???????? ???? ??????? ????????? ??? ????? ??? ??? ???? ???? ?????? ????? ???. ????? ???????? ????? ????, ???????? ??????????? ?????? ???? ?? ????? ??????? ?????? ??. ????? 1998 ??? FDA ?????? ???? ??? ???????? ??????? ?????? ????. ???? ????? ??? ????? ???? ?????????? ????? ????? ?? ??? ??, ??? ?? ??????? ????????? ?????????? ??? ????? ???. ?? ??????????? ?????? ?????? ???????? ???? ??. ??????, ?????? ????? ?????????? ?????? ?????????? ????? ??? ??? ??? ?? ????? ?????????? ?????? ???????? ?????? ?????? ??? ?????? ????? ?? ?????????????? ?????? ?????????? ????? ??? ??, ?? ??????? ???? ?????????? ?????? ???? ??. ????????? ???????? ?????????? ?? ?? ???????? ???? ????? ???? ???? ??? ?? ??? ????? ??? ?? ????? ?????? ????? ???? ????? ??. ??????? ???? ?????????? ?? ??? ??????? ????? ????? ?????? ???????? ?????????? ?? ?? ???????? ???? ????????? ?? ???? ? ???? ???? ???? ????? ???. ????? ?????? ?????? ?????????? ??????? ???, ???? FDA ? ?????? ??? ?? ?? ?? GRAS (??????) ????? ?????? ??.

?????????? ????? 400 ?? ??? ???????? ???????? ????????? ??? ??, ????? ??????????? ?????, ??????????? ?????, ?????????? ?????, ????? ??? ??? ???????, ?????????? ????? ??? ?????, ???, ???? ?????, ?????????, ???? ????????, ???????? ???? ??? ????? ??????????? ?????? ??? ??. ??? ????????? ????? ??????? ????????? ??????? ???? ????? ???? ??, ????? ???? ???????? ?????????? 87 ?????? ??????? ??. ???? ???? ??? ????????? ?????????? ????? ????? ??????? ????? ?????? ???? ??? ????????? ????? ????? ????? ??, ?? ???????? ???? ?????????? ??????? ???. ? ????????? ??????? ?????????? ??????? ??? ????? ????.