??????? B3, ???? ??????? ????? ?? ???????? ??? ??, ?? ??????? ??????? ??????? ?? ?? ??????? ????? ?????????? ??????? ?????? ??? ??. ????????? ??????? ??????? ?? ?? ??????? B3 ?????? ????? ?????? ???????????? ??? ?? ??, ??????? ?????? ???????? ?????????? ??? ??, ??? ?????? ????????????? ??? ?? ????? ??.

???-?????????? ???? ???? ????? (NAFLD), ?????? ??????? ???? ????? ???????? ???? ??? ??? ??, ?????? 150 ???????? ??? ?????? ??, ??????? 10-20% ???-?????????? ???????????????? (NASH) ??? ??? ????, ?? ????????? ????? ??? ???? ????? ?????? ?????? ????? ??? ??, ?? ?????? ?????????? ???? ??? ??. NASH ????? ?????? ??? ?? ??? ??????? ??? ???? ?????? ???? ????? ???? ???? ?????? ???? ????? ??.

?????????, ?? ???-??? ????????????? ????? ?? ?????? ??????? ???????? JAMA ??????? ??? ???????? "???????? ??????? ?????? ???? ?????????? ????? ??????????????? ??? ??? ??????????. ???? ???? ?????" ????? ?? ?????? ???? ???????? ?????.

????????? ??????????? ?????? ?? ?? ??????? B3 ??? ????, ???? ???-?????????? ???? ???? ??? ?????? ????????? ????-???? ???????? ??????? ?????, ???? ???? ???? (≥26.7mg/????) ?????? ?????????? ????-???? ???????? ??????? 30% ????? ???? ?????????? ????. (≤18.4mg/????) ???? ???? ???? (≤18.4mg/????) ?????? ????????? ??????????.

? ?????????, ???????? 53 ?????? ?????? ???? ?????? 4,315 NAFLD ???????? ????? ????? ???? ?????????? ??????????? ????? (NHANES) ???????????? ??????? ??????? B3 ??? ???? ??????? ?????, ???-?????????? ???? ???? ??? ?????? ????????? ??????? ??????? B3 ?? ???? ??? ????-???? ???????? ???? ??????? ???????? ???????? ??????.

????????? ??????? B3 ?? ?????? ????? ???? ??????? ??????? ??????? ????? ???: ??? ???? ??? (≤18.4 ?????????/????), ????? ???? ??? (18.5-26.6 ?????????/????) ??? ???? ???? ??? (≥26.7 ?????????/????).
?.? ?????? ?????? ????-?? ??????? ???????, ??? ??? ?????? ??????? ???, ??????? ??? ?????? ???? ????? ????? ??? ???.

??????????? ????? ?????? ?? ???? ??? ???? ?????? ????????? ???? ???? ???? ?????? ????????? ???????? ???? ??????? ????????? ???? 30 ??? ???? ????.

??????, ???? ??? ???? ?????? ?????????? ?????????????????? ???????? ??????? 35 ????? ????? ???? ????? ???, ????? ? ???????? ???? ????????? ??????.

??? ??????????? ??????? B3 ?? ???? ??? ????????? ??? ????-???? ???????? ???? ????? ????????? ????????????????? ???? ???, ????? ????????? ?????? ???????? ???????? ???-????????? ????????? ??????????? ??? ????? ???? ?????.

????????? ???, ??????? ? NAD ?????????? ??????????????? ?? ?? ??? ???? ????? ?????? ??? ?????? ???? ?? ?????????? ?????? ??? ???? ??. ????? ????????? ???????? ? ?? ?????????? ?? ?? ??????? ???? ?????? ?????? ??? ?? ??? ??????? ??????? ?????? ????? ??? ??. ???????????? ??????????, ??????? ???? ????????? ??? ??????? ?????? ?? ??? ?????? ??? ??, ??? ???????????? ?????? ??. ? ???? ?????????? ???? ???????, ??????????????? ???????????????? 2 ??? NADPH ???????? ??????????? ???????? ??? ???? ???? ??????? ?????? ??????? ??? ??.

????????? ?? ?? ????????? 2023 ???, ?? ???-??? ????????????? ????? ?? ?????? ??????? ???????? ?????????????? ???????? "??????? ??????? ?????? ??? ???-?????????? ???? ???? ????? ???????? ?????: NHANES 2003-2018" ????? ?? ?????? ???? ???????? ????? ???.

????????? ??????????? ?????? ?? ?? ??????? B3 ???? ???-?????????? ???? ???? ????? ??? ???? ???? ?????????? ????, ????? ???? ??? ?????????? ???? (≥29.2 ?????????/????) ?????????? ???? ???? ?????????? ???? (≤16.3 ?????????/????) ?????? ?????? ???????? ???-?????????? ???? ???? ?????? ???? 31% ???? ????.

?????? ??????? ??? ??, ??????? ????? ?? ?? ??????? B3 ???? ???-?????????? ???? ???? ????? ??? ???? ??? ???-?????????? ???? ???? ??? ?????? ????????? ????-???? ???????? ??????? ????? ???? ?????????? ??. NAFLD ?????? ????????? ????-???? ???????? ?????? ?????? ???? ??????? B3 ?? ??????? ???????? ?????? ???? ???? ??? ???????? ???? ??.