A dabi'a, mannose yana wanzuwa a cikin 'yanci a cikin wasu 'ya'yan itatuwa, kamar cranberries, apples, lemu, da dai sauransu. A cikin jikin mutum, mannose yana rarraba a cikin dukkanin kyallen takarda da jini, ciki har da fata, gabobin jiki da jijiyoyi. A cikin wa?annan kyallen takarda, mannose yana shiga cikin ha?in glycoproteins wa?anda ke daidaita aikin tsarin autoimmune. Binciken da aka yi a asibiti a baya ya nuna cewa manno na iya yin magani da kuma hana kamuwa da cutar yoyon fitsari, don haka ana amfani da wasu kayayyakin kiwon lafiya na kasashen waje tare da mannose a matsayin babban bangaren kula da lafiyar tsarin yoyon.

An dade da sanin cewa ciwace-ciwacen daji suna da bu?atun glucose mafi girma fiye da kyallen takarda. Kwayoyin Tumor na iya ?aukar nauyin glucose har sau 10 kamar sel na yau da kullun kuma suna dogaro da glycolysis don kuzari don ci gaba da ha?aka cikin sauri. Duk da haka, ciwon sukari "sugar kamar rai", a fuskar mannose, amma wani yanayi na daban ya faru. A cikin 2018, Mujallar Nature ta buga wani bincike mai ban mamaki daga Cancer Research UK cewa mannose na iya hana ciwace-ciwacen daji. Masu binciken sun gano cewa bayan mannose ya shiga cikin kwayoyin cutar kansa, yakan taru a cikin sel a cikin nau'in mannose 6-phosphate, yana toshe tushen makamashin ciwon ta hanyar yin katsalandan ga glucose metabolism, don haka yana hana ha?akar ?wayoyin tumor. Domin tabbatar da wannan matsaya, masu binciken sun gudanar da wani bincike a kan samfurin ciwon linzamin kwamfuta, sun kara mannose a cikin ruwan shan wadannan berayen na “Cancer”, tare da kimanta tasirin mannose na baki wajen magance nau’o’in ciwon daji kamar ciwon daji na pancreatic da ciwon huhu a jikin beraye. Sakamakon ya nuna cewa sarrafa mannose ta baki ta hanyar shan ruwa yana haifar da jinkirin ha?akar ?ari a cikin berayen. Bayan tabbatar da tasirin maganin mannose a cikin samfurin ?wayar linzamin kwamfuta, masu binciken sun yi la'akari da ba da mannose ga beraye baya ga chemotherapy don maganin adjuvant, kuma sun yi mamakin ganin cewa mannose yana inganta tasirin maganin chemotherapy, ba wai kawai yana kara rage yawan ?wayar ?wayar cuta a cikin berayen ba, har ma yana kara tsawon lokaci na "mice". A wannan shekara, ?ungiyar bincike ta Jami'ar Fudan ta samo wata sabuwar hanyar maganin cutar sankara ta mannose - tana daidaita ?wayoyin rigakafin PD-L1. Menene wurin bincike na rigakafi? Mu sani cewa idan jikin waje irinsu bakteriya da ?wayoyin cuta na waje suka mamaye ko ?wayoyin da ke cikin jiki suka mutu ko suka kamu da cutar kansa, aikin rigakafi na jikin ?an adam zai fara aiki, kuma tsarin garkuwar jiki zai taka rawa bayan an kunna shi don cire wa?annan “ba?in ?wayoyin cuta”. Har ila yau, don guje wa yawan kunna garkuwar jiki da kuma "kisa ba tare da nuna bambanci" na kwayoyin halitta na al'ada a cikin jiki ba, akwai wani tsari na "kwayoyin kariya na rigakafi" a cikin jikinmu. PD-L1 wani muhimmin ma'aunin bincike ne na rigakafi a cikin jikinmu, wanda zai iya ?aure ga kwayoyin PD-1 akan saman ?wayoyin rigakafi kuma ya aika siginar "birki" zuwa ?wayoyin rigakafi don guje wa kashe kwayoyin halitta ta hanyar kwayoyin halitta (Hoto 2). Duk da haka, wannan tsarin birki a jikinmu yana amfani da ?wayoyin tumor masu wayo, kuma ?wayoyin T a cikin ?ananan ?wayoyin cuta suna da alhakin kashe ciwace-ciwacen daji, kuma ?wayoyin tumo za su saki sigina na "birki" zuwa kwayoyin T ta hanyar babban nau'i na kwayoyin PD-L1, suna hana ayyukan kwayoyin T, don kauce wa kashe tsarin rigakafi.

Kwayoyin PD-L1 sunadaran furotin ne mai wadata a cikin gyaran glycosylation. ?ungiyar bincike ta Jami'ar Fudan ta gano cewa mannose na iya lalata kwanciyar hankali na furotin PD-L1 ta hanyar daidaita glycosylation na kwayoyin PD-L1, don haka inganta lalata kwayoyin PD-L1. Don haka, lokacin da kwayar halittar PD-L1 da aka bayyana sosai a cikin ?wayoyin ?ari ta lalace ta mannose, shin ?wayoyin tumor ba za su iya tilasta ?wayoyin T su “birki” ba? Masu binciken sun tabbatar da hasashe: ?wayoyin tumor da aka bi da su tare da mannose sun fi iya kashe kwayoyin T; A cikin ?irar ?wayar ?wayar cuta ta linzamin kwamfuta, mannose na baka zai iya inganta mamayewa da kashe ?wayoyin T zuwa ?wayar cuta da kuma hana ci gaban ?wayar cuta, da ha?uwa da mannose da magungunan rigakafi na rigakafi yana kara inganta mamayewa da kashe kwayoyin T zuwa ciwon daji, kuma yana kara tsawon rayuwar "cancer" mice.

Kamar yadda muka ambata a baya, ana samun mannose ta dabi'a a cikin wasu 'ya'yan itatuwa, musamman cranberries tare da mafi girman abun ciki na mannose (Hoto na 3). Mutane da yawa na iya yin mamaki, shin cin cranberries zai iya hana ko magance ciwon daji? Hasali ma yawan mannose da aka baiwa berayen ''Cancer'' a cikin binciken biyun da suka gabata ya kai kashi 20 cikin 100, wanda hakan ke nufin cewa kowane 100ml na ruwan sha yana dauke da gram 20 na mannose, wanda yake da yawa sosai da kuma kashi. Saboda haka, muna ci cranberries da sauran 'ya'yan itatuwa don ?ara yawan ci na mannose, zuwa wani matsayi, na iya inganta rigakafi, m ga kiwon lafiya, amma so a cimma sakamakon anti-ciwon daji cranberries kadai ne nisa daga isa.