Wannan bita ce ta kwanan nan, wacce aka buga a babbar mujallar Nutrients a cikin Fabrairu 2024, ta Ligia J. Dominguez da wasu daga Jami'ar Palermo da Jami'ar Enna a Italiya. Sun yi nazari akai-akai game da dangantakar dake tsakanin magnesium da alamun tsufa a cikin jikin mutum, kuma sun gano cewa wannan ma'adinai na yau da kullum na iya rage yawan tsufa, abin mamaki!

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Mahimman shawarwari:

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1. Magnesium shine kashi na hudu mafi yawan ma'adinai a cikin jikin mutum kuma yana da ala?a da ayyukan fiye da 600 enzymes, yana shafar matakai daban-daban na ilimin lissafi.

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2.Rashin Magnesium yana da yawa a cikin tsofaffi, wanda ke da ala?a da abubuwa da yawa kamar kwayoyin halitta, yanayi da salon rayuwa. Rashin isasshen matakan magnesium a cikin jiki zai iya hanzarta tsarin tsufa.

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3. Nazarin ya gano cewa magnesium na iya rinjayar 12 key fasali na tsufa, ciki har da rashin zaman lafiya na genomic, telomere shortening, da epigenetic canje-canje. Ana sa ran kari na Magnesium zai jinkirta tsufa da inganta tsammanin lafiya.

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Anan ga cikakken ta?aice na ainihin labarin:

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Rashin Magnesium yana ha?aka halayen tsufa 12

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Rashin zaman lafiyar kwayoyin halitta: Magnesium yana daidaita tsarin DNA guda biyu na helix kuma yana shiga cikin hanyoyin gyaran DNA iri-iri. Karancin Magnesium na iya haifar da tarin lalacewar DNA, ha?akar maye gurbi, da ha?akar tsufa.

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Gajartawar Telomere: Telomeres ana maimaita su ne a ?arshen chromosomes wa?anda ke kare kwayoyin halitta daga lalacewa. Magnesium yana tabbatar da ?arshen.

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Canje-canje na Epigenetic: Canje-canje na Epigenetic a cikin maganganun kwayoyin halitta suna faruwa ba tare da canza jerin DNA ba. Magnesium yana sarrafa hanyoyin epigenetic kamar DNA methylation da gyaran tarihi.

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Protein homeostasis rashin daidaituwa: gina jiki kira da lalacewa a cikin tantanin halitta sun kai ga ma'auni mai ?arfi, wanda ake kira homeostasis protein. Magnesium yana da hannu wajen daidaita aikin proteasome da lysosome, kuma ?arancin magnesium yana haifar da tarin sunadaran da ba su da kyau.

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Rushewar fahimtar abinci mai gina jiki: Insulin / IGF-1 da sauran hanyoyin sigina suna fahimtar yanayin sinadirai na salula kuma suna daidaita metabolism. Magnesium shine cofactor na masu kar?ar insulin da kinase na ?asa, kuma ?arancin magnesium yana haifar da juriya na insulin.

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Rashin aiki na Mitochondrial: Mitochondria masana'antun makamashi ne na salula, kuma DNA da sar?o?in numfashi suna da rauni ga lalacewa. Magnesium shine na biyu mafi yawan cation a cikin mitochondria, wanda ke da hannu a cikin ha?in ATP da antioxidant, kuma rashi na magnesium yana kara lalacewar mitochondrial.

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Senescence na salon salula: sel masu hankali suna daina rarrabuwa, ?oye abubuwan kumburi, kuma suna lalata microenvironment na nama. Magnesium na iya hana sake zagayowar tantanin halitta toshe sunadaran p53 da p21 da jinkirta jinkirin sel.

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Ragewar cell cell: Kwayoyin karawa suna da alhakin farfadowa da gyara nama, kuma lambar su da aikin su suna raguwa tare da shekaru. Magnesium yana rinjayar bambance-bambancen kwayar halitta na hematopoietic, kuma rashi na magnesium na iya hanzarta raguwar kwayoyin halitta.

