1. ??????? ????????? ?????????? ?????

HMB ? ?????-????? ???????????? ????? ? ?????? ?????? ????? ?????????? ?????? ?????? ??????? ??? ??:

?

?mTOR ?????? ????????? ?: ???????? S6 ?????? ????????????? ??????? 38% ?????, ??????? ???? ???? ??? ???? ??? ??????? ???????? ?????????????? ????? ?

? ???????????????? ?????? ??? ?: E3 ??????????? ????? MuRF1 ?? ????????????? 41% ????? ???, ??? ?????? ??????? ?????????? ?????? ??????????? ??????? ???.

? ??????? ????????????? ? : ????? ????????? ????? ?????? ??????? ??????? ????? ???? LC3-II/LC3-I ?????????? 1:1.5 ???? ????????? ???.

?????, ??? ??? ??????? ????????? ??????

HMB ??????-?????? ?????????? ?????? ??? ??????? ????? ??:

?

? ??? ?????? ????? ??????? ?: ????????????????????? ?????????? 27% ?????, ?????? ????? ???????? ??? ???? ??????????? ??????.

? ???????? ??? ????? ?: ?????????????? ?????????? ??????? ???????? ???????? ???????? ?????? ?? ??? ???????? ????????? ???? 63% ????? ??.

? ?????????? ???? ????? ? : ?????? Nrf2 ?????, ??????????? ?????????? (SOD) ?? ???????????? 41% ?? ????? ???.

III. ???????? ????? ?????????? ????

1.???? ??????? ???? ?????

?????? ???????? 3 ?????/???? HMB ???? ?????? ??? ????????? ?????? (CK) 44% ?????? ??? ?????????? ???????? ??????? 51% ?????.

72 ?????? ????????????? ???? ???, ?????? ??????? Z-???? ????????? ???????? 62% ????? ??? ???, ??? ???????????????? ???????? ??????????? 83% ?????? ??? ???.

2. ???????? ??????? ????????????

??????? ??????????, ??????? ?????????? ???? 19% ?????? ??? ?????? ?????????? ???????? 27% ?? ????? ???.

6-?????????? ???? ????? VO2max ??? 4.2% ?? ????? ????? ??? ?????? ??????????? 13% ?? ????? ?????.

?.???????? ??????????????? ????????????

?. ?????????? ????? ?????????? ?????? ??? ??????

28 ???? ???? HMB ???? ???? ICU ?????????, ????????????? ???????? ????? 1.3mm ??? ????? ???????? ??? ???, ??? ?????????? ??-?????? ????? ?? 31% ????? ???.

????? ???? ???? ????? ?????????, ??????? ????? ?? 47% ??? ??? ??? ?? ??????? ??? 5 ???? ??? ???.

2. ????????????? ??????????????? ?????????

?? ?????????? ????????? ???, ?? ?????? ??? ?????? ???????? ??????? ??? ?.?? ????/?????? ???, ??? ??? ?????? ???? ??% ??????.

??????? ???????????????? ???? ??????????? 21% ????? ??? ?????? II ?????? ????? ?????????? 14% ????? ?????????.

?.?????????? ??????????? ??????

???? ??????? ??????

??????? ??????????????? ?????????? ?????? ?????? ??????????? 3.7 ??? ????? ?????, ??? ?????? ?????????? ???? ?? 7% ?? ??? ???.

??????? ???????????? ??? EMG ???????? ????? ??????? ??? ?? ??? ????? ??????? 15 ?????? ???? ????? ??.

??????? ????????????? ??????

??????????? ??????? ????? 8.7 ?????/???? ???? ????????? ??? ??? ??? ??????? ??????? 62%?? ????? ??? ???.

CRISPR ??????? ????????? ????????? ????????? 41% ??? ??? ??, ???????????? ??????????? ?????? ??? ??.

?. ?????? ???????????

? ????? ?????? ? : ???????? ????? LD50 > 5000mg/kg, ????????? ???-???? ?? ?

? ????? ?????? ????? ? : 12 ??????? ????????? ??? ??? ?????????? ???? ??? ???? ??? ? ???, ??? ?????????? ???????? ????? 3% ?? ??? ???.

? ??? ?????????? ?: ???? ???? ??????? ??????? ?????? 3 ?????/???? ?????? ????? ??????? ??? ??, ????????? ?????? ????? ?????? ????????? ??? ??.

??. ????????? ??????

?????????? ????? ?: ?????? ????? ??????? ????? ???????? ?????? ?? HMB ?? ??????? ??????? ????? ?

? ?????????? ???????? ??????????????????? ?????? ?: ???????? ????????????/???????????? ???????? ?? HMB ?????????????? ????????? ????????? ???????? ?