1.Bidirectional tsari na gina jiki metabolism

HMB ya cimma daidaito mai ?arfi na gyaran rauni na tsoka ta hanyar aiki tare da manyan hanyoyi masu yawa:

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Kunna siginar mTOR: ha?aka matakin ribosome S6 kinase phosphorylation ta 38%, ha?aka sarkar myosin mai nauyi da sauran ingantaccen ha?in furotin.

Sakamakon inhibitory na ha?akawa: rage yawan maganganun E3 ubiquitin ligase MuRF1 ta 41%, kuma ya katange tsarin tsarin kwayoyin halitta na rushewar tsoka.

? autophagy homeostasis : Inganta LC3-II / LC3-I rabo zuwa 1: 1.5 don hana tsoka fiber lalacewa lalacewa ta hanyar wuce kima autophagy ?

Na biyu, sabunta fasahar kariyar tantanin halitta

HMB yana ha?aka zaman lafiyar tantanin halitta ta hanyar matakan matakan ?wayoyin cuta:

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?arfafa tsarin membrane: ?ara abun ciki na phosphatidylinositol da 27%, inganta juriya ga matsalolin injiniya na ?wayar tsoka.

Tsarin Calcium ion: yana hana bu?ewa mara kyau na mitochondrial permeability pore mitochondrial kuma rage ha?arin ?wayar calcium ta 63%

Kariyar damuwa na oxidative: hanyar Nrf2 kunna, aikin superoxide dismutase (SOD) ya karu da 41%

Iii. Bayanan ?wa??wara na magungunan wasanni

1.High tsanani wasanni kariya

'Yan wasan ?wallon ?afa suna ?arawa da 3 g/rana HMB sun rage peak creatine kinase (CK) da 44% da rage tsawon lokacin ciwon tsoka da 51%

Bayan sa'o'i 72 na motsa jiki na centrifugal, abin da ya faru na rheology na layin Z-line na ?wayoyin tsoka ya ragu da kashi 62%, kuma an inganta tsarin tsarin mitochondria da 83%

2.Endurance inganta aikin

A cikin masu tseren marathon, matakan lactate na jini ya ragu da kashi 19% kuma ajiyar glycogen na tsoka ya karu da 27%?68

Sake zagayowar kari na mako 6 ya karu VO2max da 4.2% kuma ya karu juriyar motsa jiki da 13%

4.Clinical sauyin yanayi

5.Rigakafin da maganin ciwon tsokar tsoka

A cikin marasa lafiya na ICU da aka kara da HMB na kwanaki 28, an kiyaye kauri na quadriceps 1.3mm fiye da haka, kuma an sami nasarar nasarar kashe layin iska da kashi 31%.

A cikin masu fama da ?onawa mai tsanani, raguwar furotin ya ragu da kashi 47% kuma lokacin warkar da rauni ya fi guntu kwanaki 5 ?

2.Shigar da sarcopenia na tsofaffi

Bayan makonni 12 na shiga tsakani, saurin tafiyar tsofaffi masu shekaru sama da 70 ya karu da 0.15m/s, kuma ha?arin fa?uwa ya ragu da kashi 38%.

MRI ya nuna kashi 21% rage a cikin mai mai da ke ciki da kashi 14% a cikin nau'in fiber diji

5.Cutting-baki fasahar fasaha

Nano tsarin bayarwa

Liposome encapsulation fasaha ya karu tsoka manufa maida hankali da 3.7 sau, da kuma canji kudi na jini ya kasance

Faci mai kaifin baki yana cimma ka'idojin amsa EMG kuma yana rage jinkirin sakin zuwa da?i?a 15 ?

Nasarar a cikin ilimin halitta na roba

An ?ara yawan amfanin aikin injiniya zuwa 8.7g/L kuma an rage farashin samarwa da kashi 62%

Fasahar gyaran gyare-gyaren CRISPR tana ha?aka gyaran tsoka da kashi 41 cikin ?ari, yana shiga gwaji na musamman

6.Safety ?ayyadaddun bayanai

m guba : na baka LD50> 5000mg/kg a cikin berayen, shi ne ainihin ba mai guba ?

Aikace-aikace na dogon lokaci : Ba a lura da ciwon hanta ba bayan watanni 12 na sa baki, kuma abin da ya faru na rashin jin da?i na gastrointestinal shine

Matsakaicin adadin: ana ba da shawarar yawan motsa jiki don ?aukar 3 g / rana a cikin rabe-raben allurai, ana ha?aka kashi na warkewa ta hanyar matakai.

Vii. Gaban Outlook

Tsarin Epigenetic: Binciko tasirin HMB akan tsarin DNA methylation na ?wayoyin karan tsoka

Tsarin hul?ar al'umma na kwayan cuta: Ana nazarin rawar da ake gudanarwa na HMB metabolites akan intestinal firmicutes/Bacteroides ratio.