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Canje-canje a cikin sadarwar salula: cytokines, hormones, da dai sauransu. Tsufa yana ?ara ?oye abubuwan kumburi. Magnesium yana hana kumburi kuma yana inganta sadarwar salula.

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Rashin Lafiyar Jiki: Autophagy hanya ce mai mahimmanci ga sel don rage lalata sunadarai da gabobin jiki. Magnesium yana kula da aikin autophagy ta hanyar daidaita ayyukan kwayoyin da ke da alaka da autophagy da kinases.

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Ciwon flora na hanji: flora na hanji yana da hannu a cikin metabolism na gina jiki da tsarin rigakafi, kuma rashin daidaituwa na microbial yana da ala?a da tsufa. Magnesium yana sarrafa flora na hanji kuma yana inganta lafiyar masauki.

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Kumburi na yau da kullun: tsufa yana tare da kumburi mara ?arancin ?ima a cikin jiki, wato, “tsufa mai kumburi”. Rashin ?arancin Magnesium yana haifar da kunnawa da yawa na hanyoyin siginar kumburi kamar NF-κB kuma yana ha?aka amsawar kumburi.

Bisa ga yawancin nazarin cututtukan cututtuka da gwaje-gwajen da bazuwar bazuwar, ?ara yawan abincin magnesium na abinci da kuma ?arin shirye-shiryen magnesium na iya rage shekarun da suka shafi kumburi na kullum, juriya na insulin, cututtuka na zuciya da jijiyoyin jini, da dai sauransu. Ko da yake babu wata shaida ta kai tsaye don tabbatar da cewa magnesium na iya tsawaita rayuwa, shaidun kai tsaye sun nuna cewa karin magnesium yana taimakawa wajen tsufa.

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Ko da yake magnesium yana da lafiya sosai, mutanen da ke fama da gazawar koda ya kamata su yi taka tsantsan, kuma yawan maganin baka na iya haifar da gudawa. Manya ya kamata su ba da fifikon samun isasshen magnesium daga abincin su, kamar kayan lambu masu ganye, duk hatsi, goro, da sauransu. Idan ya cancanta, bi shawarar likita don ?ara magnesium, kuma a kai a kai kula da ?wayar magnesium a cikin jini.

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Cikakken shaidar gwaji da bayanan asibiti:

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Shaidar gwaji na magnesium da kwanciyar hankali na kwayoyin halitta DNA shine kwayoyin halitta na rayuwa, kuma kwanciyar hankalinsa shine tushen aikin al'ada na sel. Binciken ya gano cewa akwai ions na magnesium tsakanin kusan kashi 50% na nau'i-nau'i na tushe a cikin tsarin DNA guda biyu na helix, wanda ke taka rawa wajen daidaita tsarin. A cikin kwayoyin halitta irin su Escherichia coli da yisti, ?ananan yanayin magnesium yana haifar da karuwa mai yawa a cikin kuskuren kwafin DNA. Gwaje-gwajen al'adun fibroblast na ?an adam kuma sun tabbatar da cewa ?arancin magnesium na iya haifar da gajeriyar gajeriyar telomere da ha?aka-kayyade bayanin cutarwar DNA. Gwaje-gwajen dabba sun nuna cewa tsarin kare kariya na antioxidant ya lalace a cikin hanta na hanta na berayen magnesium, kuma matakin 8-hydroxy-deoxyguanosine, alamar lalacewar DNA oxidative, ya karu. Wani bincike a cikin beraye ya gano cewa shan ruwa mai arzikin magnesium yana tsawaita tsawon telomere kuma ya rage lalata DNA. Wadannan sakamakon sun nuna cewa magnesium yana da mahimmanci don kiyaye zaman lafiyar kwayoyin halitta.

