? ?????? ?????? ???? ??????? ?????? ???? ????? ????? ???????? ????????? ??????? ???? (CRUK) ?????? ???????? ?? ??????????? ???????? ????????? ?????????? ?????????? ??? ???? ???????? ???: ???????????? ??????????? ???? ????? ?????, ?????? ??? ??% ??????? ??? ???? ?????? ??????? ??? ??% ??? ???? ??? ??????????? ???? ???????????? ???? ????? ???, ??????? ????? ????? ??????? ?.? ??? ?????? ????? ?? ???????? "????? ?????? ??????????? ??????? ???" ?? ??????? ??????? ????? ????????

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Youdaoplaceholder0 ??????? ? ?????????-?????? ??????????? ???????: ????? "????? ??" ???????? ???????? ? ???? ????

Youdaoplaceholder0 2.1 ???????? ??????????: ????????? ???????? "??????? ????" ?

?????? ????? "?????????? ??????" ????? ??????? ??????? ????????? ????? ??????? ????? ???? ???? ????? ???? CRUK ??? ??????-?? ??????? ??????? ?????????? ??????? ???????? ????? ?? ??????? ??? ????? ??????? ?????????????? (GLUT1/3) ?? ??????? ????????? ???? ????????? ???? ???? ??? ??? ????????? ???? ???, ???????? ??, ??? ??????????? ?????? ????? ???????????? ???? ???????-?-????? (M6P) ?? ????? ???? ?? ???????? ??????????? ????????????? ???? ????? ?????? ???? ???? ?? ??? ????? ????? ??? ???? ???? "???????? ????" ???? ???, ??? ??? ATP ????????? ???? ?????? ??? ??? ??????????????? ???????? ???????? (ROS) ???????? ???, ?? ??? ??????? ????????? ????? ?????????????? ??????? ??? (????? ?)?

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Youdaoplaceholder0 2.2 ?????????? ??????????: ????????? ????? "????? ???" ????????? ?

???? ????, ????? ???????????????? ??? ????? ?????? ???? ?????? ?? ??? ?????? ??? ?? ??????? ???? "???????? ???????" ?????? ??? ???? ????? ???????????? ??????? ?????????????????? (PDAC) ?????, ??????? ??????? ??????? H3K27 ?????? ????????????? ???? ??????????????? ????? ???, ??? ??? MYC ??? KRAS ????????? ???????????????? ????????? ?????????? ???? ??? ??????????????, ?? ???? ??????????????? ?????? ??????? ??? - ????? ??? ???? ??????? ???? ??? ???, ???? ????????? ??????? ?? ????????????? ????? ????, ?? ????????? ???????? ???? ???? ????? ?????? ????

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Youdaoplaceholder0 2.3 ????? ???????????????????? ????????????: PD-L1 ? ?? "????-???? ???????" ????? ???

??????? ???????? ??? ?? ???????? ????? ?? ??????? ?????????? ??? ????????? 1 (PD-L1) ?? ????????????? ????????? ????????? ??? ???????? ??? ???????? ?????? ??????? ?????????? ???? ????? ????? ?? ??????????????? ????????? ???? ???? ?? ??????? PD-L1 ????????? 192 ????? ???????? ?????????????? N-??????????????? ???? ????, ??? ??? ??? ???????? ???? ???? ??? ????? ???????? ?????? ???? ????? ???? PD-L1, ?? "????? ?????" ?? ??????? ??????, E3 ubiquitin ligase FBXW41 ?????? ?????????? ??? ????????? ?????? ?????? ???? ???????? ???????????, ??????? ??? ????????-PD-1 ???????????????? ???????? ???????? ?????? ???????? ??? 28% ???? 79% ? ?????? ??? (????? 2)?

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Youdaoplaceholder0 ??????? 3 ???? ???? ???? ??????? ??????????? ????????: ?????????? ???????? ?????????? ?? ?

Youdaoplaceholder0 3.1 ??????????????? ??????? ?????? ??? ?????????? ?

CRUK-?? ?????????? ????????? ?????, ???? ????????? ???? ????????? ???????? ??????? ???????? ??????, ??? ???????? ??????? ?????? ?????? ???????? ??????, FOLFIRINOX ?????????? ??????? ???? ????? ???, ??????? ????? ????? ??? ???? 42 ??? ???? 98 ??? ??????? ??????? ??????? ??? ?????????? ???? ?????? ?????? MD Anderson Cancer Center-? ??????-??????? ???? ????????? ????? ?? ??????? ??????????? ??? ???????: ??????? ??????????????????? ?????? ????? ??? 45% ???? 72% ??????? ??????????? ???, ??????? ??? ??????? ?? ?????? 15% ?????? ????????? ????? ????? ??????? ??? ????????? ???? ???? ?? ?? ????-????????? ??????? ???????????? ???????? ???????-????? ????????? (PMI) ?????? ???, ?? M6P ?? ?????????-6-?????? ???????? ???? ???? ??? ????????????? ???? ???? ??????? ????? ?????? ???? ?????

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Youdaoplaceholder0 3.2 ???? ???????? ???? ????? ????? ?

