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Me yasa mannitol ke aiki don cututtukan urinary tract
2025-03-13
- Mannose (ko D-Mannose) sukari ne mai sau?i, amma ba kamar glucose ba, mannose ba ya cikin sau?i a cikin jiki bayan an sha shi, kuma kashi 90% na mannose yana fitar da shi kai tsaye ta cikin fitsari bayan kimanin minti 30 zuwa 60 bayan shan shi, don haka ba kamar glucose ba, mannose ba ya shafar sukari na jini, amma yana da hankali sosai a cikin fitsari. Mannose na iya tsoma baki tare da metabolism na glucose, hana shigar kitse, daidaita flora na hanji da shiga cikin tsarin rigakafi. Cikakken fahimtar tsarin aikin mannose a cikin maganin cututtuka masu dangantaka shine mabu?in don fadada aikace-aikacen asibiti.A cikin 'yan shekarun nan, an yi nazari da yawa akan mannose. A yau, za mu tattauna ko mannose yana da wani tasiri a kan maganin cututtukan urinary. Ciwon yoyon fitsari wata cuta ce da ke haifar da kamuwa da cutar bakteriya a kowace gabobin da ke kan titin fitsari, da suka hada da koda, ureter, mafitsara, urethra da sauransu. Saboda bambance-bambancen jiki tsakanin maza da mata, mata suna da damar kamuwa da cututtukan urinary mafi girma fiye da maza. Bincike ya nuna cewa mata na da kashi 50 cikin 100 na damar kamuwa da cutar yoyon fitsari a tsawon rayuwarsu, kuma tsakanin kashi uku da rabi na wadanda suka kamu da cutar za su kamu da cutar cikin shekara guda.Tun daga shekarun 1980, likitocin aikin likita suna amfani da mannose don magance cututtukan urinary fili. A cikin 'yan shekarun nan, tare da shaidun bincike da yawa da ke tabbatar da maganin warkewa da rigakafin cutar mannose, rawar da mannose ke takawa a cikin maganin cututtukan urinary ya jawo hankalin magunguna na yau da kullum.
Ta yaya mannose yake aiki?Lokacin da aka fitar da shi ta cikin koda, mafitsara, da urethra, mannose zai shigar da kwayoyin halitta masu wucewa da kwayoyin cuta da suke ?o?arin mannewa ga sel, yana sa kwayoyin ba za su iya mannewa ga mafitsara da ?wayoyin jijiyoyi ba, tare da toshe hanyar kamuwa da kwayoyin cuta, kuma kwayoyin da ba za su iya yin aiki da kyallen takarda ba za su bi fitsari daga jiki. Yawancin cututtukan urinary fili suna haifar da uropathogenic Escherichia coli (UPEC). UPEC tana ?aure da mannose a saman ?wayoyin epithelial na mafitsara ta hanyar furotin na FimH kuma fitsari baya wanke shi cikin sau?i. Sun canza mannose don samun mannoside (M4284). Dangantakarsa da furotin na FimH shine sau 100,000 sama da na mannose, amma baya mannewa saman mafitsara kuma ana iya fitar dashi tare da E. coli a cikin fitsari.A cikin nazarin kasa da kasa na 2016, marasa lafiya da suka dauki mannose na kwanaki 13 sun sami raguwa mai yawa a cikin alamun bayyanar cututtuka da kuma ci gaba mai mahimmanci a rayuwar su kamar yadda aka tantance ta tambayoyin tambayoyi. Don hana kamuwa da cututtukan urinary da ke faruwa akai-akai, masu bincike sun raba marasa lafiya zuwa kungiyoyi biyu, ?ungiyar masu shiga tsakani ta ci gaba da ?aukar mannose, ?ungiyar kulawa ba ta da wani abu. Sakamakon ?ungiyar mannose, kawai kashi 4.5 cikin ?ari na maimaitawa a cikin watanni shida, idan aka kwatanta da kashi 33.3 na ?ungiyar kulawa. Masu binciken sun kammala da cewa mannose na iya taimakawa wajen maganin cututtuka masu tsanani na yoyon fitsari kuma yana iya samun nasarar hana sake kamuwa da cutar.