1.1 Daga gyaran gyare-gyaren tantanin halitta zuwa tsarin Cerebrovascular

Tun da Takeda Pharmaceutical na Japan ya fara ha?a Citicoline a cikin 1956, ana iya ?aukar tarihin aikace-aikacen sa azaman tarihin ha?aka fahimi:

• 1980s:Ana amfani da shi azaman wakili na gyara membrane bayan bugun jini

• 2010s:An gano cewa yana iya ?ara ha?akar jini na cerebral (PET-CT ya nuna karuwar 23% a cikin jini na lobe na wucin gadi)

• A shekarar 2024,NIH na Amurka ya jera shi azaman ma?alli mai mahimmanci don "ha?in kai na jijiyoyin jini"

1.2 Ha?aka ha?akar fashewar kasuwar duniya

Dangane da bayanan Evaluate Pharma:

Kasuwancin duniya ya kai dalar Amurka biliyan 4.7 a cikin 2024 (CAGR 12.3%)

Amfani da miyagun ?wayoyi a asibitocin samfurori a China ya karu da 400% a cikin shekaru uku

An fa?a?a alamun zuwa:

?wa?walwar jijiyoyin jini (MMSE ya inganta da maki 2.1)

Raunin kwakwalwa mai rauni (ma'aunin hasashen GOS ya karu da maki 1.5)

Babi na Biyu: Bakin Akwatin Crack of the Mechanism of Action

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2.1 Hanyoyi na ayyuka sau uku

Matsayin tasirin sakamako na manufa: Ha?in phosphatidylcholine yana gyara mutuncin membrane neuronal Class I: Acetylcholine precursors ha?aka watsawar neurotransmitter Class II: Nitric oxide synthase tsarin inganta microvascular dilation (diamita karuwa da 18%) Class IIB

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2.2 Lokacin taga zinare na asibiti

Nazarin 2024 na Asibitin Ha?in Kan Farko na Jami'ar Sun Yat-sen ya nuna:

Allurar 1000mg na cikin jijiya a cikin sa'o'i 6 bayan raunin kwakwalwa na iya ceton yankin penumbra na ischemic har zuwa 7.2cm.3

Koyaya, babu wani bambanci mai mahimmanci lokacin da gwamnatin ta wuce awanni 72 (p=0.34).

Babi Na Uku: Rigimar Rigima

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3.1 Shakku game da Inganci

Jagororin NICE na Burtaniya: Ana la'akari da cewa shaidar da ke akwai ba ta isa ba don tallafawa ?aukar inshorar lafiya (daidaitaccen ?imar ￡ 45,000/QALY)

Lancet Neurology ** 2025 Meta-Bincike: Babu wani babban bambanci daga placebo a cikin rukunin rashin lahani mai laushi (p=0.21)

3.2 Hargitsi a Ci gaban Kasuwanci

Sanarwar Hukumar Kula da Kayayyakin Kiwon Lafiya ta ?asa ta 2024:

Kamfanoni goma sha biyu sun wuce gona da iri (inganta "maganin jiyya" a matsayin "juyawar dementia")

Gwaje-gwaje akan wani dandalin kasuwancin e-commerce sun nuna cewa ainihin abun ciki na 32% na shirye-shiryen baka bai wuce 70% na adadin da aka yiwa alama ba.

Babi na Hudu: Gaban Cigaban Fasaha

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4.1 Sabon Tsarin Isar da Magunguna

Shamakin jini-kwakwalwa yana shiga peptide gyara liposomes (Patent of Peking Team Team, CN202410123456.7)

Microneedles masu ?orewa mai ?orewa (Gwajin na dabba a Jami'ar Kasa ta Seoul a Koriya ta Kudu ya nuna ha?akar ha?akar halittu sau uku)

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4.2 Alfijir na Magungunan Mutum

Binciken hadin gwiwa na Bgi ya gano cewa:

Sakamakon magani na CDP-cholinesterase gene polymorphic yawan (lissafin 31% na yawan mutanen Asiya) ya karu da 47%

Babi na Biyar Bayanan Marasa lafiya na Gaskiyar Duniya

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5.1 Al'amuran Masu Amfani

Rikodi daga wani babban asibiti a Hangzhou: Bayan ha?in gwiwar jiyya, ikon ajiyar jini na majiyyaci mai shekaru 62 da ke fama da ciwon kwakwalwa ya murmure daga 32% zuwa 89%

5.2 Maganar kai na jam'iyyar mara inganci

"Daukar shi tsawon rabin shekara a ci gaba, kashe yuan 300 a kowane wata ya haifar da rashin jin da?i a cikin ciki kawai" - tarihin hira da Madam Li, wata majiya ce daga birnin Beijing.