?????????????????? ??? ????????? ???????? ???? ????????? (???????? ?-???????? ?????, ??????-?????) ?????????? ?? ??????? ????? ????? ?????? ??? ?????????????? ??????? ???? ???? ??? [1]? ????????? ??????? ?????, ????? ????-??????? ?????? ???? ???? ???, ??? ??? ??? ?????? ?? ????????? ????????????? ??????? ???? ?????????? ??????, ?????????? ????? ??????? ?????? ??????? ???? ???? "??????????" ??? ????? ??????? ?????? ???? "??????-?????" ???? ????????? ??? [2]? ????? ??????? ???, ??? ???? ??? ?????? ???: ???????? ??? ?????? ????-?????????? ???? ??????? ???? ???, ?????????? ????????? ????????? ??? ???????? ????????? ???? ???? ????? ??????? ??? [3]? ??????????????? ?????????? ????? ????? ????? ??????????????? ??? ???????? ??????????????????? ?????? ???? ???? ??????????? ??? ???? ?????? ???? ?????????? ???? ????, ??????????? ?????? ??????? ??????? ???? ?????? ??? ?? ??????? ???????????? ????? ???? [4,5,3]?

?????? ??? ??? ???

????????? ????????????????? ??? ??? ??????? ???????? ?????? ?????? ???? ??????????????? ??????, ??? ????????? ????????????? ??? ??????? ?????? ??? [4,6]? ??? ?????????? ???? ???????? ?????? ???? ???? ??? ????????????????? ??? ????? ??????? ???????? ???? ???? [4,5,2]? ?????? ??????? ???????? ?????? ????????????????? ??? ??????????????? ????? ???, ?? ?????? ???? ???? ?????????????? ??????? ?????? ???? ???? ????????? ????????? ?????? ????????? A2??? ???? ???? ??? ?????? ?????????????????? ????????????? ????? ??? [7,8]? ????????, ????????? ??????????????????????? ???????? ????? ???? ??? ??????????????? ???? ??? ????-????????? ????? ???? ????? ??? ??? ??? [9,10,1]?

????????????? ???

???? ???????? ??? ????? ???? ????????? ???????? ???? ??????? ??????? ??????????? ?????? ??????? ????????? ????? ?? ???????? ????? ??? ????? ??? ?? ????? ?????? ???? ????? ?????? ??????? ????? ?????? [11,12] : ?????? ??? (?????) ??? ?????? ??? ???? ???? ???????? ?? ???? RNA ???????????? ?? ????? (????? ??? ?????? ????) ??????? ???? ?????? ???; ??? ????????????? ?????? ???? [13,14]? ????????? ??????? (???????, ????????) ???????? ??????? ?????? ???????? ???, ?? ????????: ????? ????-?????? ????????????????? ???????

??????????? ????????? ???????? ??? ??? ????

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????-????????? ???????? ??? ????????? ???? ???????? ??? ??????? ????? ?? ???????? ????? ?????? ???? ???? ???????? ?????? ????? ???? ????? ???? ????????? ?????????? ???????????? ?? ?????????? ????? ?????? ?? ??????-????? ????? ???? ?????? ???????? ????????????????? ??????? ??????????? ??? ???? ????? ???? ????, ??? ????? ?????????? ??????? ?????? [9]? ?,??? ????? ???? ?????? ????? ?????? ????????, ????????? ??????? ??????? ??, ??% ????? ??????????? ?????? ?????? ???? ???? ??? ??% ????? ??????????? ????? ???? ?? ???????? ???????? ???????????? ???? ???, ??? ?????? ??????????? ?? ???? ????? ?????? ???? [18]? ????????? (? ????? ???? ???? ?????????) ????? ???????? ????????????????? ??? ?? ?????? ????? ???????? ?????? ??? ???? ??? [19] ????? ???: ?????????? ????? ???????? ???? ???? ?????????????? ??? ????????? ?????? ?????? ???? ???? ??????? ???????? ????????? ???? ?????????? ??? ?????? ???????? ??????? ?? ??? ?? ????? ????? ????????, ??????-????? ???????????, ????????????? ??? ??? ???? ????? ???? ??????????? ?????? (???? ?????????) ?? ???? ???, ??? ?????? ?? ???? ??? [??,??,??]? ?????? ??????????? ????? ????, ??????????? ????? ???? ??? ???????? ??????? ??? ???? ????????? ??????? ????? ???? ??? ??????? ????? ?????? ?? ?????? ???????? ?? ???... ??? ?? ????? ??????????????? ??? ???? ????????? ?????????, ????????? (???-??? ?????????) ?????? ??? ?????? ???????? ????? ????? [??,??]? ???????? ??? ?????? ????? (??? ?????????) ???????? ???? ?????? ?? ?? ?????????????? ???????? ?????????? ????? ????? ??? ????????????? ???? ????????? ???????? ???? ?????? ??????? ??? ??? ?????? ????? ????? ???? [??]? ?? ?? ????? ??????????????? ?????, ??????????? ???? ?????? (??? ?? ???? ?????????) ??????? ???????? ????? ????? ????? - ????????????? ???, ??? ??? ????? ??????, ???????? ??????????? - ??? ????????? ????? ???????? ?????? ?? [??] ????? ????????? ??? ????????, ??????????? ????????? ???????????? ??? ???? ?????? ?????? ??? ???? ???????????? ???????? ???????? ??????? ??????? ?????????? ?????? [??] ?????? ????????? ???????? ???????? ?????? ??? ???????? ?? ?? ???????????? ????? ???????? ???????? ??? ??? ???? ???????? ???? ???? ?? ????????? (? ?????? ??? ???????? ?,??? ?????????) ????????? ???????????? ????? ??? ??? ???????? ?????????? ????? ???? ??? ???????????? ?????? ????? ???? ?????????? ??? ??????? ??????? ???????? ?? ??????????? ?????? ????? ??? ???? ???????? ???? ??????? ???? ???? [27,28]? ???????? ?????? ???????, ????????? ?????? ??? ?????? ???????? ?????? ???? ????, ????? ??? ?????? ???????? ?????? ??????? ?????????? ?????????

