??????? ???, ?? ???????? ????? ??????, ???? ??-???????? ??????? ?? ????? ??????? ???????????? ????????????? ????? ??????? ???? ???????? ???????? ???? ???? ?? ??????? ??? ?????? ????? ????? ???????????? ???????? ???, ?????? ????? ??????? ??????? ??? ??? ???? ????????? ?????????????????? ??????? ?????

??-??????????? ?????? ????? ????? (NAFLD), ???? ???????????? ????? ????? ???????? ????? ???? ?? ?????? ???? ???? ??????, ??? ????? ??-??% ???? ????????? ??-??????????? ???????????????? (NASH) ?? ????? ???, ?? ???? ?????? ??? ????? ????? ????? ?????? ???????? ???, ???????? ???????????? ???? ????? NASH ????? ?????? ??? ??? ??????? ??? ????? ??????????? ??? ?????? ????? ??? ?????? ????? ???? ?????

????????, ??? ?????-??? ???????????????? ????? ?? ?????? ?????? ??????? JAMA ?????????? ???? ???????? "????????? ???????? ????? ??? ??-??????????? ?????????? ????? ?????????? ?????? ????? ?????" ?????? ???? ?????????? ?????? ???????

???????? ???? ???? ?? ??????? B3 ?? ??????? ?????, ???? ??-??????????? ?????? ????? ???? ???????? ??????? ???????? ???????? ??????? ????? ?????, ????????? ????????? ??????????????? (≤18.4mg/???) ??????? ???????? ????????? ??????????????? (≥26.7mg/???) ???????? ??????? ????? 30% ??????? ???? ????? ????

?? ????????, ??????? ?????? ????????? ? ?????? ??????? ???? (NHANES) ?? ??????? ???? ?? ??? ????? ?,??? ?? NAFLD ????? ????????????? ??????? B3 ????? ?????? ??? ??-??????????? ?????? ????? ???? ???????? ??????? ????????????? ??????? B3 ????? ??? ???????? ??????? ?????? ????? ??????? ???????? ???????

??????? ??? ??????? ??? ?????? ??? ??????????????? ????? ?????? ??? ??? ???????: ?? ????????? ????? (≤??.? ?????????/???), ?????? ????????? ????? (??.?-??.? ?????????/???) ??? ???? ????????? ????? (≥??.? ?????????/???)?
?.? ????? ??? ???-?? ?????? ?????, ??? ??? ?? ???? ?????, ??? ????? ??? ?? ???????? ????? ???? ??????

????????? ???? ???? ??, ??????? ???? ??????? ??????????? ??????????????? ????????? ??????????? ??????????????? ??????? ???????? ??????? ????? ?? ????? ?? ????

??????, ???????? ????????? ??????????????? ?????????? ??????? ????? ?? ????? ????? ???????, ??? ??? ???????????????? ???????????? ??? ???

??? ????????? ??????? ??? ????? ??? ?????????? ??? ???????? ??????? ?????? ????? ???? ??????????? ???????????? ?????? ????, ??? ??? ?????????? ??????? ??????? ?-?????????? ??????? ????????? ???? ????? ????????

???????? ???, ???????? ?? NAD ?????????? ?????? ????????? ??? ??????? ??? ???????? ? ???????? ???? ??? ???? ???????????? ????????????? ????? ??????? ????????? ??????????? ???????? ??? ???? ???? ?? ???????? ?????? ??????? ?????? ???? ???? ??? ??????? ?????? ?????? ????? ????? ??????????????? ????????, ???????? ??????? ????????? ??? ???????? ???? ???? ??? ?????? ??? ??? ?????????? ???????? ???? ?? ?????????? ?????????? ??????? ????? ???, ????????????????? ??????????????????? 2 ??? NADPH ???????? ??????????? ???? ???? ??? ???????? ???????? ?????????? ?????? ????? ??? ????

????????, ???? ????? ???????????, ??? ?????-??? ???????????????? ????? ?? ?????? ?????? ??????? ?????????????? ???????? "????????? ???????? ????? ??? ??-??????????? ?????? ????? ??????? ????? ???????: NHANES 2003-2018" ?????? ???? ?????????? ?????? ?????????

???????? ???? ???? ?? ??????? ??? ??????? ????? ??-??????????? ?????? ????? ????? ????? ?????? ???? ????????? ???, ????? ???????? ??????? ???? ????? ??? (≥??.? ?????????/???) ????? ???????? ??????? ?? ????????? (≤??.? ?????????/???)??? ??????? ??-??????????? ?????? ????? ????? ????? ??% ???

?????? ???? ????, ????????? ?????? ???? ?? ??????? B3 ??????? ????? ??-??????????? ?????? ????? ????? ????? ????? ??? ??-??????????? ?????? ????? ???? ???????? ??????? ???????? ??????? ????? ????? ???? NAFLD ??????? ???????? ??????? ????? ????? ??????? B3 ?? ????????? ??? ??????? ???? ???? ??? ?????? ?????????