????????????????? ???? ??????????????? ??????? ???? ????????? (????????? 5-?????????? ?????, CDP-??????) ????? ??. ? ??????? ??????? ??? ??? ??? ?????????? ???? ???? ????? ?? [1]. ?????????? ? ?????? ?????, ???? ?? ?????-GPC ????? ??? ???? ?????? ??, ????? ?? ?????? ?????? ???? ??????? ??? ?????? ??. ?????? ????? ????, ??????????? ???? ?????? ????? ???????? ?????? ???? "???????????" ??? ??????? ??????? ??? ???? "CDP-??????" ???????? ????? ?????? [2]. ????? ???????? ????? ???, ?? ?? ??????? ????? ??? ??: ????????? ??? ?????. ??? ????-??? ????? ??? ????? ???, ?????? ???????? ???? ????? ?????????? ??? ???? ????????????? ?????? ???? ??? ?? [3]. ??????????? ??????? ?????? ????? ???? ????? ??????????? ??? ???? ??????????????????? ????? ??. ???? ???????????? ??? ???? ????????? ?????????? ????????? ??? ??. ????, ???????????? ??????? ????? ????? ??? ????? ??? ??? ?????? ??? ??? ?? [4,5,3].

?? ???? ???? ??? ??? ??

????????? ????????????????? ??? ??? ???????? ?????????? ??????? ????? ??. ???????????? ??????, ?? ?????? ?????????????? ??? ?????????? ????? ?? [4,6]. ?? ????? ???? ???????? ????? ??? ?? ??? ???????????????? ??? ????? ??????? ???? ???? ???????? ??? ??? ?? [4,5,2]. CDP ???????? ???????? ???? ????????????????? ??? ??????????????? ????? ??? ??, ?? ?????? ????? ?????????? ???? ?????? ??????? ??? ??. ????????? ????? ??????? ??????????? A2 ?? ?? ?????? ?? ??? ????? ????????????? ?????????? [7,8] ?? ????? ??. ?????????, ????????? ??????????????????? ??????? ????? ??? ????? ???????? ????????? ??? ??-??????? ???????? ???????? ????? ????? ??? ?? [9,10,1].

???? ???????

???? ????????? ??? ?????????? ???????????? ???????? ??? ??. ????? ?????? ???????????? ???? ???????? ??????? ????? ? ?? ?? ???? ???? ????? ????? ??????? ?????????? ????? ????. ??????? ????? ???????? [11,12] ????? ??: ????? ??? (????) ???? ???? ????? ??? ???? ????????? ?? RNA ?????????????? ?? ?? ??????? ???? ??? ????????? ?? (??? ????? ????? ???); ?? ????????????? ?? ???? ??? ?? [13,14]. ????????? ???????????? (?????????, ????????) ??????? ??????? ???? ?????? ??????? ??, ??????: ????? ?????-GPC ????????????????? ???????

??????????? ????????? ???? ????? ??? ??? ??

?) ?????????? ??????

????-??????? ?????????? ????? ?????? ???? ????????? ????? ????? ????? ???? ???? ??????? ?????????? ?????????? ???? ???? ????? ?????? ??? ??. 14 ???????? ?????????? ?????????? ???? ??????? ?? ?? CDP-?????? ?????? ????? ?????????? ????? ?????? ????????? ???????? ??? ???????? ?????? ??? ??? ??, ????? ?????? ???????? ???? ??? ???? ???????? ?? ?????? ??? ?? [9]. 2,800 ?? ??? ????? ???????? ?????? ?????, ????????? ?????? ??????? ???, 21% ????????? ?????????? ??????? ?????? ?? ?? ??? 45% ????????? ??????????? ?????? ???. ? ????????? ??????? ??????????? ???? ???, ???? ???? ????????? ?????? ???? ???? ???? ???? [18]. ????????? (9 ????? ???? 1000 ?????????) ???? ?????????? ????? ?????? 350 ????? ????????? ????????? ???? ???? ?? ?? [19] ????? ????: ?????????? ???????? ????? ???? ?????????????? ??? ?????????? ?????? ?????? ???? ???? ????? ????? ?????? ?????????? ??? ???? ??? ???????? ?????? 210 ???????? ???? ??????????, CDP-?????? ????????, ??????????? ??? ??? ???????? ?????? ??? ??. ????????? (2000 ?????????) ?? ?????? ????? ????? ??? ??, ????? ???? ??? [20,21,22]. ??? ???? ????????? ???????, ???????? ?????? ??? ?????????? ??????? ????? ???? ??????????? ????? ??? ??. ???? ???? ?? ????? ????? ???? ?????? ???? ??????? ??? ??? ??... 135 ?????? ????? ???? ???? ?? ?? ???????? ???????????, ????????? (250-500 ?????????) ? ????? ??? ?????? ??????????? ?????? ????? [23,24]. ????? ??? CDP ????? (250 ?????????) ?????? ????? 60 ????????????? ?????????? ?????????? ????? ????? ??? ??????????? ??? ???????. ????? ?? ??????? ??????? ?? ??? ?? ?????????? ???? ??? ??? ?? [25]. 24 ?????? ????? ???? ???????, ????????? (500 ???? 1000 ?????????) ?? ???? ????? ????? ?????????? ???????? - ?????????? ?????, ????????? ??? ????? ????????, ???????????? ?????? - ??? ?????? ??? - ????? ???? ???? ?????????? ?????? ?????? ??????? [26]. ?? ? ?????????, ????????? ????????? ??????? ?? ??? ??? ??? ? ??? ??? ???? ???????? ?????????? ???? ??????????? ?????????? ?????? ?? ???. [26] ????????? ?????????? ?????????? ????????? ????? ???. ?? ??????? ??????? ???????? ????????? ?????????, ????????? (? ???????? ???? ????? ?,??? ?????????) ? ???????? ????????? ??????? ??? ?????????? ?????????? ?????? ?????. ??? ??????? ???????? ????? ?????? ???, ??? ??????? ????? ?? ?? ??????????? ???? ????? ?? ??????? ?? ?????? ??? ??? ??? ?? [??,??]. ????????? ?????? ????, ????????? ????? ??? ?????? ???????? ????? ??? ??, ??? ????? ???? ?????????? ??????? ?????? ???????.

