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?????????? ????????? ?????? ????????? ???????? ??????? ??? ????????? ????????????????? 5-????????????????????? (5-HT, ?? ????????? ????? ??????) ?? ?????????? ?????? ???????? ???? ???? ?? ?????????? ???????? ?????????? ??????? ?????? ????? ???? ?????????? ?????????, ???? ????????, ??????, ????????????? ???????? ??? ?????, ?????????? ??? ?? ???????? 5-HT ?????? ??? ?????? ???????? ???????????? ?????? ?????, ???????????? ????? ???????????, ?? ?????????? ????? ???????? ???? ?? ???????? ?? ?????????? ???-???????? ????????????? ???? ?????????? ?? ?????????? ?????? ????, ??????? ????????? ???????-????????? ???? ????? ???????? ???????

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??????, ??????? ????? ??????? ??? ???? ???????????? ???-???????? ?????? ??????? ???? (CMS) ???? ????? ???? ?????? ????? ???????, ??????? ????? ?????? ???? ???? ???? ?? ??? ??? ??????????? ??????? ????? ????? ??????????? ????? ???????? ????, ???? ????????, ????? ??????? ??? ?????? ??? ????? ???? ?????? ???? ???? ?? ?? ??? ???????????? ????? ???, ????????? ??????????? ?????? ??? ????????? ??? ???? ???????? ???? ???? ????? ????????? (OFT), ???? ????? ?????????? ??????? CMS ??????? ???????? ????? ???? ??????????????? ????? ??? ???????, ?? ?????? ??? ?? ????? ???????? ?????? ?????? ???????? ??? ?????? ????????? (TST), CMS ??????? ???????? ????????? ???? ??????????????? ????? ??? ???????, ?? ?????? ?????? ??????? ??????? ???? ??? ?????, CMS ??????? ???????? ????? ????? ??????????????? ?????? ???????, ??? ??? ??????????????? ????? ???????, ?? ?????? ??? ?? ????? ?????? ??? ????? ?????? ???????

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?????????, ??????? ???? ?????? ?????????? ???????? ???? ???? ??????????? ???????? ???????? ????? ?????? ???? ???? ?? CMS ??????? ??????? ????? ???????????? ?????? ??????????????? ????? ???????, ???????? ??????????? ??????????? 5-????????????????????? (5-HT) ??? ???????????? ?????? ??????????????? ?????? ???????? ??? ????????? ???? ???? ?? CMS ??????? ??????? ???? ???????? 5-??????????????????????? ?????????? ???? ??? ?????? tph1 ?? mRNA ?????????? ??????????????? ????? ??????? ??? ????? 5-HT ?? ??????? ????????? ??????? ?????????? ??? ?????? ???? ?? ???????????? ??? ??????? ???????? ?????????? ??????????-5-HT ???????? ???? ???????????????? ?????? ???, ??? ??? ????????? 5-HT ?????? ????????????? ???? ?????

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???? ???????????? ?????? ????-?????????? ???? ??????? ???? ???? ??, ???? ?? ?????????? 5-HT ?????????? ?????????????? ????????????????? ?????? ???????????? ?????? ???? ??? ??? ?????, ????? ??? ??????? ??? ???? ????????????? ?????????? ??????????? ?????? ??????? ??????????????? ?????? ??????????? ????? ??? ??????? ???????????? ??? 5-HT ?????????? ???????? ???????????? ??? ???????? ??????? ????????? ?????? ?? ???????????? ??? AgRP ??? OX1R ?? ??? ?????? ?????????? ?????????????? ???????? ??????????????? ?????? ???, ???????? LEPR, MC4R ??? 5-HT1B ?? ??? ?????? ???????????? ????????? ???????? ????? ???? ??? ??????? ???? ?? ??????????-5-HT ???? ??????? ?????????????? ?????? ????????? ???????? ??? ?????????? ????????? ?????? ???? ???????? ???? ?????

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?????, ?????????????? ??????? ?? ???????????? ???-???????? ????? ??? ??????? ?????? ???????????? ??? ???? ????? 21 ??? ??? ????? ??????? ?????? CMS ??????????? ???? ??? ???????????? (100mg/kg ??? 300mg/kg) ?????? ???????? ?????? ???? ???? ?? 21 ??? ??? ???? ??????? ???????????? (300mg/kg) ????? ??????????? ??, ???? ????? ??????? ??? ??? ???????? ????????? ???????? ?????? ??? ????????? ??? ???? ??????????????? ????? ??????, ??? ?????????????? ????? ????? ?????? ??? ??? ????? ?????? ??? ??????? ??? ???????? ???? ???? ?? ????-??????? ???????????? ????????? ???????????? ??? ?????? ????? ??????????????? AgRP ??? OX1R ?? ??? ?????? ?????????? ????????? ???????????? ???? ???? ????, ??? ???? LEPR, MC4R, 5-HT1B ??? 5-HT2C ?? ??? ?????? ???????????? ????????? ?????? ?????????? ???? ????? ??? ???????? ?? ???? ?????????????? ?? ?????? (??? ?????????/????) ????? ?????? ?????????? ??????????? ?????? ????????, ???? ????? ????? ?????????????? ?????? ????????? ??? ???????? ?????????? ??????? ????

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??? ????? ?????????? ???????? ???? ???? ?? 5-HT, ?????????????? POMC, AgRP ??? ???????? ??????? ??? 5-HT1B ??? 5-HT2C ?????????????? ????? ???, ?????? ?????????? AgRP/NPY ??????????? ???? ????, ?????? ????????? ??? ????? ??? ?????????? POMC ??????????? ??????? ??? ??? ????? ?????? ??? ??? ??????????? ?????? ???? ???? ??? ??????????-5-HT ?? ?????? ?????? ????????? ??????? ???? ???????????? ????? ?????????? ??????? ?????? ????

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??????? ?????? ????????? ?????????????? ??? 5-HT ?? ?????????? ?????? ??? ????? ???? ???? ???? ?????????????? ????? ??? ???? GT1-7 ??????? ??????? ???????????? ????? ????????? ?????? ???? ???? ???? GT1-7 ????????? 10μM ????????????? (CORT) ????? 24 ????? ??? ???????? ??????? ????????? ?????? ?? CORT ????????? ??????? AgRP ??? OX1R ?? ??? ?????? ?????????? ????? ?????? ??????????????? ?????? ???????, ?????? MC4R, 5-HT1B ??? 5-HT2C ?? ??? ?????? ?????? ????? ?????? ????? ???????? 0.1μM 5-HT ????? 2 ????? ??? ???????????????? ???, CORt-???????? AgRP ??? ???????? ????? ?????????? ?????? ??????????????? ?????? ??? ???? ??? MC4R, 5-HT1B ??? 5-HT2C ?? ?????? ?????????? ??? ???? ????? ??? ?????????????? ??????? ??? 5-HT ?? ?????? ?????????? ???????? ??? ??????? ??????

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???????????? ??????? ??????? ?????????????? ????? ????? ??? ?????? ????????????? ??? ?????????? ???????????????? ??????: ????????????????????? ???????? ????????? ?? ???????????? ??????? ?????? ???????????????? ARC ?????? c-fos ??? AgRP ?? ?????? ??????????????? ?????? ???????, ?????? LEPR ?? ?????? ??????????????? ????? ??????? (P

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