?????????????? ?????????? ??????? ??????? ????????? ??? ?????? ???????? ????????? ??, ??????? ?????? ??????? ? ????????? ???? ??????? ??? ?? (??? ?? ??????? ?????? ??????? ??? ??????), ?????? ???? ?????? ?????? ???? ????????? ???????? ?????? ????????? ??. ???????? ?? ????? ???? ????? ??, ????? ????? ?????? ???? ???? ??? ???????? ???? ??. ?????? ??????????? ???? ?????????? ????? ???:

?

?, ?????/??????? ????????? ????????

??????? ??? ??????? ?????? ??????? ??? (rUTI) ?? ??????? ?

??????: ??????? ????? ??????? ???????? ???? ??????????? ??????? ??? ??, ?? ??????????? ???? ???? ??????? ????????? ???? ????? ????????? ?????????? ????? ???? ???? ????? ??????????? ???? ?????? ??, ???????????? ????????? ???? ??? ????? ?????? ?????? ?????? ??.

??????:

???????????? ???????????? ?????? ??????? ???? ???? ???????? ???????? ?????????? ?? ?? ?????????? ??????????? ???? ?????? ??? RUTI ?? ???????? ????? 1.5-2 ????? ????? ??? ?????????? ?????????????? ?????? ? ??????? ??, ??? ????? ??????????? ???? ???? ??.

???????? ???????? ?? ???????? (EAU) ???????????? ???? rUTI ?????? (??????? ????: B) ?? ?????? ????? ???????? ??? ??.

?????: ???? ?????? (???? ?????????? ??????), ?????-?????????? ???????????? ??????????? ??? ???? ???.

????????: ???? ?????? ???? ???? ??? ?? ??? ????? ????? ????????? ????????????????? ????? ?? ????? ???; ???-??????????? ???? ?????? ?? ??? ???????? ??.

2, ?????? ????????? ????? ?????? ??????? ?????? ????????

??????? ????????? ???????? (CDG) ?? ??????

?

????????: ?????? CDG ???????????, ??? ?? MPI-CDG (CDG-Ib ??????), ??? ??????????? ????????? (PMI) ?? ???? ??? ??, ?? ?????-6-????????? ?????????-6-?????????? ????????? ????? ?????? ??, ???? ????? ?????? ??? ???????? ??? ??.

??????: ???????? ????? ????? PMI ??????? ?????? ??? ??? ?? ??? ???? ?????-6-??????? ?????? ??? ??? ??, ?????????????? ?????????? ??????????? ??? ??? ??.

????? ?????????:

FDA ? MPI-CDG ???? ??????? ??????? ?????? ??? ??, ?? CDG ?? ???? ?????????? ???????????????? ?? ??.

???? ???, ???? ????? ????? ????? ??? ?????????? ????????? ????????? ??????, ????? ????? ??? ???? ????? ??.

??????: ALG-CDG ???? ???? CDG ??????????? ???? ????? ?????????? ???????? ??????? ???.

??????????? ???????????? ????? ??? ??? ????? ???? (?????? ???????????? ??????)

?

????????:

?????? ???? ??????? ????????: ???? ??????? ????????? (TAMs) ??? ? ?????? ????? ?????????? (MRC1), ??? ????? ??????? ???? ??????????? ???? ????? ???? ???????? ???? ??.

???????????? ?????? ?????: ????? TAM ?? ????? ?? ????? ???????????? ??????????? ???? ?????? ??, ???? ?????? ????? ?? ????? ?????????? ???????????? ????? ????? ?????? ??, ?? ???????????? ????? ?????? ??? ??.

?????????? ??????????? ??????: ????????? ??????????, ????? ??? ?????????? (??? ?? ?????????????) ??? ?????? ?????? ??????? ????????? ???? ?????? ??? ?? (???? ??????? ????????? ??? ?????).

?????: ???? ?????????, ??????? ?????? ??? ??????? ???????? ?? ??? ???????? ???? ??.

