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- ???? ?????? ???????? ?????? ???? ?????? ??? ???? ?????? ?????? ???????, ????????? ???? ???? ??? ?????? ?????? ??-???????, ?? ???? ??????-?????? ??????? ???????? ??????? - ??-??????? ???????? ??? ????
??-??????? ????? ??????? ????? ??? ???????, ??? ???? ???? ????????? ??????? ?? ????????? ?????????? ?????? ????? ??????? ??? ??????????? ???????, ??-??????? ??? ????? ?????? ??? ?????? ????????? ???????? ????? ?????????? ???? ????? ?? ?????? ????????? ?????? 60%, ??? ???? ??-???????? ???????? ????, ?????? ??????? ???? ??????????? ????????????? ????, ?????????? ???? ??? ????????-??????? ???? ??????? ????? ???, ?? ????????? ?????? ???????? ?????????????, ??? ??????? ??????????? ????? ????? ???? ??-????????? ?????? ?????? ??????? ??? ???? ????; ??? ????, ?? ??????????????????, ??????-?????? ??? ???????? ??????????? ?????, ?????????????? ?????? ??? ?????????? ????????-?????? ?????? ?????????? ??????? ???? ???????????????, ??? ?????????? ???????? ????????? ??? ???????? ???? ???? ?? ??-??????? ????????? ???????? ??? ????? ????, ?????????? ????????????? ??????? ???? ????, ???????? ?????????? ?????? ???????? ???? ???? ??? ????? ????????? ??? ?????? ????????????? ??????? ?????????? ???? ????? ?????? ?????
?????????? ?????????, ????????????? ????? ??????? ???? ????, ????? ?????? ???? ???? ??-??????? ???????? ???????? ???????? ????? ??????? ?? ???????? ????? ?????? ??????? ??? ??????????? ?????? ??? ???????? ?????? (???? ??-?????????) ?? ??-???????? ?????????? ??? ???, ??? ???? ??????, ???????? ??????? ??? ?? ????? ?????? ???????
???? ????? ???????? ?????, ??-??????? ????????? ?? ???? ?????? ??????? ????? ????? ??? ???? ???, ???????? ???????? ???????? ????????? ???????? ???? ??????? ??? ?????? Escherichia coli ??????? ??? ???????, ?? ?????? ?????? ????? ?????? ?????? ????????? ?????? ??????? ????????, E. coli ?????-?????? ??????? ??? ??? ??? ?? ????????????? ?????? ??? ?? ??????????? ?????? ???????? ????? ???? ???? ?? ?????? ???????? ????, ?????????? ?????? ?????? ??????? ????????? ???? ????? ??? ???????, ???? ???? ??????? ??? ?????? Bacillus subtilis ?? ???? ???? Bacillus subtilis ?? ?-???????, ?????????, ??????? ?????????????????????, ??????? ???? ??? ??? ??? ???? ???????? ?????? ???? ??? ??? ??? ?? ??????????? ????? ??? ???? ?????? ?????? ?????? ??? ???????????? ????? ??, ??? "?????????? ?????? ?????? ???????" (GRAS) ??????? ?????? ?????????? ??????? ?????? ?? ????? ????????????? ????????????? ???? ????
?? ????????, ?????? ??? ???? D-mannose ??????????? ?????????? ??????????? ????? ???, ?????? ??????? ??????????? ????????? ??? ???????? ??? ??????? ??? ????????? ????????? ?????????? ?????? ??? ???????, ??? ?????????????? ??????? B. ???????? 168/pMA5-EcMIaseA ??????? ???? ??? ???????? ??-????????? ?????????? ?????? ??????? ??? ???? ????? ?????? ?????? ????????? ??? ???????? ???????? ?????????, pH ??? ?????????? ??????? ????????? ??? D-????????? ???????? ??? ??? ??? ????? ??? ???????? 5 L ??????????? ???? 27% ?? ???? ???????? ??? ??? 160 g/L ?? ???? ??? ?? D-????????? ???? ?????????? ????? ???? ?? ????? ???? ?????????? ?????? ??????? ???? ??????, ??? D-????????? ????? ???????? ???? ????????? ??????????? ???????? ?????? ?????????????? ?? ?????? ????? ?-???????, ??? ????? ?????? ??? ??????? ????????? ??????? ??????? ??????? ?????? ?????? ????? ??????????? ??????????? ??? ????????????? ????? ??????????? ???????? ???? ????, ??-????????? ????? ???????? ????? ?????????? ???? ????? ????????, ?????? ??????? ???? ???? ??? ?? ??-??????? ??? ???? ???????? ???????????? ?????? ???? ???? ??? ????????? ??????? ???????? ???? ???????????? ????? ???? ????? ??? ????, ???? ??? ??? ?? ?????????? ??-????????? ??? ???????? ??? ??????? ?????????? ???????? ??????? ??????? ???? ?????? ??? ?????? ??? ??????? ??? ?????? ??? ???? ???????