???? ??? ????? ??? ?? ????? ?????? ?????? ??????? ??? ?????? ????????? ????????? ?????? ?? ??? ??, ??? ?? ?????, ????? ??? ???? ????????? ??????, ???? ??? ???????, ??? ??????? ??? ???? ?????? ???????. ?????? ????? ???? ??? ???? ????????? ???? (????????? ????) ??????? ??, ???? ??, ?????? ????? ??? ????????? ???????? ??? ???? ???? ??? ????? ??????. ????????? ???? ?????? ??????? ????? ???? ??? ??, ?? ??????? ?????? ????? ???????????? ?? ??. ??, ???? ??? ?????????? ???? ??? ?? ?? ?????? ??? ??? ?????????? ?????? ??? ????-??????? ????????? ???? ????? ??? ????? ??? ? ????????? ???? ????, ???????? ??????? ????????? ?????? ??? ??? ??.

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?????????? ? ???? ??????? ?????? ????? ?????????? ?? ?? ??? ?????? ????????????????? 5-????????????????????? (5-HT, ???? ????????? ????? ?? ???????? ??? ??) ??? ???????? ??. ???? ????????? ???????? ?????????? ?? ?? ?????????? ?????? ??????? ????? ?????? ???? ???? ??? ???? ??????? ??, ??? ?? ????????, ?????, ?????????????? ?????. ?? ? ????, ?????????? ??? ???? ?????????? 5-HT ??? ??? ????? ???????? ???????? ?? ????? ??. ??, ??????? ?????? ?????????, ??? ?????????? ?????? ????? ??? ??? ? ?????? ???????? ????-??????? ?????? ????? ???? ??????? ??? ? ????????? ???????? ??????, ???????? ??????? ????????? ?????? ??? ???.

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???????, ???????? ??????? ????? ??????? ???????-??????? ?????? ????? ????? (CMS) ???????? ???? ?????. ???????? ??????? ???, ????? ??????? ?????? ???? ???? ???? ??????? ??? 21 ???? ???? ????? ???????? ???? ???????? ????, ??? ?? ??? ????, ????????? ???????? ??? ???? ?????? ??????? ????? ???? ?????. ??????? ??????? ?? ?? 21 ?????? ??????? ???? ???, ?????? ????????? ????? ??? ????? ????? ????? ??????????. ?????? ????? ?????? (OFT) ???, CMS ????? ??????? ?????? ??????? ???? ?????????? ??????? ??? ????????? ???? ??? ??????? ????? ???, ?? ??????? ?? ?? ????? ???????? ???? ?????? ????. ?????? ????????? ?????? (TST) ???, CMS ????? ??????? ???????? ??? ????????? ???? ??? ??????? ????? ???, ?? ???????? ???????? ????? ????? ??. ?? ? ????, CMS ????? ??????? ??????? ??????? ????????? ????? ??? ???, ????? ?????? ????????? ????? ??? ???, ?? ????? ?? ?? ????? ??? ??? ????????? ???? ?????? ???.

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????????, ???????? ?????? ??????? ??????????? ????????? ???????? ?????? ????????? ???????? ??????. ??????? ??????? ?? ?? CMS ????? ??????? ???? ?????????????? ?????? ????????? ???? ?????? ????, ?????? ??????????? ???????????? 5-??????????????????????? (5-HT) ??? ???????????????? ?????? ????????? ???? ?????? ????. ??? ???????? ??????? ?? ?? 5-????????????????????????? ??????????? ????? ???????, tph1 ?? mRNA ??????????, CMS ????? ??????? ????? ???????? ????????? ???? ????-??????????? ???, ??? ???????? 5-HT ?? ?????????? ?? ????? ???? ????? ???. ? ????? ?? ?? ??????? ???? ??????? ???????? ???????? ???????????-5-HT ????????? ??????? ??????????????? ????????? ??? ??, ???? ??????? ???????? 5-HT ??????? ??????? ??? ??.

