1. Core tsarin

Kwayoyin metabolite glioxylate da aka yi niyya

Kwayoyin da ke da maganin miyagun ?wayoyi suna daidaita bayanin glyoxylate a cikin mahalli na rashin abinci mai gina jiki, wanda ke sake fasalin fasalin epigenetic mai masaukin baki, yana raunana amsawar rigakafi, kuma yana taimaka wa kwayoyin cuta su tsira a ?ar?ashin matsa lamba na ?wayoyin cuta ta hanyar hana aikin DNA demethylase (TET2) a cikin kwayoyin halitta.

Vitamin C yana kunna aikin enzyme TET2

Vitamin C, a matsayin mai kunnawa na halitta na TET2, zai iya magance tasirin hanawa na glyoxylate akan garkuwar rundunar, mayar da aikin demethylation na DNA, kuma ya sake farawa tsarin tsaro.

Rushe dabarun "mutuwar ?arya" na kwayoyin cuta

Acetaldehyde a lokaci guda yana kunna tsarin kare kai na ?wayoyin cuta, yana samar da masu dagewa don guje wa kashe ?wayoyin cuta. Vitamin C hade da maganin rigakafi zai iya karya wannan daidaitawar rayuwa kuma yana rage nauyin kwayoyin cuta.

2. Shaidar gwaji

Ingancin samfurin dabba: A cikin samfurin kamuwa da linzamin kwamfuta, ha?in bitamin C da maganin rigakafi ya karu da adadin rayuwa da kashi 60%, rage nauyin ?wayoyin cuta a cikin kyallen takarda da kashi 80%, da rage matakan abubuwan kumburi da kashi 50%.

Tasirin Ha?in kai: Vitamin C yana ha?aka hanyar siginar interferon (IFN), yana ?arfafa ikon garkuwar jiki don kawar da ?wayoyin cuta masu jure wa miyagun ?wayoyi, kuma yana hana STAT1 dephosphorylation, yana tsawaita amsawar rigakafin ?wayar cuta.

3. Clinical aikace-aikace m

Cin nasara kan matsalar juriya na miyagun ?wayoyi: Wannan dabarar tana ba da sabon maganin da ba na rigakafi ba ya dogara da ?wayoyin cuta masu jure wa ?wayoyin cuta irin su Salmonella da tarin fuka na Mycobacterium, musamman ga marasa lafiya da ke da maimaita cututtuka ko maganin rigakafi marasa tasiri.

Tsarin jiyya mai Sau?a?e: Vitamin C, azaman abinci mai aminci da ?arancin farashi, ana iya amfani dashi a hade tare da maganin rigakafi da ke akwai don rage yawan ?wayar ?wayoyi da rage tasirin sakamako.

?imar kari na rigakafi: isassun abinci na micronutrients (kamar bitamin C) na iya rage ha?arin kamuwa da kwayar cutar a kaikaice ta hanyar kiyaye ma'aunin microbiota na gut.

4. Umarnin bincike na gaba

Bincika tasirin ha?in kai da mafi kyawun ha?a??en sashi na bitamin C tare da sauran maganin rigakafi kamar beta lactams da quinolones.

Yi la'akari da tasirin kariyar bitamin C na dogon lokaci akan juyin halittar ?wayoyin ?wayoyin cuta masu jure wa ?wayoyi.

Ha?aka novel magungunan kashe kwayoyin cuta wa?anda ke niyya ga axis glycoxylic acid-TET2