?) ??????? ????????????

????? ?????? ????????? ???? ?????? ??? ?????? ?????????? ??? ?? ??? ?? ??? ????? ????? ?????? ?? ??? ??. ????????? ???? ????? ????? ????? ??? ????? ?????? ????????? ??????? ????? ??? ??? ??? ?? [29,30]. ??? ???????? ?????? (1,300 ?? ??? ??????) ?? ????-???????? ????, ??????? ??? 24 ?????? ???? 2000 ????????? ????????? ?????? ??????? ?????? ????? ?????? 38% ??? ?? ?? [10]. 4,000 ?? ??? ??????? ??? ????? ?????? ???? ??????? ?? ?? ????????? ??????? ??? ????? ??????????????? ?????? ??? ??; ???? ??? (2000-4000 ?????????) ??? ??????? ??. ? ????????? ??? ??????? ???????? ??????, ???? ??? ?????? ???????? ???? ????? ??? [31]. 3,000 ?? ??? ???????? ?? ?????????? ????? ??????? ???? CDP-???????? ??? ????????? ????? ???? ????? ??? [32,33]. ????????? ??? ?????? ???? ????? ??????? ???? ????? ?????? ??? ??. ?? ??????? ???????? ???? ???? ?? ?? ????????? ??????? ????? ???? ???? ??? ?? ???? ??? ???????? ??? ??? ??? ?? ??? ????? ???????? ?????? ????? ???? ??? [34,35]. ???????????? ????? ????? ??????? ????????? ?????? ??? ??? ??, ????? ?????? ???????? ??. ????? ??????? ???? ????????? ??? ???? ???? ????? ?????? ??? ??.

?) ????????? ???????

??? ??? ???????????? ???????? ????? ?????? ???, ????????? ?????? ???? ?? ???? ????????? ??? ??? ??? ??. ?? ?????? ?????????? ????? ???????? ?????? ??? ?? ??? ????? ?????? ????????? ??? ??? ??? ?? ??? ?? [1]: ?????? ????????? ???????? ???????????? ???????? ????? ??????? ????? ??? ???? ?????? ?????? ?????? ?????? ???????? ??? ?? ??? ???????? ??? ???? ??? ??, ?? ??????? ??????? ?????? ??? ???? ??? ?? [36]. 80 ???????? ????????? ?? ???????? ???????????, ????? ?????? ????? ?????????? ?????? ?????? ???????????, ?????????? ?????? ????? ??? ????? ?????? ???? ??? [37,38]. ????????? ????? ?????? ?? ???? ???????? ??????????? (68 ??????) ???? ??????? ????????? [39,40]. ????????????, ???? "???? ???," ?????? ??? ?? ?????? ???? ??? ??? ???? ???? ?????? ???? ???. ?? ?? ?????? ????? ?????????? ???? ??? ??? ??. [41] 190 ??????? ???? ???????? ???????????, ????? ?????????? ????????? ???????????? ?????? (????? ???) ??? ?????? ????? [42,43,44]. ????????????? ?????? 10 ????? ???? ??????? CDP ????? (1000mg ?????) ?? ??????????? ?????? ???? ???? ??? ??? ?????????? ?????? ???. ????????? ???? ?????? ?? ??? ??? ????? ??????? ??????????? ???? ???, ???? ??????? ???????? ?? [45]. ?????? ????????? ?????? ????????? ? ?????? ???? ????? ???? ?????? ?? ?? ?????????? ??? ??? ??? ??. ?????? ????????? ?????? 26 ?????????, ????????? (2 ????? ???? 1600mg/????) ???? ???????? ???????? ?????????? ?????? ????? [46]. ?????? ?????? ? ???????? ????? ????????? ?????? ???? ??????????? ??????? ?????? ???? ???? ??? ????? ???????? ?????? ???. ???? ???????? ?????? ???????, ???-?????? ??????? ???? ???-???????????? ???????? ???????? ?????? ?? ?? ??? ???? ??? ????. ?? ??, ????? ????? ????? ????????? ?????? ?????? ???? ????? ??????? ? ????? ????.