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A cikin nazarin yawan jama'a, matakan jini ko erythrocyte magnesium sun kasance suna da ala?a da rashin daidaituwa tare da alamomi daban-daban na rashin zaman lafiyar kwayoyin halitta, irin su micronucleus mita, matakan lalacewar DNA 8-hydroxy-deoxyguanosine, da kuma tsawon telomere. Binciken da aka yi na kusan kusan 200 manya masu lafiya sun gano cewa wa?anda ke da mafi ?as?anci matakan magnesium na jan jini suna da tsayin lymphocyte telomere na gefe wanda ya kasance, a matsakaici, 11.5% ya fi guntu fiye da wa?anda ke da matakan magnesium mafi girma. Wani bincike na ?ungiyar 1800 masu matsakaici da tsofaffi masu shekaru 45-74 shekaru da suka biyo baya na shekaru 5 sun gano cewa cin abinci na magnesium na abinci yana da ala?a da mummunar lalacewar DNA a cikin ?wayoyin lymphocytes na jini a cikin asali, kuma kowane karuwa a cikin ci gaban magnesium na 100mg / rana ya rage girman lalacewar DNA da 5.5% bayan shekaru 5. Wannan yana nuna cewa ?arar magnesium a cikin ?an adam na iya taimakawa wajen kiyaye kwanciyar hankali.

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Na biyu, ala?ar da ke tsakanin aikin magnesium da telomerase da tsufa na tantanin halitta Telomeres sune sifofi na musamman a ?arshen chromosomes, wanda ya ?unshi maimaitawar TTAGGG da furotin mai ?aure telomere, wa?anda ke kare chromosomes daga lalacewa a lokacin rarraba tantanin halitta. Amma a cikin sel ?an adam, tsayin telomere yana raguwa da 50 zuwa 100 tushe nau'i-nau'i a kowane yanki, kuma lokacin da gajarta ya kai ga ?ima mai mahimmanci, tantanin halitta ya shiga yanayin jin dadi. Telomerase shine ribonucleoprotease wanda ke tsawaita jerin telomere, amma yawanci ba a bayyana shi ba ko kuma ba a bayyana shi a cikin sel balagagge.

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A cikin linzamin kwamfuta fibroblasts embryonic (MEF), ?ananan matsakaicin magnesium ya rage yawan ayyukan telomerase fiye da 50% kuma ya nuna fasalin salon salula, irin su ?ara yawan ayyukan β-galactosidase da ha?akar maganganu na masu hana sake zagayowar tantanin halitta p16 da p21. Wadannan phenotypes na tsufa za a iya juyawa bayan jiyya tare da masu kunnawa na magnesium ko telomerase. An lura da irin wannan sakamakon a cikin kwayoyin halitta na endothelial na mutum da fibroblasts. Nazarin tsarin kwayoyin halitta sun gano cewa magnesium na iya daidaita tsawon telomere ta hanyar rinjayar magana da kuma gano wasu mahimman sunadaran a cikin hadaddun telomere, irin su TRF1 da TRF2. Bugu da ?ari, magnesium na iya kunna hanyoyin sigina irin su AKT da ERK, da kuma hana masu hana sake zagayowar tantanin halitta kamar p53 da Rb, don haka jinkirta tsufa na salula.

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Nazarin asibiti kuma yana goyan bayan hanyar ha?in gwiwa tsakanin magnesium da senescence na salula. A cikin fiye da 100 tsofaffi masu lafiya, matakan magnesium na jini sun kasance daidai da dangantaka da T lymphocyte yaduwa da kuma mummunan dangantaka da matakan p16 na plasma. Wani binciken ya hada da tsofaffi na 250 a cikin al'umma, kuma ya gano cewa matakan maganin magnesium na asali suna da ala?a da sauye-sauye a cikin alamun tsufa na ilimin lissafi irin su ji kofa, ?arfin kamawa, da kuma saurin tafiya, yana nuna cewa matsayin magnesium na iya rinjayar tsarin tsufa na gaba ?aya a cikin jiki. Wani binciken da aka yi na fiye da mutane 2,000 da ke da shekaru 70 idan aka kwatanta da nau'o'in maganin magnesium daban-daban tare da hadarin shekaru 10 na mutuwa kuma sun gano cewa rukunin da ke da ?ananan matakan magnesium yana da sau 2.2 mafi girma na mutuwa fiye da rukunin da ke da matakan mafi girma. Kodayake wa?annan nazarin binciken ba za su iya tabbatar da dalili da tasiri kai tsaye ba, suna tallafawa ?ungiya mai ?arfi tsakanin magnesium da tsufa daga hangen nesa na yawan jama'a.