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???? ??????????? ???? ????-??? ??????? ??? ??? ????? ???, ????? ?????????? 5-HT ???????? ????? ????????? ????????????????? ????? ?????????? ?????? ???? ?? ??? ???, ???????? ??? ???? ???? ??? ??????? ???????????? ????????? ??????? ????? ??. ???????? ?????????????? ??? ???????? ????? ??? ???????????????? ??? 5-HT ???????????? ????????????? ?????????? ??? ???????? ??????. ??????? ??????? ?? ?? ??????? ???????? AgRP ??? OX1R ???? ????? ?????????? ???? ?????????????????? ????????????? ????????? ????? ????? ??, ?????? LEPR, MC4R ??? 5-HT1B ???? ????? ?????? ???????? ????????????? ????? ????? ??. ? ????? ?? ?? ???????????-5-HT ??????? ???? ???????????? ?????? ???????? ??? ????? ???????? ????? ????? ??? ???? ??? ??.

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??, ??? ?????????? ???? ???? ?????? ??????? ???????-??????? ??? ??? ?????? ????????? ?????????????? ???? ??? ??? ??? ???????????? ?? ??? (100mg/kg ??? 300mg/kg) CMS ??????? 21 ???? ???? ????? ????? ?????? ??????? ????? ???. ??????? ??????? ?? ?? ???????????? ???? ??? (300mg/kg) ???? 21 ?????? ????????? ???, ?????? ????? ?????? ??? ?????? ????????? ????????? ??????? ????? ??? ????? ???? ?????????? ????????? ?????? ??? ???, ??? ???????? ???? ????? ??????? ??? ??? ????????? ????????? ????. ??? ???????? ?????????? ?? ?? ????-??? ?????????? ????????? ??????? ??????? ?????? ??????? ?????????????? AgRP ??? OX1R ???? ????? ???????? ???? ???????? ??????? ?????? ??? ??, ?????? LEPR, MC4R, 5-HT1B ??? 5-HT2C ???? ????? ?????? ???????? ???????????? ??????????? ??? ??? ??. ? ??????? ????? ?? ?? ?????????? (100 ?????????/????) ????? ??? ????? ????????? ??????????? ????????? ?????? ???? ????? ? ???, ??? ???? ?????? ????? ???????????? ??? ??????? ???? ????????????? ?????????? ??? ???? ?????? ????.

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??? ?????????? ???????? ???????? ?????????? ?? ?? 5-HT, ???????????? POMC, AgRP ??? ???? ???????? ?? 5-HT1B ??? 5-HT2C ???????????? ???????, ????? ?????????? ???? AgRP/NPY ?????????? ?????? ??, ????? ??????? ??? ????? ??????? ?????????? ???? POMC ?????????? ?????? ??? ??, ??? ??? ??? ??? ????? ????????? ??????? ?????? ???? ??. ? ??????????-5-HT ????? ?????? ????????? ??????? ??????? ???? ?????????? ?????????? ???????? ?????? ???? ???? ??.

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???????? ??? ??????? ???????????????? ?? 5-HT ?? ????????? ????? ??? ?????? ???? ???? ???????????? ??????? ??? ???? GT1-7 ?? ?? ????? ?????. ???? ??????? ??????? ????????????? ?????? ???? ???? 24 ???? ???? GT1-7 ?????? 10μM ??????????????? (CORT) ???? ?????? ???. ??????? ??????? ?? ?? CORT ?????? ?????? AgRP ??? OX1R ???? ??? ??????? ??????? ?????????? ????????? ???? ???-?????? ??????? ??? ???, ?????? MC4R, 5-HT1B ??? 5-HT2C ???? ??? ?????? ??????? ?????????? ???-?????? ??????? ??? ???. 0.1μM 5-HT ???? 2 ???? ???? ?????????????? ???, CORt-??????? AgRP ??? ???? ??????? ???????? ?????????? ????????? ???? ?????? ???? ??, ??? MC4R, 5-HT1B ??? 5-HT2C ?? ?????????? ??????????? ??? ???? ??. ????? ???????????? ???????? ?? 5-HT ?? ???? ????????? ????? ?????? ??.

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???? ??????:

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???????? ?????????? ?????? ????????????? ?? ??????? ????????? ????: ??????? ????????? ????? ???? ????????????? ???? ?????? (P

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??????? ????????? ????? ??? ??? ???????? ???? ????? ?? ???????????? ???: ????-??? ?????????? ??????????????? ??????? ????????? ????? ???????? ?????? ??????? ??? ??? ????? (P

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??????? ??????? ???????? ???????????? ?????? ???????? ??? ??? ????????? ?? ?????????? ???????? ????: ??????????????????? ???????? ??????? ?? ?? ??????? ??????? ???????? ????????????? ARC ????????? c-fos ??? AgRP ?? ?????????? ????????? ???? ??? ???, ?????? LEPR ?? ?????????? ????????? ???? ??? ??? (P

