??????????? ????? ????? (ALD), ?? ???????????? ???????? ????????? ??? ????? ???? ????? ???, ???? ?????? ????? ???????? ????? ????, ??? ????? ?????? ??????????? ?????? ?????, ??????????? ??????????, ??????????? ????? ?????????? ??? ??????????? ???????? ?????????? ?????????, ???? ??????????? ????? ????? ?????? ??????????? ??????? ??????????

? ?????, ???? ??????, ???????? ???????????????? ??? ???????, ????? ??????? ???????????????? ????? ?????, ????? ??????? ? ????????? ???????????????? ????? ?? ??? ???????? ??????? ??? ????? ??????? ???????? "????????????? ?????????????????? ??? ??????? ??????????? ?????????????" ???????? "????????? ?????? ??????????? ??????? ?????? ??????? ??? ???" ???????? ???? ?????? ?????? ?????

???????? ????????????? ?????? ?????? ???? ????? ??????? ????? B. accidifaciens ?? ????????? ?????? ??? ??? ?????????-???????? ??????? ???? ????? ???? ?????

????????????? ??? ????, B.accifaciens ????? ???????? ????????????? ?????? (BSH) ?? ??????? ????? ??????? ????? ?????????? ???? ?????????? ????? ????????? ?????? ??????? FXR-FGF15 ???? ??????? ???, ???????? ???? ??????? ????? ???, ???????????????? ???????? ???????????????????? (OAT) ?? ???????? ??????? ??? ??? ?????? ?????? ??? ???? ?????????? ?????????? ??????? ??????? ???? ??????? ??????????????? ???? ???????? ?????? ??? ??? ??????? ????? ????? ??????

?? ????????, ??????? ?????? ???? ??????? ????? ??????????? ??????? ??? ??????? ???? ??? ???????? ??? ????????? ???? ???????? ??????? ??????? ??? ??????? ??????????? ??????? ????? ??? ????????????? ???????? ?????? ???????? ?????

?????? ???? ???? ?? ???????? ????????????? ?????? ??????? ??????? ??????????? ??????? ????? ??????????????? ?????? ?????, ??? ????? ?????? ????? ????????? ????? ??? ??? ????? ???????????? ????? ??? ??? ?????? ????? ???, ???? ????????? ????????????? ???????? ??????????? ?????? ??? ???

?????? ????????????? ?????? ???????? ???????????????? ??????????????? ???????? ???? ????, ??? ??????? ??? ???????? ?????? ?? ??????????? ????? ????? ?????? ?????????????? ??????????? ?????? ??????? ???????? ??????????????? ???? ????? ?????

????????????? ??, ???? ???? ?? ???????? ???????? ????????????? ?????? ????????? ??? ????? ?????????? ???????????????????? (ALT) ??? ???????????? ???????????????????? (AST) ?? ?????? ?????, ??? ???? ????? ????????? ??? ???????? ?????? ?????, ?? ?????? ???? ?? ???????? ????????????? ?????? ???????? ?????????????? ??? ???????? ??? ALD ?? ??????? ???????? ???? ?????

???????? ???? ???? ?? ???????? ????????????? ?????? ??????????? ????? ????? ???? ????? ????? ????? ?????????, ????? ????????? ??? ???????? ?????? ????? ??? ????? ???????????? ?????? ??? ?????????? ???????? ????? ?????, ?? ??????????? ????? ??? ???????? ? ????????? ???????? ????????????? ???????? ???????????? ?????? ???? ??????

??? ??? ???? ???????????? ?? ???????????????? ??????? ???????? ??-?? ????? ?? ??? ???? ????????????? ?????? ??????? ??????? ?????? ???, ?????? ???????? ????? ????????????? ??????? ???? ???? ??? ???? ????, ?? ??? ??????? ????????????? ???????? ?????? ??? ??? ???????? ??????????? ???????????????????? ?????? ???? ?????

????????, ????????? ?????? ???? ?? ???????? ????????????? ?????? ?????? ???? ????? ??????? ?????????? ?????????-???????? ??????? ?????? ?????? ???? ???? ??? ???????? ????? ??????? ????? ???? ????? ?? ??????? ????????? ????????? ????? ??? ??????? ??????? ???????

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