Fiye da mutane miliyan 500 a duniya suna da ciwon sukari, kashi 90% na su suna da nau'in ciwon sukari na 2. Marasa lafiya suna bu?atar sarrafa canjin sukari na jini don rayuwa, kuma an jera sukari na gargajiya (kamar sucrose da fructose) azaman abubuwan da ke hana abinci saboda suna haifar da hauhawar jini kai tsaye. Koyaya, bu?atun ilimin halittar ?an adam na ?an?ano mai da?i yana da wahala a kawar da shi, kuma samfuran maye gurbin sukari sun kasance. Sucralose, a matsayin mai zaki na ?arni na hu?u, ya ja hankalin mutane da yawa don "kalori sifili da kayan zaki" 13.

2. Halayen metabolism da amincin sucralose
1. Metabolic amfani
Tsarin kwayoyin halitta na sucralose yana canzawa ta hanyar chlorination, wanda ba ya lalacewa ta hanyar enzymes masu narkewa. Kimanin kashi 85% na sucralose ana fitar da su kai tsaye ta cikin hanji bayan an sha, sauran 15% kuma ana samun su cikin maha?an marasa guba ta hanta kuma ana fitar da su a cikin fitsari. Nazarin asibiti sun tabbatar da cewa ma'aunin glycemic ?in sa shine 0, kuma babu ala?a kai tsaye tare da ?oyewar insulin ?12. Misali, gwajin sarrafawa ta 2024 ta ?ungiyar Ciwon sukari ta Duniya (IDF) ta nuna babu wani muhimmin canje-canje a cikin glucose na jini mai azumi da matakan A1C a cikin marasa lafiya 50 masu fama da ciwon sukari na 2 wa?anda suka cinye abin sha na sucralose na kwanaki 30 a jere ?5.

2. Binciken yare na rigingimun tsaro
Kodayake bincike na yau da kullun yana tallafawa amincin sa, har yanzu akwai damuwa game da ha?arin ha?ari:

Gut microbiota tasirin: Wani bincike na 2024 da aka buga a Nature Microbiology ya nuna cewa cin abinci na yau da kullun na fiye da 15g na sucralose ya hana ayyukan probiotics kamar bifidobacterium, wanda ya haifar da raguwar 20% -30% a cikin nau'ikan microbiota na gut ?37;
Mu'amalar miyagun ?wayoyi: Lokacin da aka ha?a shi tare da warfarin na anticoagulant, sucralose na iya rage yawan ?wayar ?wayar cuta ta 12% -15%. 27 ya kamata a dauki 2 hours baya;
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Ha?arin aiki ta hanyar samfur: yin burodi mai zafi (> 150 ℃) na iya haifar da adadin chloropropanol (Na uku, dabarun kimiyya na maye gurbin sukari
1. An daidaita sarrafa sashi zuwa wurin
Hukumar Lafiya ta Duniya (WHO) ta ba da shawarar cewa mutanen da ke fama da ciwon sukari su cinye fiye da 9mg/kg na sucralose kowace rana (kimanin 540mg ga babban mutum 60kg). Ana bu?atar bambanta yanayi a aikace-aikace masu amfani:

Abin sha: Abincin abinci na 300ml ya ?unshi kusan 30mg sucralose, wanda shine kawai 5.5% na amintaccen iyaka 16;
Kayan gasa : Zabi irin kek ?in da aka yi ta hanyar ?ananan zafin jiki (2. Hadaddiyar sarrafa abinci
Abubuwan maye gurbin sukari ba su zama madadin sarrafa sukari gaba?aya ba:

Daidaitaccen abinci mai gina jiki: Ha?a dukan hatsi (GI da ke ?asa da 55) da fiber na abinci (25-30g kowace rana) don jinkirta ?aukar glucose ?46;
Kulawar glucose na jini: An gano glucose na jini sa'o'i 2 bayan cin abinci maimakon sukari, kuma an kafa tarihin mayar da martani na mutum 58.
4. Ka'idojin masana'antu da ilimin masu amfani
1. Daidaita alamar abinci
Sake fasalin Babban Dokokin Kasar Sin don Lakabin Abincin da aka riga aka shirya a shekarar 2025 yana bu?atar cewa abincin da ke ?auke da sucralose ya kamata a yiwa alama da garga?in "masu ciwon sukari suna bu?atar sarrafa jimlar yawan shan carbohydrate" kuma suna nuna abun da ke cikin ?ari (mg/100g) ?24.

2. Amsa hargitsin kasuwa
A cikin 2024, Babban Gudanar da Kula da Kasuwa ya gano cewa kashi 18.7% na "marasa sukari" yana adana zahirin ?ara glucose, yana nuna sucralose. Ya kamata masu amfani su za?i samfuran tare da takaddun shaida na SC da cikakkun rahotannin gwaji ?78.

5. Jagoran Ci gaban Gaba
1. ?ir?irar fasaha
A cikin 2025, masana'antar Jinhe ta ?addamar da tsarin "chlorination da aka ba da umarni" don rage ragowar adadin sucralose chloropropanol zuwa 0.01ppm, kuma ya tsawaita lokacin sakin hanji ta hanyar fasahar microcapsule don rage damuwa na kwayan cuta 18.

2. Binciken likita na tushen shaida
?ungiyar Ciwon sukari ta Duniya ta ?addamar da shirin "maye gurbin sukari da ciwo na rayuwa" na shekaru 5 don tantance lafiyar sucralose na dogon lokaci a cikin mutane 100,000 masu ciwon sukari.