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Matsayin magnesium a cikin hanyar siginar insulin Insulin shine ginshi?an tsarin hormone na homeostasis na glucose na jini na ?an adam. Bayan insulin ya ?aure ga mai kar?ar sa, yana haifar da kai-phosphorylation na mai kar?a, kuma yana kunna jerin kinases na furotin na ?asa kamar PI3K da AKT, kuma a ?arshe yana daidaita maganganun kwayoyin halittar da ke da ala?a da metabolism na glucose. Gwaje-gwaje da yawa sun nuna cewa magnesium yana taka muhimmiyar rawa a kusan kowane mataki na siginar insulin. 1. A cikin sel beta na tsibirin, magnesium yana samar da hadaddun MgATP tare da ATP don shiga cikin dukkanin tsarin aikin insulin, aiki da ?oyewa. A cikin layin sel beta na linzamin kwamfuta da beta, matsakaicin matsakaicin magnesium ya rage yawan samar da insulin da ke motsa glucose da fiye da 70%. 2. A cikin ?wayoyin insulin da aka yi niyya, aikin tyrosine kinase na masu kar?ar insulin ya dogara da ions na magnesium, kuma rashi na magnesium yana haifar da insulin phosphorylation mai kar?a da kuma ?addamar da sigina na ?asa, wanda ya haifar da juriya na insulin. A cikin 3T3-L1 adipocytes da L6 skeletal tsoka Kwayoyin, ?ananan-magnesium matsakaici ya rage yawan insulin-stimulated glucose da 40% zuwa 60%. 3. Magnesium kuma yana shiga cikin ?ayyadaddun hankali na insulin ta hanyar hana furotin phosphatase, daidaita maganganun integrin, yana shafar ayyukan jigilar GLUT4 da sauran hanyoyin. Wasu gwaje-gwajen dabba sun nuna cewa matsakaicin abincin magnesium na abinci yana inganta juriya na insulin a cikin kiba da nau'in berayen masu ciwon sukari na 2.

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Har ila yau, nazarin ilimin cututtukan cututtuka yana goyan bayan dangantaka ta kusa tsakanin magnesium da glucose metabolism. Nazarin lafiya na ma'aikatan jinya na Amurka, wanda ya ha?a da mata kusan 70,000 sama da shekaru 45 da suka biyo baya sama da shekaru 20, sun gano cewa wa?anda ke cikin mafi girman quntile na cin abinci na magnesium suna da ?arancin ha?arin ha?aka nau'in ciwon sukari na 2 da kashi 27 cikin 100 fiye da wa?anda ke cikin mafi ?as?anci quintile. Wani bincike-bincike na nazarin ?ungiyoyi 25 wanda ya ?unshi kusan mahalarta miliyan 1 ya nuna cewa kowace 100mg / rana karuwa a cikin abincin magnesium na abinci yana da ala?a da raguwar 8% zuwa 13% a cikin ha?arin nau'in ciwon sukari na 2. A cikin mutanen da ke da ciwon sukari, raguwar matakan magnesium na jini shima yana da ala?a da ci gaban cuta da rikitarwa. Wani bincike da aka yi kan majiyyata fiye da 300 masu fama da ciwon sukari na 2 ya gano cewa sinadarin magnesium ya ragu sosai a cikin masu fama da cututtukan zuciya fiye da na masu ciwon sukari kadai. A ?arshe, yawancin binciken da aka yi sun nuna cewa karin magnesium na iya jinkirta tsufa ta hanyar inganta juriya na insulin.

