CiticolineAn yi amfani da shi sosai a cikin aikin asibiti, musamman don maganin cututtukan cututtuka da ke haifar da raunin craniocerebral ko ha?ari na cerebrovascular, kuma ya sami sababbin amfani a cikin aikin asibiti. Maganin sa a cikin zubar jini na kwakwalwa, cutar Parkinson, glaucoma, ciwon sukari na gefe neuropathy da tinnitus da sauran cututtuka su ma sun jawo hankali. Don haka menene citicoline, menene tasirin pharmacological, alamun sa (takamaiman jiyya na wa?anne cututtuka), inganci da aminci?

Citicoline ne guda nucleotide wanda ya hada da ribose, cytosine, pyrophosphate da choline. Yana da endogenous nucleotide na jikin mutum. Yana da hannu a yawancin mahimman hanyoyin rayuwa a cikin jiki. Yana da asali na halitta na phospholipid kira na neuron cell membrane tsarin da precursor na biosynthesis na neurotransmitter acetylcholine.

Citicoline wakili ne na neuroprotective wanda zai iya kare ?ananan ?wayoyin cuta, don haka ragewa ko hana ci gaban cuta. A halin yanzu, magungunan neuroprotective da aka saba amfani da su a cikin aikin asibiti sun ha?a da masu hana tashar calcium, masu adawa da glutamate, masu lalata radicals, da kuma cell membrane stabilizers, wanda citicoline ya kasance na cell membrane stabilizers.

Citicolineyana da tasirin magunguna masu yawa da yawa, kuma wa?annan hanyoyin aiwatar da aikin suna sa ya sami babban tasiri a cikin ha?akar neuroprotection da gyaran jijiyoyi. Yana da tasirin neuroprotection na toshe abin da ya faru na raunin neuronal da tasirin gyaran jijiyoyi bayan abin da ya faru na raunin neuronal, wanda ke fadada taga lokacin warkewa na citicoline.

Dangane da kaddarorin magungunan sa, ana amfani da citicoline sosai a cikin maganin bugun jini, raunin hankali, raunin kwakwalwa, cutar Parkinson, glaucoma, ciwon sukari na gefe neuropathy, tinnitus da sauran cututtuka, kuma an tabbatar da ingancinsa da amincinsa a cikin binciken asibiti da yawa, tare da isassun shaidun shaidar likita. Shanyewar jiki: shanyewar jiki wani nau'i ne na toshewar jijiyoyin jini ko fashewa, wanda ke haifar da lalacewar kwakwalwa na nau'ikan cututtuka, gami da ischemic da bugun jini, wanda bugun jini na ischemic shine babban nau'in bugun jini, wanda ya kai kashi 75% zuwa 90% na duk bugun jini. Ha?arin bugun jini na rayuwa a cikin al'ummarmu shine 35% -40.9%, matsayi na farko a duniya, ba wai kawai ba, bugun jini kuma shine farkon sanadin mutuwa da nakasa a mazaunan mu.

Shaidar binciken asibiti:

1. A cikin 2002, Jaridar American Journal Stroke ta buga wani bincike-bincike na gwaje-gwaje na asibiti a kan marasa lafiya da ke fama da bugun jini mai tsanani, wanda ya nuna cewa citicoline na baka ya kara yiwuwar ciwon bugun jini ya murmure bayan watanni 3 [1].

2. A cikin 2009, an gudanar da gwajin binciken bincike na miyagun ?wayoyi a Koriya ta Kudu don marasa lafiya 4191 da ke fama da ciwon ischemic mai tsanani, kuma sakamakon ya nuna cewa citicoline ya inganta darajar NIHSS da kuma BI na marasa lafiya tare da amfani a farkon da kuma marigayi magani, kuma amfanin aikace-aikacen dogon lokaci ya fi girma, kuma tasirin warkewa ya kasance daidai da dangantaka da kashi. Ha?akawa ya kasance mafi mahimmanci a cikin ?ungiyar masu girma (≧2000mg / rana), kuma aikace-aikacen dogon lokaci yana da aminci kuma an jure shi [2].

3. Sakamako na multicenter, bazuwar, makafi biyu, nazarin matukin jirgi mai sarrafa wuribo akan zubar da jini na kwakwalwa yana nuna cewa citicoline magani ne mai lafiya don maganin zubar da jini tare da ingantaccen sakamako na warkewa [3].

4. Wani bu?a??en lakabin, bazuwar, binciken layi daya ya kimanta tasirin citicoline akan raunin fahimi bayan bugun jini, kuma sakamakon ya nuna cewa amfani da citicoline na dogon lokaci yana inganta ha?akar fahimi bayan bugun jini [4].