??????? E ?? ????? ?????? ??? ????????? ?????? ???????????? ?????? ?????? ??????? ??? ??, ??? ?????? ?????? ???? ???? ??:

1. ????? ????????? ??????? ?????? ??
??????? E ???????????????? ???? ????? ??, ????? ?????? ??????? A20 ?? ?????? ??? ??, NF - κ B ????????? ??????? TNF - α - ??????? ??????????? ?????? ??, ?????? NF - κ B ????????? ?????????? ??????? ?? ??? ????? ?????????? ??????? ??? ??? ??.
NF - κ B ? ?? ????? ??????????????? ????? ?? ?? ????? ?????? ????????????? ????????? ??? ??, ??? ???? ??????????? ????????? ????? ???????????? ??????? ????? ???? ??.
2. ????? ???????? ????? ??? ??? ?????????? ???? ??? ???
??????? E ?????? ???? ?????????? ????-??????? ????? ??????????? ?????? ??, ????? ???????? ??? ??? ?? ??? ?????????? ?????? ????? ??? ????? ???????? ????? ??.
3. ????? ??????????? ????????? ????? ??????
????????????? ??? ????????? ???? ????? ???? ?????? ????? ?????? ??? ???????????? ????????? ?????? ??, ??? ??????? ??????? ????? ??????????? ????? ??.
????? ???????????? ???????? (??? ?? ?????????????????) ??? ??????? ??????? ??? ????? ?????? ??????? ??????????????? ????? ?????????? ??????.
4. ???????????? ??? ???????? ?????
???????????? ?????? ????? ?????? ???????????? ?????, ??? ?? ????? ?????? ?? ??? ?? ?????? ????????, ??? ???????????? ??????????? ??????? ????.
???????????? ?????? ??? ??????? ???????? ???, ?????? ??????? ????? ????? ???? ??? ?????????? ????? ?????????????? ??????.
????? ?????? ?????? ?????? ??????
??????? ?????: ?????????????? ??????????? ???? ????? ?????????? ????? ??????? ????? ??? ???? ??? ??? ??, ?????????? ??????????? ?????? ?? ??? ?????????????? ???? ????? ??.
??????? ???? ???: ?? ??????, ??????????????? ??? ????? ??????? ???? ??????? ????? ???????? ??? ??????? ??? ??? ??? ??.