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4. Rashin Magnesium da rashin aiki na mitochondrial Mitochondria sune manyan wuraren samar da makamashin salula da kuma samar da nau'in oxygen mai amsawa (ROS). A lokacin tsarin tsufa, ingancin sarkar jigilar lantarki na mitochondrial yana raguwa kuma samar da ROS yana ?aruwa, yana haifar da maye gurbin mtDNA, membrane lipid peroxidation da sauran lalacewa, haifar da mummunan zagayowar da ha?aka tsufa ta tantanin halitta. Nazarin ya gano cewa kashi ?aya bisa uku na magnesium a cikin jiki an adana shi a cikin mitochondria, wanda ke da mahimmanci don kiyaye tsarin mitochondrial da aiki. A cikin mitochondria hanta na linzamin kwamfuta, tara daga cikin sassan 13 na adenosine triphosphatase suna bu?atar magnesium a matsayin cofactor. A cikin linzamin kwamfuta na mitochondria, ?ananan magnesium na iya rage yawan ayyukan enzymes masu mahimmanci a cikin zagayowar tricarboxylic acid, kamar isocitrate dehydrogenase da α-ketoglutarate dehydrogenase. A cikin mitochondria hanta na bera, rashi na magnesium zai iya rage yawan ha?in ATP da fiye da 60%, rage yawan kula da numfashi, da kuma ?ara yawan samar da ROS, wanda ya haifar da karuwar mtDNA da lalacewa da kuma maye gurbin. Kariyar Magnesium na iya juyar da wa?annan rashin aikin mitochondrial. A cikin ?wayoyin jijiyar ?wayar jikin mutum da cardiomyocytes, ?ananan magnesium na iya ?addamar da yuwuwar yuwuwar mitochondrial, haifar da bu?ewar mitochondrial permeability transivation pore (mPTP), haifar da sakin cytochrome C, kuma ?arshe haifar da apoptosis. A cikin ?wayoyin jijiyar ?wayar jikin mutum, ?ananan magnesium yana haifar da adadi mai yawa na ROS na mitochondrial ta hanyar kunna furotin kinase C, wanda ke haifar da rashin aiki na endothelial. Nazarin fiye da 100 marasa lafiya tare da ciwo na rayuwa sun gano cewa matakan magnesium na jini suna da ala?a da ha?in gwiwa tare da aikin numfashi na mitochondrial kuma suna da ala?a da rashin daidaituwa tare da matakan ROS na mitochondrial. A ta?aice, shaidun da ke sama sun nuna cewa magnesium wani muhimmin al'amari ne na kiyaye mitochondrial homeostasis, kuma rashin aikin mitochondrial yana daya daga cikin mahimman hanyoyin tsufa.

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Na biyar, aikin tsari na magnesium akan ?umburi na yau da kullun da tsufa na rigakafi na ?a??arfan ?arancin ?ima wani muhimmin fasalin tsufa ne. Nazarin ya gano cewa matakan abubuwan da ke haifar da kumburi irin su IL-6 da TNF-α a cikin mutanen da suka tsufa suna karuwa sosai, yayin da matakan cytokines na anti-inflammatory irin su IL-10 sun ragu, kuma wa?annan jihohi masu kumburi da ke haifar da tsufa ana kiran su da "flammaging". Tsufa mai kumburi na iya haifar da lalacewar nama da rashin daidaituwa na rigakafi, wanda shine tushen cututtukan cututtukan cututtukan da yawa. Nazarin gwaji ya nuna cewa rashi na magnesium na iya haifar da amsawar kumburi da rashin aikin rigakafi. A cikin al'adun macrophage na linzamin kwamfuta, ?ananan magnesium na iya daidaita ayyukan NF-κB da inganta sakin abubuwa masu kumburi daban-daban. A cikin sel epithelial na berayen bronchial na berayen, za'a iya ha?aka ?oyewar IL-6 da IL-8 ta sau 2 zuwa 3 ta hanyar ha?akar LPS a ?ar?ashin yanayin ?arancin magnesium. A cikin sel endothelial na ?an adam, ?ananan magnesium na iya kunna hanyar siginar p38 MAPK, haifar da maganganun ?wayoyin ?wayoyin cuta na intercellular don daidaitawa, kuma suna ha?aka amsawar kumburi. A cikin rashi na magnesium, matakan TNF-α, CRP da interleukin a cikin wurare dabam dabam da kyallen takarda sun karu sosai, gabobin jikin jiki sun kasance atrophy, adadin da aikin T da B lymphocytes sun ragu, kuma an kara yawan rigakafi. Magnesium supplementation na iya yadda ya kamata sau?a?a wa?annan cututtukan kumburi da na rigakafi. Nazarin asibiti kuma sun gano cewa ?arancin magnesium yana da ala?a da kumburi na yau da kullun. Nazarin sashe na giciye na sama da manya 5,000 a cikin Amurka sun gano cewa maida hankali ne mai rauni sosai tare da crp da kuma 40 a cikin mafi ?as?anci na matakan magnesium sun kasance 60% fiye da wa?anda ke cikin mafi girman matakai. Ha?in kai ya ma fi ?arfi a cikin mutane masu kiba. Wani binciken na mutane 3,200 da suka wuce shekaru 65 sun gano cewa matakan magnesium na jini suna da ala?a da ha?in gwiwa tare da tsayin telomere na farin jini da kuma mummunan dangantaka da matakan CRP da D-dimer. Meta-bincike na 25 gwaje-gwajen da aka bazu tare da jimlar girman samfurin fiye da mutane 2,000 ya nuna cewa ?arar magnesium na baka ya rage matakan CRP na jini da matsakaicin 22%, TNF-α ta 15%, da IL-6 ta 18%. Sabili da haka, ha?akar magnesium na iya jinkirta tsufa na jiki ta hanyar maganin kumburi.