?) ??????? ?????????

?????????? ???? ????????? ?????? ???? ???????? ???? ???? ????? ???? ???? ???? ??? ?????????? ???????? ????? ??? ????? ????????? ??????? ?????? ????????? ??? ??? ????? ???????????? ?????? ???? ??? ??????? ???? ???? [29,30]? ????? ????????? ?????????? (1,300 ????? ???? ????) ???? ????-???????? ???????, ????????? 24 ?????? ????? 2000 ????????? ????????? ????? ???? ???????? ?????? ????? ???????? 38% ?????? ???? [10]? 4,000 ????? ???? ??????? ???? ????? ?????? ?????????? ???? ?????? ?? ????????? ????? ??? ???? ???????????? ?????? ???; ???? ?????? (2000-4000 ?????????) ??? ???????? ?? ???????? ???? ???????? ?????????? ??? ??, ??? ???? ????????? ????????? ?????? ?????? [31]? 3,000 ????? ???? ????? ??? ???? ???????? ????? ????????? ???? CDP-??????? ???? ??????????? ?????? ?????? ?????? [32,33]? ????? ????????? ???? ???? ????? ????? ????? ?????? ???? ???????? ?????????? ???? ?? ?????????? ????? ?????? ?? ????????? ???????? ?????? ?????? ???? ???? ???? ???? ????? ??????? ??????? ????? ???? ????? ????? ??????? ???? ???? [34,35]? ??????????? ?????? ??????? ??????? ???????????? ?????? ???? ????, ??? ?????? ?????? ????? ????????? ???? ???? ?????? ????? ????? ????? ??????

?) ?????? ??????

???????? ??? ?????????? ??????? ????? ???? ???, ????????? ????? ???????? ??? ??? ?????? ?????? ????? ????? ??? ??????? ??????? ????? ?????? ???? ???? ??? ????? ??? ???? [1]: ????? ??????????? ???????? ??????????????? ???????? ?????? ????? ??? ??? ???????? ???????? ????? ???????? ????? ???? ???? ??? ???????? ??? ????, ?? ???? ???? ???????? ????????? ???? ???????? ??? [36]? 80 ?? ???????? ????? ??? ???? ????????? ?????????, ???????????? ????? ????????? ???????? ????? ?????? ???, ?????? ????? ??? ??? ????? ??????? ??? ??? ???? [37,38]? ????????? ?? ???????? ??? ???? ????????? ????????? (68 ?? ????) ??? ????? ????????? [39,40]? ???????????????, ?? "??? ???", ??? ??? ??? ??? ??? ???????? ??????? ??????? ??? ??? ??? ???? ???? ????? ?????? ???? ???? ????? [41] 190 ?? ????? ??? ????? ????????? ?????????, ???? ????????? ????????????? ??????????????? ??????? (????? ?????) ????? ????? [42,43,44]? ?????? ????? (???????? ???? ?????????) ??????? ???????????????? ???????? ?? ?? ??????????????? ????? ??????? ??????? ????? ??? ??????????? ????? ?????? ???????? ?????? ???? ??? ??? ??? ???????? ???????????? ???? ???, ??? ????? ????????? [45]? ????? ??????????? ????? ??????????? ?? ???? ????? ????? ???????? ???? ?? ????????????? ??????? ????? ????? ????? ????????????? ???????? ?? ?? ????? ?????, ????????? (? ??? ??? ???? ?????????/???) ???????? ????? ?????? ??? ??????????? ????? ????? [46]? ???????? ?????? ??? ?? ?????? ?? ???? ??????? ???????? ???? ????????? ????????? ??????? ???? ??? ????????? ?????? ???? ?????????? ?????????? ?????? ??????, ???-??????? ??????, ?? ?????????? ????????? ?????????? ???? ?????????? ?? ??? ????? ???? ????? ???, ????? ??????? ???? ????????? ??????? ?????????? ?????? ???????? ??? ???? ????

