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    2. ????? (???? ??-?????) ?? ???? ???? ??, ????? ????????? ??????, ???????? ???? ????? ??? ???? ?????? ??????? ???? ???? ???, ??? 90% ????? ???? ???? ??? ???? 30 ?? 60 ????? ??? ???? ????? ?????? ???? ???????? ??? ??, ???? ????????? ??????, ????? ???? ?????? ??? ????? ???, ????? ???????? ??? ? ????????? ??. ????? ??????? ????????? ??? ??? ??? ??, ?????? ?????? ?????? ??? ??, ???????? ????????? ????????? ??? ??? ?? ??? ???????????? ???????? ??? ?? ??? ??. ??????? ?????? ????????? ??????? ?????? ?????? ???????? ?????? ??? ???? ???????? ??????? ??????? ?????? ???? ??.
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      1980 ?? ???????, ?????????? ??? ?????? ?????? ??????? ?????? ??????? ????? ?????? ???? ??????? ????? ??????? ??? ??. ???????? ????????, ??????? ?????????? ??? ?????? ?????? ????? ???? ?????? ?????? ??????? ????, ??????? ?????? ??????? ????? ????????? ??????? ?????? ???? ???? ????? ???????? ?????? ????? ??????? ??? ??? ??.
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      ?????? ?????, ???????? ??? ?????????? ?????? ???????? ??? ??, ?????? ????? ?????? ???? ??????? ?????? ???? ??????? ???? ??? ???????????? ???? ????, ???? ????? ?????????? ???????? ??? ??????? ????? ?????? ???? ???????? ?????? ????, ???? ????? ?????????? ????? ????? ??????? ???, ??? ?? ?????????? ??????? ????? ??????? ???? ???? ??? ?? ??????? ????????? ???? ?????. ????????? ??????? ?????? ??????? ??? ????????????? ??????????? ???? (UPEC) ?? ????? ??? ??. UPEC ?????????? ????? ?????? ????? ?? ????? ???? FimH ??????? ?????? ????? ?? ??? ????? ?????? ??????? ????? ????? ???. ???? ???????? (M4284) ?????? ???? ???????? ?????? ?????. FimH ??????? ???? ????? ????? ????? ???? 100,000 ???? ????? ??, ????? ?? ?????????? ????? ?? ???? ?????? ??? ??? ???????? E. coli ???? ???????? ??? ???? ??.
      2016 ?? ????????????? ?????????, ?? ??????? 13 ???? ???? ????? ????? ???? ????? ????????? ????????? ????? ??? ??? ??? ?????????? ?????? ????????? ???? ????? ?????? ??????????? ????????? ?????? ??? ???. ??????? ??? ??????? ????? ????? ????, ???????? ???????? ?? ??????? ??????? ????? ???, ????????? ???? ????? ??????? ???? ??????? ????, ???????? ??? ???? ??? ??????. ????? ?????? ??????, ? ???????? ???? 4.5 ??? ??????????, ?????? ???????? ????? 33.3 ??? ???. ???????? ???? ??????? ???? ?? ????? ????? ??????? ????? ????????? ??? ??? ??? ?? ??? ??????? ????? ???????????? ??????????? ?????? ??? ??.