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Dangantakar daidaitawa tsakanin magnesium da autophagy Autophagy wata hanya ce mai mahimmanci don lalata tantanin halitta da kuma kawar da sunadarai da ?wayoyin cuta da suka lalace, kuma yana da mahimmanci don kiyaye homeostasis na yanayin salon salula. Nazarin ya nuna cewa aikin autophagy yana raguwa a hankali yayin tsufa, kuma lahani a cikin autophagy na iya haifar da ha?akar furotin, rashin aikin mitochondrial, da dai sauransu, da kuma hanzarta tsufa na cell. Magnesium, a matsayin manzo na biyu, yana da hannu wajen daidaita tsarin farawa da tsarin autophagy. A cikin yisti, ?arancin magnesium yana hana bayyanar cututtukan da ke da ala?a da autophagy Atg1 da Atg13 ta hanyar kunna hanyar siginar TORC1. A cikin sel masu shayarwa, ?ananan yanayin magnesium na iya hana ayyukan ULK1, Beclin1 da sauran autophagy farawa sunadaran, da kuma toshe samuwar autophagosomes. A cikin ?wayoyin koda na ?an adam, ma'adinin chelating na magnesium ion EDTA na iya hana kwararar autophagy. Gwaje-gwajen in vitro sun nuna cewa ?ididdigar ilimin lissafin jiki na ions na magnesium na iya ?aure kai tsaye da kunna Atg4, wani enzyme proteolytic da ake bu?ata don maturation na autophagosome. Har ila yau, nazarin dabbobi ya gano cewa matsakaicin abincin da ake ci na magnesium zai iya rage cututtuka na autophagy a cikin neurons da cardiomyocytes, inganta aikin fahimi da aikin systolic na zuciya. Ko da yake akwai rashin shaidar asibiti kai tsaye, wasu nazarin binciken sun nuna ala?a tsakanin magnesium da autophagy. Matakan Magnesium sun kasance daidai da ala?a tare da bayanin alamun autophagy Atg5 da Beclin1 a cikin nama na kwakwalwa da ?wayoyin jini mononuclear na marasa lafiya tare da cutar Alzheimer. A cikin marasa lafiya da ke da nau'in ciwon sukari na 2, ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar ?wayar cuta tana da ala?a da matakan maganganun autophagy LC3 da p62. A ?arshe, mai yiwuwa magnesium yana taka muhimmiyar rawa wajen tsayayya da tsufa ta hanyar daidaita tsarin autophagy. Amma takamaiman tsarinsa yana bu?atar ?arin nazari.

