???????? ????? ??????? ?????? ?????????????? ????? ????, ????????? ????????? (????) ???? ???? ?????? ???, ???????? ?????? ?? ????? ???? ???? ?????? ?????? ????????? ???? ???? ?? ?????? ????????? ?????????? ????? ??? ????? ??? ?????, ????????? ????????? ????? ???? ???? ???? ???? ?? ????? ?????? ??????? ?????????? ?? ????? ????? ?????? ???

?????? ???????, ??????? "????? ??? ???????, ?????????????? ??? ???????" ?? ??? ?????? ???, ?? "????????????" ???????? ???? ????? ?????? ??????? ????????? ????????? ???? ???????????? ????????? ???? ??? ????? ???????? ???????? ??????????? ???????? ??? ????????????? ??? ??????? ????????? ?????? ????? ??? ????, ????? ??? ????????? ??????????? ??????? ??????????? ???????? ???? ???? ??? ??????? ????????? ????? ???? ?????

???? ???????, ???? ??????, ????? ??????? ?????? ??????????? ??????? ????? ??????????? ?? ????? ??????????? ???????? ??????? ????????? ???????? ???: "????????? ????-?????????? ?????? ??? ? ??????? ?? ??????????? ???????? ???? ?-????? ???????? ?????" ???????????

???????? ???? ???? ?? ???? ????-?????????? ???????, ???????? (??????? K3), ????????? ??????????? ??????? ??? ???? ????? ???????? ?? ??????? K ?? ???? ??-???????? ?????????, ?? ??????? ???? ????????? ?????? ???? ??? ?? ????????????? ??? ???? ???? ?????? ????? ??? ?????? ?????????????? ???????? ????

???????? ???????? ???? ???? ?? VPS34 ?? ?????????????????? 3-????? (PI3K) ?? ???? ??? ???????????, ???????? VPS34 ?? ??????????? ???? ???? ????, PI3P ?? ?????? ????? ???? ??? ?????????? ??????? ?????? ???? ???? ?? ????????? ????????? ????? ??????? ???? ???????? ???? ???????, ????????? ??????? ???? ???? ?????? ???? ??? ??? ?? ????? ???? ???? ???? ???????? ?????? ???? ????? ???????, ?????? ???? ????????? ?? X-?????? ????????????? ??????????? (XLMTM) ???? ???? ???????? ??????? ????????? ?????????? ???? ?????????? ?????? ???????

?? ????????????? ?????????? ????????? ???? ???? ??? ?????? ??????? ????? ?????? ??? ??? ?????? ??????????? ???????? ????? ????? ???????? ??????? ????? ???????? ???? ???? ?????? ?????

???? RapidCaP ???? ??????? ???? ????-?????????? ???????, ???????? ???????? ??????? (MSB) ????? ??????? ?????, ?? ???? ??????????? ??? ?? ??????? K ?? ?????????? ???? ?????? ?? ?????? ??? MSB ?? ????? ??????? ????????? ??????????? ??????? ??? ???? ???? ??? ???? ???????????? ???????????? ?????? ???? ???? ?????

????????????, ???????? ???????? ?? ??????? ??? ????? ??, MSB-?? ??????? ?????? ???????????? ????-?????????? ??????????? ??? ???? ????????? ??????????? ????? ??????? ??????????? ???????? ??? ????? ???? MSB PI3K ?????? VPS34-?? ??????????? ???? ???? ????, PI3P-?? ?????? ????? ???? ??? ?????????? ??????? ??????? ????, ??? ??? ????????? ????????? ????? ?????? ???? ???????, X-?????? ????????????? ???????????? (XLMTM) MSB VPS34-?? ?????? ??????????? ???? ???? ????, PI3P-?? ????? ??????? ?????? ???? ???? ??? ????? ?????????? ???? ?????