???? ????-??????? ?? ?????? ??? ??????? ???? ??????? ???? ???????? ?????????????? ???? ????, ?? ??????? ???? ??? ???????? ??? ???? ?????? ???????? ???? ?? ??? ???????? ?????? ???????? ???? ???? ???? ???? ???????????? ?? ??????? ?????????? ????-??????? [1] ?????? ??????? ????? ????-????????? ?????? ???????? ????? ?????? ???, ??????, ????????? ????? ???????, ???? ???? ????? ????-??????? ???????? ?? ?????? ???? ???? ??, ??? ????? ?????? ??????? ?????? ??????? ???? ????

β-??????? ??? ???? ??? ??????? ?????? ??? ???????? ??????? ??? ???? ??????? ?????? ??????, β-??????? ??? ????????? ????? ????? 30% ???? 60% ?? ???? ?????, ??? ????????? ??????? ?????? ?????, ???????? ??????????????? ????????, ?????? ????????????? ??? ?? ??? ????????? ????????? ????? ????? ????, ???? ??? ????????? ????????????? ????? ????? ????? ?????? ??? ?????????? ??????? ?? ???? β-????????? ??? ???? β-1, 3-???? ?????? ???? ??? ??? β-1, 6-???? ???????????? ???? ????????? ?????? ???????

???? ????-????????? ??????????????? ??????????? ?????? ??? ?? ??????????? ???????????, ??? ????????? ????? ??????? ????????? ?????????? ???? ????? ?????? ??????? ???, ??? ???? ????????????? ?????????????? ????????? ??????? ???? ?? ???????????? ????? ?????? ??? ???????? ???????? ?????? ??? ???? ??? ??? ???????? ????????? ????????? ???????? ????? ?????

????-??????? ???? ????? ????-??????? ???????? ????? [4] ???? ????? ???? ??? ???: (1) ??????-1 ????????; (2) CR3; (3) ????????????? ???????? ??? LacCer ?? ???????? ????????? ??? ???? β-??????? ???????? ?????? ??? ??? ?????????? ???? ????? ???, ??? ??? ?? ??????????? ????? ???????? ???????? ????? (ITAM) ??? ?????? ??????????? ?????? ??? ??? PI3K/Akt ???? ??????? ???, ?? ??? ??????? ??????????????, ????????????? ?????? ??? ????????? ???????? ???? ???????? ???, ???? ?????? ????????? ??? ??????? ??? ?????? ???? ??? ?????? ???????? ?????? ???????? ??? ????? ??? ?????? ???? ??? ???????? ??????? ?????? ????

????-????????? ?????? ??????????? ???????? ??????? ?????????? ????????? ????????? ??? [6] :

?) ?????????????????? ??????: β-????????? ?????????????????? ????????? ??????, ?? ???????????? ??? ???????? ??????????????? ???????? ???????? (ROS) ???????? ???? ???? ???? ??? ????? ?????????? ????????? ????? ????? ?????

?) ?????????????? ??????: ???? ????? ????? ?????, β-????????? ????????? ??-????? ?????? ??????, ?? ??????????? ?????? ????? ??????? ???? ???? ????????? ??????? ???? ????, ???? ????????? ??? ???? ???? ??? ?????????? (TEWL) ?? ??????? ???? ????? ????? ????? ???????, ??? ?????? ?????? ???? ?????????????? ????? ???? ???, ?? ????? ???????? ??? ?????? ????? ????? ??????? ????

?) ???? ?????? ??? ??????? ??????: Seo ??? ?????????? ??????? ?? ????-????????? ??????? ??? ??????? ???????????? (HaCaT) ??? ??????? ?????? ?????????????? (HDFa) ?? ???????????? ??????? ???? ???? ??? ???? ?????????? ???? ???? ??? ??????????????????????? ?????????? ???? ???? [7]? ???????, ????-????????? ??????-?????? ??? ??????-?????? ????????? ?????? ??? ?????? ???? ???? ??? ??????????? ?????? ??????? ???? ??????? ???? ??????? ?? ?????????? ????????????? ???????? ???? ???????? ???? ???? ?? ????-??????? ????? ????????? ???????????? (??????) ?? ???????? ???? ???? ??????? ?????? [8]?

?) ????????-?????? ??????: ????-??????? ?????? ?????????? ?????????, ???? ??????? ??? ???? ???? ????? ??????? ???? ??? ??????? ??? ???????? ?????? ???????? ??????? ??????????? (ECM) ??????????? ?????????? ??????? ???, ?????? ??????? ??? ?????????????? ?????? ????

???????, ????-??????? ???????? ?????? ??????????, ?????????? ?????, ???????? ????????, ?????? ????????? ??????? ????????? ?????? ???? ????

?