Nazarin farko ya nuna cewa bitamin C yana da fa'idodin kiwon lafiya iri-iri, gami da tsarin rigakafi, tasirin antioxidant, da lafiyar zuciya. Ko da yake bitamin C muhimmin sinadari ne don kiyaye lafiya, da yawa ko kadan na iya yin illa ga lafiya.

Melanoma (MM) cuta ce mai muni da ta samo asali daga sel masu launi na fata kuma ita ce nau'in ciwon daji mafi hatsarin fata, kodayake yana da ?arancin ha?ari kuma yana da ?arfi da ha?aka. Cutar sankarau tana karuwa a cikin ?an shekarun da suka gabata.

Kwanan nan, masu bincike daga Jami'ar Kudancin Florida da ke Amurka da Jami'ar Leicester a Burtaniya sun buga wata takarda mai suna "Redox modulation of oxidatively-induced DNA damage by ascorbate enhances" a cikin mujallar Free Radical Biology and Medicine duka a cikin vitro da ex-vivo DNA lalacewa samuwar da kuma mutuwar cell a cikin melanoma cell ".

Nazarin ya nuna cewa maganin ciwon daji na melanoma tare da bitamin C na iya ?ara lalacewar DNA da ke haifar da oxidant ga kwayoyin cutar kansa da kuma inganta mutuwar kwayar cutar kansa, kuma wannan lalacewa ya yi daidai da adadin melanin a cikin sel. Kuma ga ?wayoyin fata na al'ada, yana taka rawar kariya.

A cikin wannan binciken, masu binciken sun kafa rukuni na layin salula na MM tare da launi daban-daban, sun yi amfani da hydrogen peroxide a matsayin samfurin oxidant, kuma sun bincikar bitamin C don ?ara yiwuwar kashe kwayar cutar melanoma ta hanyar ha?aka lalacewar DNA da ke haifar da iskar oxygen.

Masu binciken sun gwada matakan bitamin C da ke haifar da lalacewar DNA a cikin layin salula guda biyar kuma sun gano cewa idan aka kwatanta da kwayoyin fata na al'ada, keratinocytes (HaCaT), matakan lalacewar DNA na ?arshe sun kasance mafi girma a cikin dukkanin kwayoyin MM, domin girman lalacewa: SK23 Kwayoyin tare da babban pigmentation, SK28 Kwayoyin tare da matsakaici pigmentation, A375P da kuma A375M pigmentation, yayin da ba tare da pigmentation Kwayoyin. Lalacewar DNA.

Bugu da kari, masu binciken sun yi nazari kan hankalin layukan tantanin halitta guda biyar don lalacewa ta hanyar oxidant (hydrogen peroxide) kuma sun gano cewa lalacewar lalacewa ga hydrogen peroxide ya yi daidai da abin da ke sama.

?arin bincike na nau'in oxidative na ciki na ciki ya nuna cewa kwayoyin MM sun nuna matakan da suka fi girma na nau'in nau'in oxidative na ciki fiye da kwayoyin HaCaT, kuma jerin sassan layi guda biyar sun kasance daidai da lalacewar DNA, lalata lalacewa, da cytopigmentation.

Bayan haka, masu binciken sun bi da ?wayoyin cuta tare da ko ba tare da bitamin C ba kuma sun bincika yuwuwar tasirin ka'idoji na bitamin C akan lalacewar DNA da ke haifar da iskar shaka da kuma kashe tantanin halitta.

Sakamakon ya nuna cewa ga dukkanin kwayoyin MM, matakin lalacewar DNA na endogenous da aka haifar da jiyya na bitamin C ya karu sosai, yayin da na HaCaT sel ba su da mahimmanci, kuma lalacewar DNA ta ?arshe ta kasance daidai da abin da ke sama.

Bugu da ?ari, matakin lalacewar nucleobase na bitamin C ya kasance mafi girma a cikin ?wayoyin SK23 masu launi (18.5%) kuma mafi ?as?anci a cikin ?wayoyin A375P marasa launi (14.2%).

Dangane da gaskiyar cewa bitamin C na iya ha?aka lalacewa ta hanyar peroxide da ke haifar da lalacewar DNA na endogenous da lalacewar nucleobase a cikin sel na MM, masu binciken sun kuma bincika tasirin bitamin C akan raguwar igiyoyin DNA guda biyu kuma sun gano cewa ga dukkan ?wayoyin MM, matakin DNA na ?arna biyun da aka jawo ta hanyar jiyya na bitamin C ya karu sosai, amma ba ga ?wayoyin HaCaT ba. Jerin layin tantanin halitta guda biyar har yanzu yana daidai da na sama.

Mahimmanci, masu binciken sun yi nazari akan ko bitamin C ya inganta mutuwar kwayar cutar MM, kuma sun gano cewa bitamin C ya inganta kashe-kashen peroxid na dukkanin kwayoyin MM, yayin da suke taka rawar kariya a cikin kwayoyin HaCaT, kuma jerin kisan sun kasance daidai da abin da ke sama.

A ?arshe, binciken ya kuma gano cewa bitamin C na iya ha?aka ingancin maganin melanoma na yanzu Elesclomol, yana ha?aka lalacewar DNA na ?wayoyin cutar kansa ta hanyar Elesclomol.

Masu binciken sun ce yin amfani da bitamin C, wanda zai iya haifar da lalacewar DNA a cikin kwayoyin cutar kansa da kuma haifar da mutuwar ciwon daji, na iya zama hanya mafi inganci don magance ciwon daji, wanda har yanzu yana bu?atar ?arin nazarin asibiti da gwaji don tabbatarwa.

Ganin cewa an yi nazarin bitamin C da kyau kuma an san cewa ana jurewa da kyau, masu binciken sun yi imanin cewa likitocin na iya amfani da bitamin C a matsayin kari don ha?aka jiyya da ake da su.

Idan aka ha?u, wannan binciken in vitro ya nuna hakanbitamin Cna iya ha?aka lalacewar DNA mai haifar da iskar shaka, ha?aka mutuwar ?wayar cutar kansa, yayin da ke taka rawar kariya a cikin ?wayoyin fata na yau da kullun, da ha?aka tasirin magungunan melanoma na yanzu, wanda ya cancanci ?arin bincike.