Sucralose shine madadin sukari. Abin zaki ne da ake amfani da shi sosai. Sau da yawa mutane kan yi la'akari da abubuwan maye gurbin sukari saboda suna ba da za?i amma ba su ?unshi abun cikin kalori da ke cikin sukarin tebur ba. Sucralose galibi ana amfani dashi azaman sinadari a cikin abinci da abubuwan sha, galibi ana tallatawa azaman "marasa sukari" ko "asara mai nauyi" don rage yawan adadin kuzari.

Menene sucralose?

Sucralose abu ne da ake amfani da shi sosai wanda ba shi da abinci mai gina jiki, mai zaki da sifili-kalori. Sucralose an ha?e shi ta hanyar wucin gadi daga sukarin tebur (sugar tebur) ta hanyar matakai da yawa wa?anda ke za?in maye gurbin rukunin hydroxyl uku a cikin ?wayar sukari tare da ?wayoyin chlorine guda uku. Daga baya, an tsarkake shi zuwa kusan 98%. Wa?annan gyare-gyaren sinadarai sun tabbatar da cewa sucralose ya fi sau 600 za?i fiye da sukarin tebur. ?arshen samfurin farar fata ne, crystalline, ingantaccen kayan zaki na wucin gadi wanda yake narkewa sosai a cikin ruwa. Babban narkewar Sucralose a cikin ruwa ya sa ya dace don ha?awa cikin abinci da aka sarrafa iri-iri: kayan gasa, abubuwan sha, cingam, gelatin, da daskararrun kayan zaki. Mutanen da ke neman madadin kayan zaki gaba?aya sun fi son sucralose zuwa sauran kayan zaki na wucin gadi kamar aspartame da saccharin. A matsayin abin da aka samu na sukarin tebur, sucralose yana ri?e da yawancin ?an?anon “sukari” da ya saba, yayin da ba shi da ?an?ano mai ?aci na gama gari ga sauran maye gurbin sukari. Za?i mai ?arfi na sucralose yana ba da ?aramin adadin don tafiya mai nisa, yana mai da shi mashahurin za?i don abinci mai ?arancin kalori. Shayewar sucralose a cikin sashin gastrointestinal yana da kadan, kuma babban hanyar fitar da sucralose ba ta canzawa a cikin stool. Saboda haka, babu wani tsari na catabolic (rushewa), yana tabbatar da cewa sucralose ba shine tushen makamashi da / ko adadin kuzari ba. Matsayin Amincewa da tsari sucralose an fara yarda da shi don amfani a Kanada a cikin 1991, sannan Ostiraliya a 1993 da New Zealand a 1996. A cikin 1998, Hukumar Abinci da Magunguna ta Amurka (FDA) ta amince da sucralose don amfani a cikin nau'ikan abinci da abin sha guda 15, kuma an fa?a?a amfani da shi azaman gama-gari-manufa don abinci mai zaki19. ?ari a cikin Tarayyar Turai a cikin 2004. FDA ta tsara sucralose azaman ?ari na abinci. ?ar?ashin Dokar Abinci, Magunguna, da Kayan kwalliya na tarayya, masu za?i dole ne su kasance lafiya don ci. ?ididdigar aminci na FDA ya dogara ne akan nazarin dabbobi masu yawa da gwaje-gwaje na asibiti wa?anda ke kimanta ilimin toxicology, teratogenicity (ikon haifar da rashin lafiyar tayin lokacin daukar ciki), da ciwon daji. Dangane da shawarwarin FDA, ?imar sucralose mai kar?a na yau da kullun (ADI) an saita shi a 5 mg / kg nauyin jiki kowace rana (mg/kg/ day). Yiwuwar fa'idodin amfani da sucralose don sarrafa nauyi mara nauyi

Ba kamar sukarin tebur ba, sucralose baya narkewa ko rushewa a cikin sashin gastrointestinal kuma baya aiki azaman mai mai caloric a jikinmu. Don haka Sucralose babban za?i ne ga mutanen da ke neman maye gurbin sukarin tebur (tekali 1 ko kusan gram 4.2 na sukarin tebur ya ?unshi adadin kuzari 16) kuma yana rage yawan adadin kuzari. Ta hanyar ha?a sucralose a cikin abincin su, mutane na iya biyan bu?atun su masu da?i ba tare da damuwa da ?arin adadin kuzari ba, wanda ke da mahimmanci don sarrafa nauyi.

Ya dace da sarrafa ciwon sukari

Sucralose ba ya ha?aka ta jikinmu don kuzari kuma baya haifar da ha?aka matakan sukari na jini (6). Dangane da binciken asibiti na sucralose a cikin mutanen da ke da ciwon sukari, FDA ta yanke shawarar cewa sucralose baya cutar da sarrafa sukarin jini na ?an gajeren lokaci a cikin mutanen da ke da nau'in ciwon sukari na 2. Bugu da ?ari, jerin nazarin asibiti sun nuna cewa sucralose baya shafar glucose homeostasis na dogon lokaci (kamar yadda aka auna ta HbA1c glycosylation) a cikin marasa lafiya da nau'in ciwon sukari na 2. Don haka, sucralose shine amintaccen za?i na za?i ga masu ciwon sukari wa?anda ke kula da rage cin abinci mara nauyi. Koyaya, kamar kowane za?i na abinci, mutanen da ke da ciwon sukari dole ne su tuntu?i likitan ha?in gwiwar su ko na aikin likitanci don tsarin abinci na ke?a??en yayin sa ido kan ha?arin hypoglycemia daga cin sucralose. Matsalolin lafiya masu yuwuwa da illolin ko da yake an sake nazarin sucralose don aminci ta hanyar masu kula da su, ana yin muhawara game da amincin sucralose da yuwuwar tasirin lafiyar sa. Musamman, nazarin toxicological da ke kimanta tasirin tsarin glucose, neurotoxicity, da carcinogenicity a cikin dabbobi sukan haifar da hasashe.