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7. Mu'amala tsakanin Magnesium da flora hanji Flora na hanji wani muhimmin "ga?ar jiki" ne a cikin jikin mutum, wanda ke taka rawar da ba za a iya maye gurbinsa ba a cikin metabolism na abinci mai gina jiki, tsarin rigakafi, neuroendocrine da sauran bangarori. Binciken kwanan nan ya gano cewa canje-canje a cikin tushen da aikin ?oyayyiyar ?wayar cuta ta Mekabiousta tana da ala?a da tsufa. Misali, adadin firmicutes da Bacteroides a cikin hanjin tsofaffi sun ragu sosai, yayin da adadin ?wayoyin cuta masu fa'ida kamar enterococcus da Staphylococcus ya karu. Wannan rashin daidaituwa na flora na iya haifar da lalacewa ga shingen hanji, inganta sakin abubuwan da ke haifar da kumburi, da kuma tsananta kumburi a cikin jiki duka.

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A matsayin mahimmin kayan abinci mai gina jiki a cikin hanji, magnesium na iya rinjayar abun da ke cikin flora ta hanyoyi daban-daban. A cikin berayen da ba su da ?wayoyin cuta, shan ruwa mai arzikin magnesium na iya ?ara yawan ?wayoyin cuta masu amfani kamar su bifidobacterium da Bacteroides, da rage ?imar pH na hanji. A cikin nau'in linzamin kwamfuta na colitis, ?arin magnesium yana rage damuwa na furen hanji da hana NF-κB kunnawa a cikin hanyar siginar kumburi. A cikin gwaje-gwajen lafiyar ?an adam, rabon bifidobacteria a cikin najasa ya karu bayan makonni 8 na ?arin magnesium, kuma matakan lipopolysaccharide, D-lactic acid da sauran ?wayoyin cuta sun ragu. Wasu bincike na gaskiya sun kuma gano cewa rashi na magnesium na iya rushe ?un?un hanji, ?ara ha?akawa, da kuma haifar da yanayi don canzawa na endotoxins na enterogenic.

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Magnesium kuma na iya shafar tsarin tsufa na mai gida ta hanyar daidaita yanayin ?wayoyin cuta. Misali, magnesium yana motsa samar da sinadarai masu gajeriyar sarka kamar Bifidobacterium, wanda ke kunna G-protein-coupled receptor GPR43, wanda ke hana kumburi mai ala?a da kiba da juriya na insulin. Bugu da ?ari, magnesium kuma na iya rinjayar bile acid da tryptophan metabolism, kuma rikice-rikice na wa?annan hanyoyi guda biyu suna da ala?a da tsufa da cututtukan neurodegenerative. A ?arshe, ana sa ran magnesium ya zama sabon dabarun jinkirta tsufa ta hanyar sake fasalin flora na hanji da kuma daidaita tsarin kwayoyin-gut-brain axis, amma tasirinsa na dogon lokaci yana bu?atar tabbatarwa ta hanyar nazarin ?ungiyoyi masu zuwa.

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A ta?aice, adadi mai yawa na gwaji da shaida na annoba sun nuna cewa magnesium wani muhimmin sinadari ne don tsayayya da tsufa da inganta lafiyar jiki da tsawon rai. Yana da hannu cikin ?ayyadaddun tsarin tsufa ta hanyoyi masu zuwa:

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Ko da yake tasirin karin magnesium a kan rayuwar ?an adam a halin yanzu ba shi da mahimmanci, shaidun kai tsaye sun nuna cewa magnesium na iya taimakawa jinkirta tsufa da yawa da kuma inganta tsammanin lafiya. A nan gaba, ana bu?atar nazarin ?ungiyoyi masu zuwa da gwaje-gwajen da bazuwar bazuwar don ?ara fayyace tasirin maganin tsufa na magnesium da tasirin tasirin sa, don samar da shaidar tushen shaida don ?ir?irar dabarun ha?aka magnesium. Bugu da kari, yanayin abinci mai gina jiki na magnesium da bukatun al'ummomi daban-daban ba iri daya bane, don haka tsara tsarin kariyar magnesium guda daya shima matsala ce ta gaggawa da za'a warware. An yi imani da cewa tare da ci gaban tsufa magani da abinci mai gina jiki, za mu ?arshe fallasa duk asirai na wannan sihiri kashi magnesium, da kuma amfani da shi don yaki da tsufa da kuma gane mafarkin lafiya tsawon rai.

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