??????? K3 ?? ?????????? ??

???????? ??????? K3 ?? ?????????? ??, ???? ????? ??????? K ?? ????? ????? ??? ?????? ??????????? ?????? ?????? ???? ?? ??? ??. ?? ??????????????? ?????? ?????????? ??? ??? ??, ??? ????? ????????????? ??? ?? ??, ?? ???? ?????? ????? ??? ??. ??????? ??????? K3 ?? ????? ????????? ???? ??????? ????? ????? ??? ??.

????? ?????? ???

??????? ?????

????

(?) ??? ?????: ????? ????? (??.?. ??????, ???, ?????? ?????, ?????); ???? ????? (??.?. ?????, ?????? ?????); ???????????? ??? ???????? (??.?. ????? ??, ??? ????? ?????, ????, ?????? ????? ?? ???????? ?? ?????); ?????? ??? ????? ????? ????? (??.?. ?? ????, ?????, ?? ??? ??????? ?????).

(2) ?????? ?????: ?????????? ??? ????? ???? ????????; ???????? ??? ??????? ???????????; ???????? ?????? ??? ??????? ???? ?????????? ????? ??? ????????; ??????? ?????? ????, ???? ??? ??????? ???????? ?????; ???? ??????? ?????????? ?????; ??? ??????????? ????? ??????? ?????? ????????????? ??????? ????????? ????? ???? ??? ??. ??????? ??????? ???????? ?????? ??? ????? ?????? ??? ??????? ????????? ?????? ???? ????? ??? ??; ??? ?????????, ?????.

(?) ?????????????? ?????: ???????? ?????, ??????? K, ??????? A, ?????????????? ????????????? ??????? ?????????? ???????? ???????????.

?????2

??????

1. ??????? K3 ???? ????? ????? ?????????? ??? ??, ??? ??????? K3 ?????????????? ??????????? ????????? ??? ??? ??.

2. ??????? K3 ????? ????????? ????? ??. ??????? K3 ? ??? ????? ???????? ?? ?????????? ??? ?? ??? ??????? ?????????? ???????????????? ????????? ??????? ??.

3. ??????? K3 ????????? ????????????????? ????? ??? ??, ?? ???????? ?????????? ?????????? ??? ??? ??, ???? ????????? ????????? ???????? ??? ??? ??, ??? ?? ??????????? ??????? ??????? ????????? ??? ??.

?. ??????? K3 ?? ????? ???????? ???????????? ?? ??? ??, ????????? ???????????, ?????, ????? ????????????, ?????? ????? ??????? ?????? ????.

??????? ??????????

?????	????
???????? ???? ?????????	?. H-NMR: ??????? ???? ?????? ???? ???? ???? ??
	2. HPLC-MS: ????? ??? ?? ????? ???? ??? ??????? ??????? ?????? ??? ?????? ???? ???? ???? ??.
	?. IR: IR ?? ???? ?????? ???? ???? ???? ??
??????? (HPLC)	≥??.?%
??????? ????????	?????? ??? ???????	EP/USP/BP ??????? ????? ??? ??
	???-??????? ??? ???????	≤0.10%
	??? ????????	≤0.50%
?????? ??????	EP/USP/BP ??????? ????? ??? ??
?????? ?? ??????	≤?.?%
????	≤?.?%
????????? ?????	≤0.1%
???? ?????	≤?? ??????
???????	??.?%~???.?% (EP/USP/BP ????? ??????)
????????????????? ????????
??? ????? ??????	≤1000cfu/?????
????? ??? ?????	≤100cfu/?????
?. ????.	???????
??????????	???????
??.?????	???????