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?????????? ???????, ???????? ???????????? ??? ???????? ??????? ?????? ?????????? ????? ???????? ?????? ???? ??? ????? ?????????? ????? ???????? ???? ????? ??? ??? ???????????? ??????????????????????? ????? ??? ???????? ??? ?????????? ?? ??? ???? ????? ???? ???????? ??? ????? ????????? ?????????, ????????? (?-? ??? ??? ???????? ???? ?????????) ???????? ????? ??????????? ????? ????? [??,??,??]: ????? ?????? ?????????? ????????? ???? ?????????? ???????? ????? ????????? ???? (????????? ??? IL1B) ?????? ????? ?????? ??????, ???? ???????? ???????? ???????????? ???? ??????? ??????????? ??? ??????? ?????? ????????, ???????? ????? ????? ??????? (APOE-e4 ????) ??????? ??? ???? ?????? ??????? ??? ???? ???????????? ???????? ???? APOE-e4 ???? ??????? ??????????? ???? ????????? (??? ???????? ?????) ???????????? ?????? [??,??]? ?????????? ???????? ????? ???? ????? ??????? ?????? ?????????? ??? ???? ?????????????? ???????? (??? ????? ???? ?????) ??????? ??? ????? [??,??]? ???????? ???? ???????? ???????????, ????????? ??????? ??????? ???? ????????? ????? ??? ??? ???? ???????? ?????? ????????, ??????????? ?? ???????? ???????? ??? ??????????? ????? ??? [53]? ????????? ???????? ????? ????????? ??? ???????? ??????? ????? ???? ??????? ???? ????, ??? ???????? ????????? ?????? ??????? ????????? ??? ????????? ???? ??????? ??????? ????? ???? ???? ???? ??????, ????? ??? ???????? ????? ?????? ???? ????????? ???? ???????? ???????????, ????????? ????????? ????????? ?????? ???????? ???? ???? ???? ?????? ???? ?????? ????? ??? ???????? ???????? ??????? ??????? [54,55]? ???????? ??????????? ??????? ??????? ????? ?????? ?????? ????????? ????? ???????? ????????????? ??????? ???? ????, ??? ???? ?????? ??????? ??? ???????? ???????? ???? ????? ???????? ???????????????? ????????? ?????, ?????????? ?????? ?????????? ??? ???? ??????? ???????? ???? ??????????? ???????? ?????????? ?????? [56,57]?

?) ?????? ?????? ??? ??????????

???????? ?? ?? ????? ??? ??? ???? ????????, ???? ??????????????????? (???????????) ?? ???? ????????? ??? ???? ????????? ????? ??? ?????? ????? ?????? ??? [58]? ??????? ????????, ??????-????? ?????????? ??????, ????? ??? ???????? ???????? ?????????????, ??????? ??? ??????????? ?????? ?????? ??? [59,60]? ???????????? ??? ????? ????? ????????? ?? ?? ???????????? (???) ??????? ????? ????????? ????? ????????, ?????? ???? ????????? ??? ??? ?????? ?????? (? ??? ??? ???? ?????????/???)? ?? ?? ???????????? ??????? ??? ?????? ????????, ????????? ?????????? ???????? ????? ??? ?????? ??????? ???????? [61,62]? ???????? ?????????? ???????? ??? ????? ???? ????? ??????? ????????, ????????? (? ??? ??? ???-?,??? ?????????) ?????? ??????? ???????? ?????? ??????? ???????? ?????? ???, ?? ?? ???? ????? ???????????? ??? ??? ???? ?????????, ??? ???? ?????? ?????? [63,64,65]? ????? ???????? ???????????? ???? ???? ?? ????????? ??????????, ????? ??? ??????? ??? ??????? ???????? ?????? ???? ????, ??? ????????? ????????? ???????? ????????????? ???? ????? [66]? ????????? ??????????????? ???????? 66 ?? ????? ???????? ????????????? ???????? ?????? ?????? ?????? ??? ??????? "????????" ????? ???? ?????? ?????????, ?????? ??????? ??? ?????? ????? ???? ??????? ???? ????? ?????? ??????? ??? ????????? ???? [67]? 24 ?? ????? ??????????????? ????????, ??????-????? ????????? ??????????????? ?????????? ???????? ??? ????? ?????? ???, ?? ??????? ??????????????? ?????????? ???? [26]? ???????? ?????????? ??????????, ??? ?????? ?????? ??? ??????????? ????????? ??????????? ??????? ?????? ???? ???? ???????? ?????? ????