A cikin ‘yan shekarun nan, azumi ya zama sabon abin da masana kimiyya suka fi so, an nuna cewa azumi yana rage kiba da kuma tsawaita rayuwar dabbobi, hasali ma, yawan bincike ya nuna cewa azumi yana da fa’idojin kiwon lafiya da yawa, da inganta lafiyar jiki, da yin rigakafi ko jinkirta cututtukan da ke zuwa tare da tsufa, da ma rage saurin ci gaban ciwace-ciwace.
An nuna azumi na wucin gadi, kamar ?untatawa na caloric, don tsawaita tsawon rayuwa da lafiyar lafiyar dabbobin samfur irin su yisti, nematodes, kwari na 'ya'yan itace, da mice. A cikin mutane, azumi na tsaka-tsaki da na dogon lokaci, da kuma ci gaba da ?untatawa na caloric, suna da tasiri mai kyau a kan ma'auni na kiwon lafiya da yawa wanda zai iya samun tsarin aikin injiniya na yau da kullum, kuma akwai shaida mai karfi cewa autophagy yana daidaita wadannan tasirin.

Bugu da ?ari, spermidine (SPD) an ha?a shi da ha?akar autophagy, anti-tsufa, da rage yawan cututtukan zuciya da jijiyoyin jini a cikin nau'in nau'i.

A ranar 8 ga Agusta, 2024, Masu bincike daga Jami'ar Graz a Ostiriya, Sorbonne a Paris da Jami'ar Crete a Girka sun buga takarda mai suna "Spermidine yana da mahimmanci don yin sulhu a kai a kai" a cikin mujallar Nature Cell Biology da kuma tsawon rai "takardar bincike.

Nazarin ya nuna cewa spermidine ya zama dole don daidaitawa da sauri da kuma tsawon rai, da kuma inganta rayuwar rayuwa da tsawon lafiyar jiki ta hanyar azumi a cikin nau'o'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i) ya dogara da gyare-gyaren eIF5A-hypusination na spermidine da kuma ?addamar da autophagy na gaba.

A cikin dabbobi masu shayarwa, raguwar shekarun da suka shafi autophagy juzu'i yana ha?aka tarin tarin furotin da ?wayoyin cuta marasa aiki, da kuma gazawar kawar da ?wayoyin cuta da ?ara kumburi.

Hana autophagy a matakin kwayoyin halitta ya hanzarta tsarin tsufa a cikin mice. Asarar maye gurbi na aiki a cikin kwayoyin halittar da ke daidaitawa ko yin aikin autophagy an danganta shi da cututtukan zuciya, cututtukan cututtukan zuciya, cututtukan neurodegenerative, da cututtukan rayuwa, musculoskeletal, ido, da cututtukan huhu, wa?anda yawancinsu suna kama da tsufa. Sabanin haka, motsa jiki na autophagy a matakin kwayoyin halitta yana inganta tsawon rai da lafiya a cikin dabbobin samfurin, ciki har da 'ya'yan itace da kwari.

Baya ga abubuwan da suka shafi abinci mai gina jiki, amfani da polyamine spermidine na halitta akan dabbobin samfuri kamar yisti, nematodes, ?udaje masu ya'yan itace, da beraye wata dabara ce ta tsawaita rayuwa ta hanyar dogaro da kai. Bugu da ?ari, spermidine na iya mayar da motsi na autophagy a cikin ?wayoyin lymphocytes masu yadawa a cikin tsofaffi, wanda ya dace da lura cewa karuwar yawan abincin da ake ci yana hade da rage yawan mace-mace a cikin mutane.

Spermidine wani nau'in polyamine ne na halitta wanda ya wanzu a cikin kwayoyin halitta. A cikin 'yan shekarun nan, ?arin bincike sun nuna cewa spermidine yana da sihiri da kuma tasiri na rigakafin tsufa.

Don haka, azumi, ?untatawa caloric, da spermidine suna tsawaita tsawon rayuwar dabbobin ?ira kuma suna kunna tasirin kariya ta phylogenetically, dogaro da autophagy a cikin tsufa. A cikin wannan sabon binciken, ?ungiyar binciken ta ?ara bincika ko illolin kare lafiyar geriatric na azumin lokaci-lokaci yana da ala?a ko kuma ya dogara da spermidine.

Binciken ya gano cewa matakan spermidine ya karu a cikin yisti, kuda, ?uda, beraye da mutane a ?ar?ashin tsarin ?untatawa na azumi ko caloric daban-daban. Kwayoyin Halitta ko magungunan da ke toshe ha?in ha?in spermidine na endogenous suna rage saurin haifar da autophagy a cikin yisti, nematodes, da ?wayoyin ?an adam.

Bugu da kari, tsoma baki tare da hanyar polyamine a cikin jiki na iya kawar da tsawaita tasirin azumi akan tsawon rai da lafiya, da kuma tasirin kariya na azumi akan zuciya da cututtukan cututtukan fata.

A inji, spermidine yana daidaita wa?annan tasirin ta hanyar haifar da autophagy da hypusination na eukaryotic initiation factor eIF5A. Matsakaicin polyamine-Hypusination cibiya ce ta hanyar phylogenetically kiyaye lafiyar rayuwa a cikin ha?akar ha?akar autophagy da sauri-sakaci da ha?aka rayuwa.

Gaba?aya, binciken ya nuna cewa ha?akar azumi a kan tsawon rai da yanayin rayuwa a cikin mahimmin jinsuna da kuma dogaro da gyaran kafa na Eiif5a-hypusation na Eiif5a na Autophy.