????????????/???????? ??? ?????? ??

?

????????: ???????? ????????? ??? ??????????? ???? ??????? ??????? ???? ?? ?????? ???? ???? ????? ????? ?????????? ?? ???? ???? ??. ????? ???? ?????????? ??????? ??? ??? ??.

??????:

?? ?????? ??? ????? ??????? ?????????? ?? ?? ????? ?????????? ????? ???? ???? ???????? ?????? ??? ??.

???????? ?????? ???? ???? ??????? ????? ???????? ????????? (?????? ???????) ?? ??? ???? ????? ??? ??.

??????: ????? ??? ?????? ?????? ????????? ?????? ??? ??? ???????? ?????? ???? ????? ?????.

?, ????? ??? ????? (?????? ????? ???????)

???????? ????? ??? (IBD) ??? ???????? ???????? ??????? ??

?

?????:

????? ???????? ??????????????? ????????? ??? ??? ?? (??????? ???????????? ?????????? ??? ??) ??? ??????? ???????????? ?????????? ?????? ??.

????????????? ?????? ?????? ???????? ???????? ????? ????????? ???????? ?????.

??????? ?????????: ????????? ?????? (????????) ?????? ?????????? ???? ??????? ??, ????? ???? ???????? ???? ??.

??????????????? ??????? ????? ??

?

????????: ???????? ??????, ?????? ??? ???? ?????? ???????????? ???????? ?????????????? ????? ??. ????? ????????????? ?????????????? ??????? ?????? ??? ??.

??????: ??? ???????? ?????? ????, ???? ??? ?????? ???? ??? ? ??? ????????? ??????? ???? ??????.

??????????? ?????????? ?????? ??

?

????: ??????? ????????? ?????? ??? ????? ?????? ?????????? ??? ????? ???-??????????? ????????? (AGEs) ??? ??, ???? ????? ??????? ??? ??? ??. ????? ?????? ?????????? ?? ?????? ??? ??? ?? ??????? ???????? ??? ????? ???, ???? ?? AGEs ?? ?????? ??????????? ???? ????? ??? ??.

??????: ??????? ???? ??????? ??????? ?? ?? ????????? ??????????? ?????? ???? ??? ??? ??, ??? ???? ?????? ???? ??.

?, ?????? ??? ????????

?????????? ????? ??????

?????? ?????? ??????????? ???? ??????? ??????? ??????? ???? ?????????? ??; ????? ?????? ?????? ???? ?????? ?? (??? ????? ??????? ????? ?? ???)

?????? ?????? ???? ?????? ??????????? ???? ??????? ??; ?????? ????? ??? ????? ??? ????? ??.

???? ??????? ?????? ???????? ????????? ???? ??; ??? ????????? ???? ?? ??? ??; ???????????? ???????? ???? ??????? ????????? ?????? ???? ??.

??? ?????? ???????? ?? ????? ??????? ?????? ?????????; ????? ???? ???? ?????? ??????? ??????? ???????? ???? ??.

???? ????? ??????????? ?????????? ?? ????? ??????; ????-???????????? ???????? ???????? ????; ??????? ????????? ?????? ????? ????????? ??? ??.

?, ???????? ??????? ????

?????? ??????? ?????? ?????: ????/???? ??? ???????????? ?????? ???? ????? ??????? ???????????? ?????? ???.

?????????? ?????? ????????????: ??????????????, ?????? ????????? ??????????? ??? ????????? ???? ???? ??????? ???????????? ??????? ???????.

?????? ?????? ??????: ??????? ?????? ??? ???? ???? ??? CDG ??????????? ??? ????????? ??????? ???????? ???? ??????????.

????? ?????? ?????? ?????????-????? ????????????: ??????? ??? ?????? ?????? (??? ?? UTI ?????? ???? ????? ?????) ?? ??? ??.

????? ???????? ?????????: ??????? ?????? (UTI) ???? ???? ???????? (CDG) ?? ?????? ?????? ???