Nazarin ya nuna cewa kayan zaki na wucin gadi, gami da sucralose, suna motsa sigar insulin ta hanyar masu kar?a mai da?i da aka bayyana akan ?wayoyin beta a cikin pancreas, musamman idan babu glucose. Hakanan an nuna sucralose don haifar da ?oyewar GLP-1. GLP-1 yana da mahimmanci ga homeostasis na glucose kuma gaba?aya yana ha?aka siginin insulin na matsakaicin glucose. A tsawon lokaci, ?ara yawan matakan insulin a cikin jini bayan fallasa sucralose na iya haifar da juriya na insulin saboda raguwar ayyukan mai kar?a. Ragewar glucose homeostasis (tsarin matakan sukari na jini) da raguwar hankalin insulin sune mahimman abubuwan da ke da ala?a da rikicewar rayuwa. Rashin iyawar dagewa don sake shigar da glucose yadda ya kamata yana rushe tsarin sukari na jini kuma yana haifar da ha?akar cututtukan rayuwa kamar nau'in ciwon sukari na 2, kiba, da dyslipidemia. Bugu da ?ari, ha?arin kamuwa da cututtukan zuciya da jijiyoyin jini yana ?aruwa sosai. Tasiri kan lafiyar hanji da kuma microbiome Sucralose ana ?aukarsa "inert metabolically" saboda ba a tsotse shi ba amma an fitar da shi a cikin stool. Wannan yana sa ya zama ?asa da yuwuwar zama ma'auni don microbiome na gut. Koyaya, akwai shaidar cewa bayyanar sucralose na iya canza microbiota na gut ?in mu a kaikaice ta hanyar rashin kula da sukarin jini ko yuwuwar amsawar rigakafi. Nazarin dabba da yawa sun nuna cewa amfani da kayan zaki marasa gina jiki (NNS) na iya haifar da cututtuka na microbiome na hanji; Ya nuna karuwar yawan ?wayoyin cuta na ?wayoyin cuta da kuma rage yawan ?wayoyin cuta masu amfani. Koyaya, fitar da bayanan dabbobi ga mutane dole ne a yi su a hankali, saboda amfanin su ga lafiyar ?an adam da cuta na iya iyakancewa. Wani gwaji na asibiti da aka tsara don bincika sakamakon ?an gajeren lokaci (kwana 14 busasshen tsammanin) shan sucralose akan metabolism na glucose shima ya bincika sakamakon maimaitawar yau da kullun na NNS akan microbiota na gut. Binciken ya kammala cewa sucralose bai haifar da manyan canje-canje ba a cikin wadatar microbiota na gut ko ko'ina. Sabanin haka, wani gwajin gwajin da aka bazu na ?an gajeren lokaci ya nuna cewa ha?akar abinci tare da NNS na iya shafar yuwuwar aikin microbiome na ?an adam, tare da sucralose yana da tasiri mafi mahimmanci. Duk da haka, yana da mahimmanci a lura cewa duka gwaje-gwajen asibiti sun yi nazarin tasirin ?arin kariyar NNS na gajeren lokaci (ciki har da sucralose), kuma ana bu?atar lokuta masu tsawo don fahimtar lafiyar lafiyar lafiyar NNS akan microbiome na ?an adam. Sakamakon dogon lokaci na sucralose da sauran NNS akan microbiome gut ?an adam yanki ne na bincike mai gudana.

Abubuwan da ke tattare da jijiyoyin jini da tsarin ci Duk da cewa ana ?aukar sucralose maras kalori, yana ?arfafa masu kar?ar ?an?ano mai da?i, yana haifar da ?oyewar insulin a cikin pancreas, kuma yana fara ha?akar ?wayar cuta wanda ke kwaikwayon yanayin cin abinci. Idan babu glucose, ci gaba da samar da insulin yana sake daidaita ma'aunin mu na rayuwa da sinadarai na kwakwalwa. An yaudare masu ?an?anon mu don tunanin muna cin sukari na gaske. A cikin gwajin ?etare bazuwar, mahalarta mata masu kiba sun nuna ha?aka aiki a cikin sassan kwakwalwar da ke da ala?a da martanin abinci da sarrafa lada, wanda ke haifar da ha?akar adadin kuzari bayan cin sucralose. Wannan binciken yana ba da shaida mai gamsarwa cewa amfani da sucralose da sauran kayan zaki na wucin gadi yana da ala?a da ha?akar sha'awa da sha'awa, yawan cin abinci, da ha?akar kiba da kiba mai zuwa.