Tsufa wani abu ne mai rikitarwa, matakai da yawa, tsari a hankali wanda ke faruwa a tsawon rayuwa. Da shigewar zamani, gabobi da tsokoki na jikin dan Adam za su tsufa sannu a hankali, wasu cututtuka kuma za su faru tare da girma, ciki har da ciwon daji, ciwon sukari, cututtukan zuciya da jijiyoyin jini da sauransu.

Nazarin da yawa sun nuna cewa phytochemicals, ciki har da polyphenols, flavonoids, terpenoids, da dai sauransu, na iya tsawaita rayuwa mai kyau ta hanyar anti-oxidation, kunna mitochondrial autophagy da sauran hanyoyin, kuma suna da kaddarorin anti-tsufa.

A baya can, masu binciken sun gano cewa cirewar sage na iya jinkirta tsufa a cikin gwaje-gwajen vitro, kuma a cikin linzamin kwamfuta da kuma samfurin mutum a cikin vitro, sage tsantsa ya rage yawan adadin kwayoyin beta-galactose sidase masu dacewa da shekaru masu kyau, suna nuna alamun tsufa.

Kwanan nan, Masu bincike a Jami'ar Padova a Italiya sun buga takarda a cikin mujallar Nature Aging mai suna "Targeting senescence jawo ta shekaru ko chemotherapy tare da polyphenol-arzikin. Na halitta tsantsa inganta tsawon rai da kuma kiwon lafiya tsawon a cikin mice."

Nazarin ya nuna cewa cin abinci na yau da kullum na sage tsantsa zai iya tsawaita tsawon rai da lafiyar lafiyar beraye, ya hana kumburi da ke haifar da shekaru, fibrosis da alamun tsufa a cikin nau'i-nau'i iri-iri, da inganta yanayin tsufa.

A cikin wannan binciken, masu binciken sunyi nazarin yiwuwar tsufa na sage tsantsa (HK) a cikin vivo ta hanyar ?irar linzamin kwamfuta, ta hanyar ?ara ?ananan allurai na HK zuwa ruwan sha na yau da kullum, da kuma nazarin tarin kwayoyin halitta a cikin nau'in linzamin kwamfuta, da ma'auni da yawa da suka shafi shekaru, ciki har da tsawon rai, lafiyar jiki, fibrosis, ma'adinan kashi, da kumburi.

Masu binciken sun baiwa beraye dan watanni 20 shan ruwan sha mai dauke da HK har sai sun mutu.

Sakamakon ya nuna cewa matsakaicin tsawon rayuwar beraye a cikin rukunin jiyya na HK shine watanni 32.25, yayin da matsakaicin tsawon rayuwar beraye a cikin rukunin kulawa ya kasance watanni 28 kawai. Maganin HK ya tsawaita tsawon rayuwar da watanni 4.25, kuma tsawon rayuwar berayen mata da na miji ya kasance mai mahimmanci.

Binciken ilimin tarihi game da fata, hanta, koda, da huhu na berayen sun gano cewa maganin HK bai haifar da canje-canje a cikin sigogi na hematopoietic ko guba na gabobin jiki ba, yana nuna cewa maganin HK yana da lafiya.

Bugu da ?ari, maganin HK ya inganta yanayin tsufa a cikin mice idan aka kwatanta da sarrafawa, ciki har da sassan hunchback, ci gaban ?ari, da matsayi na dabba.

Wadannan sakamakon sun nuna cewa maganin HK na iya tsawaita tsawon rayuwa mai kyau da kuma tsawon rai na mice, kuma ba a lura da guba ba.

?arin bincike ya gano cewa maganin HK ya inganta yanayin tsufa a cikin nau'i-nau'i iri-iri, ciki har da ingantaccen asarar gashi, kashi, lafiyar tsoka, da aikin koda.

Binciken injiniyoyi ya nuna cewa maganin HK yana da ?asa da ?ayyadaddun ?ayyadaddun tsarin tsufa na SAUL_SEN_MAYO, yayin da tsarin tsarin tsufa da aka tsara yana da ala?a da wuce gona da iri na kumburi, kunnawa na rigakafi, da kuma hanyoyin da suka shafi shekaru, yana ba da shawarar cewa maganin HK ya canza fasalin fassarar da ke da ala?a da kumburi da tsufa. Bugu da ?ari, nazarin tsokoki, fata, koda, da huhu sun gano cewa maganin HK ya rage matakan tsufa a cikin kyallen takarda daban-daban a cikin jiki.

Baya ga tsufa na dabi'a, masu binciken sun kuma gano cewa maganin HK na iya hana tsufa da cututtukan zuciya da ke haifar da doxorubicin na chemotherapy, yayin da yake kiyaye tasirinsa na warkewa.

A ?arshe, saboda HK wani tsantsa ne mai ?auke da nau'ikan kayan shuka iri-iri, masu binciken sun bincika takamaiman abubuwan da ke taka rawar hana tsufa, kuma sakamakon ya nuna cewa ?angaren flavonoid, luteolin (Lut), shine sinadari mai aiki na HK anti-tsufa, wanda ke inganta tsufa ta hanyar canza hul?ar tsakanin p16 da CDK6.

A hade tare, binciken ya sami wani tsantsa na halitta tare da tasirin tsufa wanda ya inganta tsufa na tantanin halitta da nama, ingantattun alamomin da suka shafi shekaru irin su Jawo, humpback, tara alamun tsufa da lalacewar DNA a cikin kyallen takarda, da mahimmancin tsawon rayuwar dabba.