SAIB (sucrose isobutyrate acetate) babban kayan aikin magunguna ne. Ruwa ne mai danko wanda aka shirya ta hanyar sarrafa esterification na sukari na halitta (sucrose) tare da acetic acid da isobutyric anhydride. Cakuda ne da aka samar ta hanyar distillation da samar da tsafta sosai. Ana iya amfani da shi azaman ?orewa kayan wakili na saki, ?arfi/danko da mai hana muggan ?wayoyi.

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Halayen samfurin SAIB

SAIB kyakkyawan ?arfi ne / mai ?aukar hoto don API na hydrophobic kuma yana da aikin sakin jinkirin.

SAIB ba ya kir?ira kuma ya kasance amorphous a dakin da zafin jiki, wanda ke inganta yawan isar da ?wayoyi akai-akai;

SAIB ba shi da polymeric kuma baya yin kwarin gwiwa ko hazo lokacin da ake mu'amala da ruwan jiki mai ruwa. SAIB yana narkewa a cikin kaushi na kwayoyin halitta da yawa kuma yana dacewa da abubuwa da yawa; Ana iya tarwatsa SAIB a cikin ruwa tare da taimakon kayan kaushi.

SAIB yana da kaddarorin bioadhesive kuma ana iya amfani da su don aikace-aikacen facin transdermal, sublingual da buccal.

Aikace-aikacen samfur

1. Jinkirin fitarwa

A cikin wannan adadi na sama, ana iya ganin cewa SAIB yana da darajar HLB kusan 5, wanda ke nuna cewa yana da hydrophobic.

2. Maganin rashin ?arfi na ruwa mara kyau

Hydrophobic SAIB shine mai kyau mai ?arfi / mai ?aukar hoto don API tare da ?arancin ruwa mara kyau, kuma amfani da SAIB yana inganta narkewar magunguna marasa narkewa.

3. Hana shan miyagun ?wayoyi

Amfani da SAIB yana ?ara girman barbashi na opioids yayin ni?a kuma yana tsoma baki tare da hakar ?wayoyi.

(1) Polymers (polyoxyethylene da / ko hydroxypropyl methylcellulose) da kuma tocopherol acetate sune granules da aka yi daga maganin barasa na SAIB. Ana rarraba shirye-shiryen a matsayin ko dai ba a warke / ba a warke ba ko kuma an warke / warkewa (an warke 90oC na mintuna 30).

(2) Pseudoephedrine hydrochloride, polymers (polyoxyethylene da / ko hydroxypropyl methylcellulose) da kuma tocopherol acetate sune granules da aka yi daga maganin barasa na SAIB. An rarraba shirye-shiryen a matsayin ko dai ba a warke / ba a warke ba ko kuma an warke / warkewa (an warke 90oC na minti 30).

?ididdigar cin zarafi na hanci ya nuna cewa amfani da SAIB ya karu da girman foda a lokacin ni?a, tare da har zuwa 47% na girman nika fiye da 1mm.

Idan aka kwatanta da ?ungiyar kulawa, adadin hakar SAIB a cikin ruwa, 0.1% N HCl da 0.1% N NaOH kaushi ya ragu da 41.3% -42.5%, 24.8% -26.1% da 37.4% -50.6%, bi da bi. Yin amfani da abubuwan kaushi na halitta don hakar yana haifar da tarkace masu ?an?ano wa?anda ke da wahalar wucewa ta hanyoyi daban-daban na gudanarwa (misali, allura, sha, snorting, da sauransu), hana shan miyagun ?wayoyi.

?arshe

Amfani da SAIB, ba tare da sutura ba, ana iya ha?a shi kai tsaye tare da API don tsawaita sakin miyagun ?wayoyi da samun ci gaba mai dorewa.

Hydrophobic SAIB, wanda za'a iya tarwatsawa a cikin ruwa tare da taimakon magungunan kwayoyin halitta, ana iya amfani dashi tare da hydrophobic ko hydrophilic apis; SAIB na iya inganta solubility na API tare da rashin ruwa mara kyau kuma yana da kyakkyawan ?arfi da mai ?auka don API tare da rashin ruwa mara kyau.

Amfani da SAIB yana hana shan miyagun ?wayoyi ta hanyar ?ara girman ?wayar ?wayar cuta lokacin da aka ni?a shi, yana tsoma baki tare da hako magunguna, da kuma yin wahalar shan maganin ta hanyoyi daban-daban na gudanarwa.

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