???? ???? ???? ???? ????????? ????? ????? ??????????? ???????? (NCT05220739) ?? ?? ?????? ??????????? ??? ?????? ????? ???????? ?????? ????? ???????? ???? ???? ? ????? ????????? ????? ????? ????????? ??? ??????, ? ?? ????? ???????? ?????? ????? (ctDNA) ?????? ??% ??? ???? ????? ???????, ??? ????? ???? ????????? ????????? ????? ????? ??????????? ?????? ??% ????? ???????? ???, ??? ??? ?? ?????? ????? ???, ??? ? ?? ????? ????? ????? III ????????? ???? ????, ?? ?????? ???? ?? ????????? ?????? ????????? ??? ?????? ????????, ??????-???????? ????????????? ????????? ??????? ??? ????? ??????? ????????????? ????? ??? ????? ??????????????? ???? ?????? ?? ????? ??????-??????????? ???????? ?????? ??% ? ??????? ??? ????? ????????? ??????????????? ????? ????????

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Youdaoplaceholder0 ??????? ? ????? ???????? ??? ??????: ?????? ???????? ??? ????????? ?

Youdaoplaceholder0 4.1 ??????? ?????????? ?? ?????? ????? ?????? ??? ?

????????????? ???? ??? ??????? ????????? (?????? ????? ????)

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?????????-?????? ????? ????????????? ???? ??? ???? (????????)

???????? ?? ?????? ?????? ???

??? ??? ????-? ???????????), ?? ?????????-?????? ????? ????????????? (???????? ??-?? ?????) ???? ??? ????? ????????? ???????? ???????? ???????????????????? ?????????? ????????? ???????-? - ?????????? ????? ???????????? (??????) ?? ???????? ??? ??? ?? ?????/?????? ?????????? ??? ??? ??/?????? ?????? ?????? ??? ????? ????????? ???? CRISPR-Cas9-???????? Saccharomyces cerevisiae ???????????? ???????????? ??????? ????? ???? ???? ????????????? ????-????????? ??????? ???? ???? ????? ???????

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Youdaoplaceholder0 4.2 ?????????? ???????? ??? ????????? ????????????? ????? ???? ?

"?????????-?????? ????" ??????? ???????? ?????? ???? ????, "???????? ?????? ???????" ??? ???? ??? ?? ?? ??????? ????????? ???? ???????? ???????????? ???????? ??????, ??? ??? ????? ??????? ???????? ???? ????, ??????? ????? ???? ???????????? ????????? ???? ???? ???, ??? ????? ??? ?? "????????????? ??????????? ????? ??? ?????????? ???????? ???? ??? ???? ????" ?????????? ???????? ?? ???????? ????????? ???? ?????? ????? ???????? ???????? ?????? ???? ???? - ????????? ????????? ???? ???? ?? ???????????? ??????? ??? ??????????????????????? ??????????-? ????????? ??% ????? ???? ??? ????????????????? ?????????????? ??????? ?????? ????? ?????? ??????????? ??????????? ???????? ???? ?????????? ??????????

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Youdaoplaceholder0 ????? ??????? ??????? ????????: ???????-??????? ?????? ????? ?????? ?

Youdaoplaceholder0 5.1 ???????? ???????? ?????????? ?????? ?

???????? ???????? ??????????? ??? ?????? ??? ???????????? ??????? ???? ?????? ?????? ??????? ?????????????? ???? ?????????? ?????? ???? "??????? ??????????? ?????" (MSS) ?????? ?????? ???????? GLUT1 ?? ?????????? ????, ??????????? ????????? ??? PMI ??????? ?????? ?????? ??? ??????? ????????? ????????????? ???????? ????????? ???? ????? ???????? ????????? ????????? ?????????? ??????, ≥75% MSS ????? ?? ?????????? ????????? ??????? ???????? ???????????? ??? ????? ???? ???? ????????????? ???? ?????????? ?????? ????

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Youdaoplaceholder0 5.2 ????? ????-?????? ????? ????????????? ???? ?

????????? ????????? ??? ???????? ?? ???????? ??? ??????????? ??????? ?????? ??? ???? "???????-?????????????????" ??????? ?????? ?????, ?? ??????????? ?????? ??????????? ?????? ??????? ???? ?????? ??? ?????? ????????? ???? ?????? ????? ????? ???? ????????? ??????????, ?? ????????? ??????-????? ??????????? ?????????? ??????????????????? ????? ?????? ???? ??? ??? ?? ???????????????? 60% ????? ???????? ?????? ?????? ?? ?????????????? ???? ?????? ?????? ?????: ????????? ?????????????? Ce6 ?? ???? ??????? ???, ???? "????-??????? ??????????? ??????" ???? ??? ?????? ?? ????????-????????? ??? ?????? ??????? ??? ???? ????, ?? ???? ?????? ?????????? ???????? ???????? ????

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Youdaoplaceholder0 ???????: "?????? ???" ?????????-?????? ????? ????????? ???? ?

????? ??????? ??? ????????? ??????? ???????? ??? ????????? ?????????-?????? ?????? ???? ??????? ?????????? ???????? ????????? ???? ??? ???????? ?????? ??????????, ????????? ???? ???????? ?????? ???????, ?? ????? ??? ?????????? ?????? ?????? ??????? ?????? ?????????? ???? ???? ?????? ???? ??????????????? ???? ???? ??? ????????????, ???? ?????????? ?????????? ??? ?????????? ??????? ??? ??????????? ????????, ????????? ?????????? ???? ???? ???? ??? ???? - ???? ????? ?????? ???? ??????? ??????, "??????????? ?????? ?? ??????? ??????, ??? ????????????? ?????? ?????? ?? ???????? ????????? ??????? ?????????? ???? ?????" ??????? ??????? ??? ????????? ???????????? ????? ???? ?????? ?????, ?? "?????? ??????" ????????? ???????? ???? ???? ????? ????? ???? ?????