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??????? ??????? ??????? ?????????????? 5-HT ????????? ????? ?? ???????????? ????: ?????????? ????????????? (P

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??????, ? ?????? ??????? ?? ?? ??????? ??????? ???????????-5-HT ????????? ??????? ????????? ????? ???????????? ??? ????????? ?????????? ?????????? ???? ??? ??, ?? ??????? ????????? ??????? ??? ??? ??. ????? ?????????????? ????, ??? ????? ???? ??? (300mg/kg) ???, ????????? 5-HT ?????? ??????????? ??? ??, ???????????? 5-HT1B ??? 5-HT2C ???????????? ?????? ??? ??, AgRP/NPY ?????????? ?????? ??, POMC ?????????? ?????? ??? ??, ??? ????-??????? ??? ???????? ??? ???????? ?????? ???????? ?????? ??? ??.

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? ?????? ????????? ?????????? ???????? ????? ??. ???? ????, ????????? ???????, ??? ???? ????-??????? ????????? ??????? ??? ??? ????????? ????? ??? ????? ??. ???????? ?????????? ?? ?? ????? ?????? ?????? ????? ??????? ????????????? ???? ??? ??, 5-??????????????????????? ???????? ??? ??, ??? ??? ????????????????? ????????? ?????? ??? ???? ??? ??, ?? ????????, ????? ??? ???? ????????? ??????, ???? ????? ???, ??????? ??? ???? ????????? ??????? ??? ???? ??? ??. ? ?????? ????-?????-??? ????? ?????? ?????????? ??? ???? ?????????? 5-??????????????????????? ????????? ???????? ??? ??? ??, ?? ???? ??? ???? ??? ??? ???????? ??? ??? ????????? ??????? ???? ??? ?????? ??? ??????? ?????? ??? ??.

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??????? ?????, ??????? ?????? ?????? ??? ???? ???? ????? ??????? ??? ???? ???? ?????? ???? ?????? ??? ??. ?? ?????, ????? ??????? ?????????? ?????? ?????, ??? ?? ????, ???, ????, ????, ????, ??????? ????? ???? ??????? ????????????? ???? ?????????? ??? ??? ??? ??, 5-??????????????????????? ?????????? ?????????? ??? ??? ??, ?????? ????????? ????????? ?????? ??? ?? ??? ????????? ?????? ?????? ???? ??. ?? ??, ? ??????? ???? ?? ???????? ?????????? 100% ????? ??? ??? ???? ????? ??? ???. ?? ? ????, ?????????? (??? ?? 500 ?????????/?????? ???) ?? ????? ?????? ???? ???????? ?????? ??????? ?????? ???????? ??? ??. ????, ????? ???? ?????????, ????????????? ????? ???? ??? ??? ??, ?????????? ????????? ??? ???? ??????? ?????? ???? ????.

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??????, ??????, ????????, ??? ????? ???? ????? ???? ?? ??????? ?????????? ??? ????????? ??????????? ???? ?????????, ???? ??? ??????? ??? ??? ?????????? ??? ??? ??? ??. ????? ??? ????, ????????? ??? ??????? ??? ????????? ??? ???????? ????? ???? ?????? ??????? ?????? ? ?????? ????? ?????? ??????? ?????? ??. ???????? ??? ????? ???? ????? ????????? ????????? ????? ???? ????, ????? ?????????? ???????????? ?????? ???? ????? ??.

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???????????, ? ?????? ?????????? ???????? ???????????? ??????? ???? ?????? ??????? ????????? ?????? ???????? ??? ??? ??, ??? ???? ??? ????, ??? ???????? ??? ??? ?????????? ?????? ???? ???? ?? ??? ?????????? ???? ???? ??. ??????? ?????????? ???????? ??? ??? ?????? ??????? ?????? ???? ??? ????? ???????? ???? ???? ????, ? ???????? ???????? ???? ???? ????? ?????? ??????? ??? ?????? ??????????? ?????????? ???? ???? ??? ?????? ???? ?????? ??. ?????? ?????? ?? ?? ??????? ????, ????? ????, ???? ??? ??? ????????? ????????? ????? ??????, ???? ?????? ?????? ??? ??????? ????? ??? ???? ??? ??? ???? ???????? ???????? ???? ???.