?) ????? ???

?????????? ????, ??????????????? ???????????? ??? ?????????? ??? ????? ?????? ????? ?????? ???????? ??? ??. ????????? ??? ??? ??????????? ? ????? ????? ??? ??, ?????? ?????? ?????? ???????? ??? ?? ??? ?????????? ??????????????????? ????? ??. ???????? ??? ???? ???????? ???????????, ????????? (1-3 ????? ???? ????? 1000 ?????????) ? ???????? ????? ????????? ?????? ????? [47,48,49]: ??????? ?????? ??????? ?????? ???? ???????? ???????? ??? ?? ????? ??????? (?????????? ??? IL1B) ?? ??????? ????? ??? ??. ?? ??, ???? ?????????? ??????? ??????????? ????? ??????? ???????? ???????. ?????? ?????????, ???????? ??? (APOE-e4 ?????) ???? ???????? ??? ?????? ??????? ??? ???????? ????? ?????. ? ?? ?????????? ??? ?? ???? ?? APOE-e4 ????? ????? ?????????? ???? ??? ???? (??? ?????? ????) ???????? ??? ?? [48,50]. ????????? ???????? ??? ???? ??? ??????? ?????? ????? ??? ?? ??? ?? ???????? ???????? (600 ?? ??? ??????) [51,52] ?? ?????? ???? ??? ??. ???????? ??????? ????????, ????????? ??????? ??????? ?????????? ????? ??? ?? ??? ???? ?????? ????? ??. ???????, ???????? ??? ?????????? ?????? ??? ??????????? ?????? ??? [53]. ????????? ???????? ????? ????????? ??? ???? ???????? ?????? ??????? ??? ??? ??? ??, ????? ????? ???????? ?????? ???? ??. ?????????? ??? ?????????? ?????? ???????? ?????????? ????? ????????? ????, ???????? ??? ???? ????????? ???? ??? ??. ?????????? ??????? ????????, ????????? ?????? ??????????? ???? ??????? ????????? ???? ??? ??? ??. ?? ???? ???????? ????? ?? ????? ?? [54,55]. ??????? ??????????? ????? ???? ????? ?????? ?????? ????? ????? ??????? ????????????? ???????? ??? ??? ??, ???? ???? ????? ??????? ??? ?????????? ????? ?? ??? ??. ??????? ??????????????? ??????????, ??????????? ?????? ???????????? ??? ???? ??????? ?????? ???? ??????????? ?????????? ?????? ?????? ?? [56,57].

?) ?????? ??????? ??? ???? ?????????? ?????

???????? 50 ???????? ?????????, ??????????????? (???????????) ??? ????????? ???????? ????????? ?????? ??? ??????????????? ?????? ??? [58]. ????????, CDP-?????? ????? ????????, ??? ??? ???????? ??????????? ??????????????, ???????? ??? ???????????? ???? ????? ?? [59,60]. ?????????????? ??? ?????? ?????? ?????????? 60 ?????????????? (???) ?????????? ????????? ?????? ???????, ????? ?????? ????? ?? ??? ??? ??? ???? (3 ????? ???? 2000 ?????????/????). 31 ?????????????? ????????? ???? ?????????, ?????????? ????? ???????? ?????? ??? ?????? ????? ??????? [61,62]. ??????? ???????? ?????? 130 ?? ??? ?????? ??????????, ????????? (3 ????? ???? 500-2,000 ?????????) ?????? ????? ??????? ????? ????? ??? ??? ????. ?? ??, 20 ???? ?????? ????????????? ?????????, ???? ??? ??? ?? ???? [63,64,65]. ?? ?????????? ?????????? ???? ???????? ?? ?? ??????????? ???????? ?????, ??? ????? ?????? ?? ???? ????? ?? ??? ??, ????? ????? ???????? ????????? ???????? ?? ??? ???????? ????? ?? [66]. ?????????? ?????????????? ?????? 66 ????????? ????????? ???????? ?????? ????? ?????. ?? ????????? ??????, ???? ?????? ??? ???? ???? ??????? "?????????" ????????? ?????? ??? ??. ???????? ???? ???? ??? ?????? ???? ??? ????? ??????? ?? [67]. 24 ?????? ????? ???? ???????, CDP-????? ????????? ???????????? ?????????? ???????? ????? ???????????? ????? ??, ?? ??????? ???? ????????????????? ??? ?????? ??? ?? [26]. ????????? ??????? ??????? ??, ????? ?????? ??????? ??? ???? ??????? ?????? ???? ??????????? ??????? ?????? ???? ???? ????? ?????? ???.