?????? ??????: ???????????? ???????? ?? ??????? ???? ??????? ???
?, ????? ??????
?????? ?????????? ?????????? ?????????????
???? ????????? ??????? ?????????? ??? ????????? ?????????? ??????????????? ???????????? ????? ??, ?? ????? ?????????? ????????????? ????? ???? ??? ??, ???????????? ??????????? ???? ???? ?? ??? ????? ??????? DNA ????????? (TET2) ?? ??????????? ???????? ???????????? ???? ???? ???????????? ??? ???????? ??? ??? ??.
??????? ?? TET2 ??????? ??????????? ?????? ??? ??
TET2 ?? ?????? ??????????? ?????, ??????? ??, ????? ???????????? ????? ?? ??????????????? ?????? ????? ????? ??? ??? ??, DNA ?????????? ??????? ??????????? ??? ??? ?? ??? ???????????? ??????? ????????? ????? ??? ??? ??? ??.
???????????? "???? ??????" ?? ??????????? ????????? ????
????????????? ?????? ???????????? ???-???? ??????? ?????? ??? ??, ???????????? ??????? ???? ???? ??????????? ????? ??. ?????????????? ???? ??????? ????? ?????? ? ????????? ????????? ???? ??? ?? ??? ???????????? ????? ????????? ???? ????? ??? ??.
2, ????????? ??????
????? ????? ???????: ???? ??? ????????, ??????? ?? ??? ????????????????? ?????? ????? ??????? ????? 60% ????? ??? ??, ???????? ???????????? ?????? 80% ????? ??? ??, ??? ????? ???????? ??????? 50% ????? ??? ??.
???????????? ???: ??????? ?? ?????????? (IFN) ????????? ??????? ????? ??, ???????????? ????? ???-????????? ???????????? ??? ?????? ???????? ????? ????? ??, ??? STAT1 ????????????????? ?????? ??, ?? ???? ?????? ???????????? ?????????? ?????? ??.
?, ???????? ????????? ????????
??? ?????????? ?????? ??? ????: ? ????????? ?????????? ??? ??????????????? ??????????????? ???? ???-????????? ?????????? ??? ????, ??? ????? ??????? ??? ??? ???? ?????????? ?????????????? ?????? ?????? ????, ???-???????????? ?????? ??? ????? ???? ???? ??.
??? ?????? ?????: ??????? ??, ?? ????? ??? ??? ????? ???? ????? ?????, ????? ?????? ?????? ??? ?????? ?????? ???? ????? ?????????????? ???? ????????? ????? ???? ??.
?????? ???? ?????: ??????? ??????????? (??? ?? ??????? ??) ??? ?????? ???? ???????? ????????????? ?????? ??????? ???? ???????? ???? ?????????????? ???? ?????? ???? ????? ??? ??.
?, ???????? ?????? ?????
???? ????????? ??? ??????????? ???? ???? ?????????????? ???? ??????? ???? ???????????? ???? ??? ??????? ??? ?????????? ??????? ???.
???-????????? ???????????? ??????? ?????????? ?? ????? ?????? ??????? ?? ?????? ?????? ????????? ???.
????????????? ????-TET2 ?????? ?????? ?????? ??? ??????????????? ???? ????????